Catalog No.
YRA21801
Expression system
E. coli
Species
Rattus norvegicus (Rat)
Protein length
Met1-Leu225
Predicted molecular weight
27 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O88583
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytokine-inducible SH2 protein 3, CIS-3, SSI-3, Suppressor of cytokine signaling 3, CIS3, STAT-induced STAT inhibitor 3, SSI3, SOCS3, SOCS-3,
Morphological and transcriptional insights into the role of histone phosphorylation-related genes in early development of the chicken duodenum., PMID:40506039
Identification of genes associated with liver ischemia-reperfusion injury after liver transplantation by WGCNA and PPI network analyses., PMID:40505700
CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor-driven proteome through PARP7 activity., PMID:40493189
Involvement of IL-6/JAK/STAT3/SOCS3, SIRT1, and Cytoglobin Signaling in Diacerein Protective Effect against Intestinal Injury Induced by Methotrexate., PMID:40488252
Enhancer profiling uncovers Jmjd1c as an essential suppressor in neuropathic pain by targeting Socs3., PMID:40485981
In-silico identification and experimental validation of shared genes and pathways to decipher the molecular links between COPD and MASLD., PMID:40482557
Modulation of microglial phagocytosis via the GAS6-MERTK pathway regulates pathological angiogenesis in the mouse oxygen-induced retinopathy model., PMID:40456730
Fufang zhenzhu tiaozhi capsule alleviates hypothalamic endoplasmic reticulum stress and leptin resistance through autophagy modulation in DIO rats., PMID:40436122
Preliminary Study of Differential circRNA Expression and Investigation of circRNA-miRNA-mRNA Competitive Endogenous Network in Rumen Acidosis of Holstein Cattle., PMID:40427349
Electroacupuncture stimulation inhibited astrogliosis and microglia polarisation to alleviate spinal cord injury via Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway., PMID:40421823
Phosphorylation of ITIM motifs drives the structural transition of indoleamine 2,3-dioxygenase 1 between enzymatic and non-enzymatic states., PMID:40371730
KDM6A Deficiency Induces Myeloid Bias and Promotes CMML-Like Disease Through JAK/STAT3 Activation by Repressing SOCS3., PMID:40365824
SIRT1-Mediated Regulation of STAT3/SOCS3 Inhibits Insulin Resistance in Trophoblast Cells and Improves Gestational Diabetes Mellitus., PMID:40346854
Acquired resistance to vemurafenib restrains thyroid cancer stem cell self-renewal by suppressing STAT3 activation., PMID:40345509
MiR-155 overexpression regulates Th1/Th2 balance by inhibiting BACH1 to activate Nrf-2/HO-1 signaling pathway in allergic rhinitis., PMID:40339975
Transcriptomic and epigenomic signatures of liver metabolism and insulin sensitivity in aging mice., PMID:40324540
Trans-spinal magnetic stimulation attenuates neuropathic pain caused by spinal cord injury., PMID:40313090
Socs3a is Dispensable for Zebrafish Hematopoiesis and is Required for Neuromast Formation., PMID:40302337
Long-term systemic androgen deprivation partially modulates neuroinflammation in male AppNL-G-F/NL-G-F mice., PMID:40289160
LncRNA transcriptome analysis of rainbow trout (Oncorhynchus mykiss) skin infected with IHNV reveals that lncRNA SARL/miR-205-z/SOCS3 axis negatively regulates antiviral immunity mechanisms., PMID:40287819
A Potential Link Between Early Onset Reactive Astrogliosis and Adult-Onset Dysfunction of Leptin Signaling in Polyubiquitin Gene Ubb Knockout Mice., PMID:40287809
Moderate exercise relieves heart failure-induced skeletal muscle atrophy through the inhibition of MAPK/SOCS3 signaling., PMID:40286786
[Clinical characteristics and cytokine gene expression in patients with post-COVID-19 syndrome]., PMID:40267303
Neutralization of IL-33 ameliorates septic myocardial injury through anti-inflammatory, anti-oxidative, and anti-apoptotic by regulating the NF-κB/STAT3/SOCS3 signaling pathway., PMID:40258576
Integrating network pharmacology and in vivo pharmacological validation to explore the gastroprotective mechanism of Sotetsuflavone against indomethacin-induced gastric ulcer in rats: Involvement of JAK2/STAT3 pathway., PMID:40258498
PTGS2 Silencing Inhibits Ferroptosis in Staphylococcus Aureus-induced Osteomyelitis By Blocking the IL-17A Signaling Pathway., PMID:40257651
Low-intensity exercise prevents cardiac inflammation through the NF-κB/TNFα pathway in insulin-resistant male rats., PMID:40244304
Kinsenoside attenuates ER stress and inhibits inflammatory responses through IL-10/STAT/SOCS3 pathway in chronic pain relief., PMID:40222401
Lipocalin-2 promotes NSCLC progression by activating the JAK2/STAT3 signaling pathway., PMID:40211270
Paeoniflorin alleviated STZ-induced diabetic retinopathy via regulation of the PDI/ADAM17/MerTK pathway., PMID:40209310
Modulation of Macrophages TLR4-Mediated Transcriptional Response by Lacticaseibacillus rhamnosus CRL1505 and Lactiplantibacillus plantarum CRL1506., PMID:40141330
Transcriptomic and Lipidomic Characteristics of Subcutaneous Fat Deposition in Small-Sized Meat Ducks., PMID:40137123
Treadmill Exercise Modulates the Leptin/LepR/GSK-3β Signalling Pathway to Improve Leptin Sensitivity and Alleviate Neuroinflammation in High-Fat Diet-Fed APP/PS1 Mice., PMID:40131695
Role of the suppressor of cytokine signaling-3 in the pathogenesis of Graves' orbitopathy., PMID:40104138
Lentinan alleviates angiotensin II-induced myocardial remodeling through LMP7-SOCS3 signaling., PMID:40101827
Unravelling the role of PRKCI and key-cancer related genes in breast cancer development and metastasis., PMID:40100546
ROS-dependent SOCS3 upregulation disrupts regulatory T cell stability during autoimmune disease development., PMID:40090133
Interleukin-10 resistance in type 2 diabetes is associated with defective STAT3 signaling in human blood leukocytes., PMID:40080435
Suppression of miR-218 promotes SOCS3 expression to alleviate cognitive impairment and white matter injury after chronic cerebral hypoperfusion., PMID:40080253
Deficiency of neuronal LGR4 increases energy expenditure and inhibits food intake via hypothalamic leptin signaling., PMID:40069508
Conditioned medium from cultured cementoblasts upregulates amelotin gene expression via the SOCS3 signaling pathway., PMID:40047181
Long non-coding RNA-MIR181A1HG acts as an oncogene and contributes to invasion and metastasis in gastric cancer., PMID:40044982
Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement., PMID:40038284
Novel anti-inflammatory compounds that alleviate experimental autoimmune encephalomyelitis., PMID:40023067
Association of Selected STAT Inhibitors with Prolactin-Induced Protein (PIP) in Breast Cancer., PMID:40003884
Filgotinib Improves Experimental Pulmonary Fibrosis by Modulating JAK1/STAT3/SOCS3/IL-17A Signalling., PMID:39995397
Wheat Germ Peptide Ameliorates Hyperglycemia and Hyperlipidemia in Diabetic Rats Through Modulation of Suppressor of Cytokine Signaling-3/Insulin Receptor Substrate-1/Protein Kinase B and Lipid Metabolism Pathways., PMID:39945086
Association Between Active DNA Demethylation and Liver Fibrosis in Individuals with Metabolic-Associated Steatotic Liver Disease (MASLD)., PMID:39941038
Farnesoid X Receptor Attenuates the Tumorigenicity of Liver Cancer Stem Cells by Inhibiting STAT3 Phosphorylation., PMID:39940889
TRIM21 Promotes Endothelial Cell Activation via Accelerating SOCS3 Ubiquitination Degradation in Atherosclerosis., PMID:39921798
For research use only. Not for human or drug use.
