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Anti-Phospho-Tau (pSer422) Antibody (CBTAU-22.1)

Catalog #:   RHC82423 Specific References (100) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA
Accession: P10636
Overview

Catalog No.

RHC82423

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

MAPTL, Paired helical filament-tau, MTBT1, Microtubule-associated protein tau, TAU, Neurofibrillary tangle protein, MAPT, PHF-tau

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P10636

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

CBTAU-22.1

Data Image
References

Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse., PMID:40403829

Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse., PMID:40403829

Overlapping presence of β-amyloid, tau, p-tau, and α-synuclein in skin nerve fibers in Alzheimer's disease., PMID:40042672

Overlapping presence of β-amyloid, tau, p-tau, and α-synuclein in skin nerve fibers in Alzheimer's disease., PMID:40042672

Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease., PMID:39930142

Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease., PMID:39930142

Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer's Disease., PMID:39559872

Phase 1 Studies of the Anti-Tau Monoclonal Antibody JNJ-63733657 in Healthy Participants and Participants with Alzheimer's Disease., PMID:39559872

CSF complement proteins are elevated in prodromal to moderate Alzheimer's disease patients and are not altered by the anti-tau antibody semorinemab., PMID:39369294

CSF complement proteins are elevated in prodromal to moderate Alzheimer's disease patients and are not altered by the anti-tau antibody semorinemab., PMID:39369294

Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy., PMID:39368113

Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy., PMID:39368113

The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer's disease., PMID:39284839

The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer's disease., PMID:39284839

iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death., PMID:39032719

iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death., PMID:39032719

Biomarkers as Endpoints in Clinical Trials for Alzheimer's Disease., PMID:38669547

Biomarkers as Endpoints in Clinical Trials for Alzheimer's Disease., PMID:38669547

Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies., PMID:38585836

Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies., PMID:38585836

Anti-GluA3 autoantibodies define a new sub-population of frontotemporal lobar degeneration patients with distinct neuropathological features., PMID:38485064

Anti-GluA3 autoantibodies define a new sub-population of frontotemporal lobar degeneration patients with distinct neuropathological features., PMID:38485064

Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation., PMID:38408247

Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation., PMID:38408247

Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change., PMID:38353753

Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change., PMID:38353753

Distinct tau and alpha-synuclein molecular signatures in Alzheimer's disease with and without Lewy bodies and Parkinson's disease with dementia., PMID:38198008

Distinct tau and alpha-synuclein molecular signatures in Alzheimer's disease with and without Lewy bodies and Parkinson's disease with dementia., PMID:38198008

Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates., PMID:37408256

Organotypic Hippocampal Slice Cultures from Adult Tauopathy Mice and Theragnostic Evaluation of Nanomaterial Phospho-TAU Antibody-Conjugates., PMID:37408256

Yeast biopanning against site-specific phosphorylations in tau., PMID:37294629

Yeast biopanning against site-specific phosphorylations in tau., PMID:37294629

The Effects of a Blood-Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy., PMID:37111315

The Effects of a Blood-Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy., PMID:37111315

Aquaporin 4 is differentially increased and dislocated in association with tau and amyloid-beta., PMID:36934970

Aquaporin 4 is differentially increased and dislocated in association with tau and amyloid-beta., PMID:36934970

Altered localization of nucleoporin 98 in primary tauopathies., PMID:36601621

Altered localization of nucleoporin 98 in primary tauopathies., PMID:36601621

Herpes simplex virus alters Alzheimer's disease biomarkers - A hypothesis paper., PMID:36396609

Herpes simplex virus alters Alzheimer's disease biomarkers - A hypothesis paper., PMID:36396609

Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation., PMID:36350059

Site-Specific Phospho-Tau Aggregation-Based Biomarker Discovery for AD Diagnosis and Differentiation., PMID:36350059

Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy., PMID:36109185

Evaluation of Tau Radiotracers in Chronic Traumatic Encephalopathy., PMID:36109185

A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model., PMID:35798978

A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model., PMID:35798978

Primary Sjögren's Syndrome Presenting with Rapidly Progressive Dementia: A Case Report., PMID:35761497

Primary Sjögren's Syndrome Presenting with Rapidly Progressive Dementia: A Case Report., PMID:35761497

Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome., PMID:35676735

Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome., PMID:35676735

Pyramidal cell axon initial segment in Alzheimer´s disease., PMID:35610289

Pyramidal cell axon initial segment in Alzheimer´s disease., PMID:35610289

Alzheimer disease neuropathology in a patient previously treated with aducanumab., PMID:35581440

Alzheimer disease neuropathology in a patient previously treated with aducanumab., PMID:35581440

Aducanumab and Its Effects on Tau Pathology: Is This the Turning Point of Amyloid Hypothesis?, PMID:35216126

Aducanumab and Its Effects on Tau Pathology: Is This the Turning Point of Amyloid Hypothesis?, PMID:35216126

Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation., PMID:34933123

Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation., PMID:34933123

Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction., PMID:34693486

Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction., PMID:34693486

From Cerebrospinal Fluid Neurochemistry to Clinical Diagnosis of Alzheimer's Disease in the Era of Anti-Amyloid Treatments. Report of Four Patients., PMID:34680493

From Cerebrospinal Fluid Neurochemistry to Clinical Diagnosis of Alzheimer's Disease in the Era of Anti-Amyloid Treatments. Report of Four Patients., PMID:34680493

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in the Era of Disease-Modifying Treatments., PMID:34679323

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in the Era of Disease-Modifying Treatments., PMID:34679323

Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns., PMID:34635189

Anatomic survey of seeding in Alzheimer's disease brains reveals unexpected patterns., PMID:34635189

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia., PMID:34471104

Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia., PMID:34471104

Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies., PMID:34363663

Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies., PMID:34363663

Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease., PMID:34129723

Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease., PMID:34129723

Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds., PMID:33653397

Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds., PMID:33653397

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model., PMID:33452414

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model., PMID:33452414

Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease., PMID:33380492

Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer's disease., PMID:33380492

A novel approach to correlate the salivary exosomes and their protein cargo in the progression of cognitive impairment into Alzheimer's disease., PMID:33075328

A novel approach to correlate the salivary exosomes and their protein cargo in the progression of cognitive impairment into Alzheimer's disease., PMID:33075328

Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody., PMID:32894244

Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody., PMID:32894244

Basophilic invasion in the neurohypophysis is increased in patients with Alzheimer's disease., PMID:32589126

Basophilic invasion in the neurohypophysis is increased in patients with Alzheimer's disease., PMID:32589126

The methanolic extract of Cinnamomum zeylanicum bark improves formaldehyde-induced neurotoxicity through reduction of phospho-tau (Thr231), inflammation, and apoptosis., PMID:32536837

The methanolic extract of Cinnamomum zeylanicum bark improves formaldehyde-induced neurotoxicity through reduction of phospho-tau (Thr231), inflammation, and apoptosis., PMID:32536837

Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases., PMID:32106300

Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases., PMID:32106300

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy., PMID:31907603

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy., PMID:31907603

Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice., PMID:31839610

Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice., PMID:31839610

Glial and neuroaxonal biomarkers in a multiple sclerosis (MS) cohort., PMID:31802051

Glial and neuroaxonal biomarkers in a multiple sclerosis (MS) cohort., PMID:31802051

Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model., PMID:31734318

Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model., PMID:31734318

Anti-Phospho-Tau Gene Therapy for Chronic Traumatic Encephalopathy., PMID:31608704

Anti-Phospho-Tau Gene Therapy for Chronic Traumatic Encephalopathy., PMID:31608704

Cross species application of quantitative neuropathology assays developed for clinical Alzheimer's disease samples., PMID:31528297

Cross species application of quantitative neuropathology assays developed for clinical Alzheimer's disease samples., PMID:31528297

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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Anti-Phospho-Tau (pSer422) Antibody (CBTAU-22.1) [RHC82423]
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