Catalog No.
YHD34301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val287-Tyr475
Predicted molecular weight
23.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P19474
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin-protein ligase TRIM21, 2.3.2.27, 52 kDa Ro protein, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, RING finger protein 81, RING-type E3 ubiquitin transferase TRIM21, Ro(SS-A), Sjoegren syndrome type A antigen, SS-A, Tripartite motif-containing protein 21, TRIM21, RNF81, RO52, SSA1
Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain., PMID:40514378
Macrophage TRIM21 knockout inhibits septic acute lung injury by downregulating autophagy regulator protein ubiquitination., PMID:40509575
TRIM21-based degradation strategy for multimeric proteins., PMID:40487632
The E3 ligase TRIM21 promotes progression of pancreatic ductal adenocarcinoma by down-regulating TAp63α and derepressing IL20RB., PMID:40460193
CD38 inhibits ferroptosis to promote radiotherapy resistance in nasopharyngeal carcinoma by competitively binding to TRIM21 to stabilize SLC7A11 protein., PMID:40449774
Identification of TRIM21 and TRIM14 as Antiviral Factors Against Langat and Zika Viruses., PMID:40431659
Anti-Ro52/TRIM21 autoantibodies predict Sjögren's syndrome in patients with primary biliary cholangitis., PMID:40418171
Mechanistic considerations linking SARS-CoV-2 infection, inflammation, and the loss of immune tolerance., PMID:40412200
ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia-derived mesenchymal stem cells., PMID:40401147
AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K/Akt/mTOR pathway., PMID:40394639
Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway., PMID:40379610
Ubiquitin-conjugating enzyme UBE2N modulates proteostasis in immunoproteasome-positive acute myeloid leukemia., PMID:40371639
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression., PMID:40370540
TRIM21 knockdown alleviates hemorrhage induced hepatic ischemia reperfusion injury by suppressing ferroptosis-induced NETs., PMID:40369118
Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosis., PMID:40344718
Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD-MASH Transition by Disrupting Carnitine Biosynthesis., PMID:40344326
Aryl Hydrocarbon Receptor (AHR) Suppresses Arsenic (As3+)-Induced Malignant Transformation by Antagonizing TOX Expression., PMID:40303305
Ubiquitin-dependent proteasomal degradation of small hepatitis B virus surface antigen mediated by TRIM21 and antagonized by OTUD4., PMID:40277358
The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation-Ubiquitylation Crosstalk of HMGA2., PMID:40265981
Therapy-induced senescent glioblastoma cells sustain a procancer immune microenvironment by activating DDX58-mediated STAT1 signaling., PMID:40259469
Chemically Induced Nuclear Pore Complex Protein Degradation via TRIM21., PMID:40247740
Expanding the Scope of Molecular Glues: TRIM21 as a Multimeric Protein Degrader., PMID:40242155
Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness., PMID:40223186
ENC1 Promotes the Malignant Progression and Metastasis by Suppressing TRIM21 Mediated Vimentin Degradation in Wilms Tumor., PMID:40222040
Tumor-Derived CD109 Orchestrates Reprogramming of Tumor-Associated Macrophages to Dampen Immune Response., PMID:40220905
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation., PMID:40215968
TRIM21-NUP98 Interface Accommodates Structurally Diverse Molecular Glue Degraders., PMID:40204658
TRIM21-mediated METTL3 degradation promotes PDAC ferroptosis and enhances the efficacy of Anti-PD-1 immunotherapy., PMID:40175350
TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus., PMID:40165656
Friend or foe of tripartite motif-containing protein 21 in cardiovascular disease: A review., PMID:40164260
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules., PMID:40141410
TRIM21-driven K63-linked ubiquitination of RBM38c, as a novel interactor of BECN1, contributes to DNA damage-induced autophagy., PMID:40133668
Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma., PMID:40132584
Perfluorooctane sulfonate induced ferritinophagy via detyrosinated alpha tubulin-TRIM21-HERC2-regulated NCOA4 degradation in hepatocytes., PMID:40120846
POT, an optogenetics-based endogenous protein degradation system., PMID:40102608
TRIM21 modulates stability of pro-survival non-coding RNA vtRNA1-1 in human hepatocellular carcinoma cells., PMID:40096176
RBMS3-loss impedes TRIM21-induced ubiquitination of ANGPT2 in an RNA-independent manner and drives sorafenib resistance in hepatocellular carcinoma., PMID:40069332
Neutrophil-derived heparin-binding protein increases endothelial permeability in acute lung injury by promoting TRIM21 and the ubiquitination of P65., PMID:40045003
The antibody repertoire of autoimmune sensory neuronopathies targets pathways of the innate and adaptive immune system. An autoantigenomic approach., PMID:40026393
TRIM21 interacts with IκBα and negatively regulates NF-κB activation in Corynebacterium pseudotuberculosis-infected macrophages., PMID:40020570
Long noncoding RNA USP30-AS1 promotes influenza A virus replication by enhancing PHB1 function., PMID:40020267
TRIM21 knockout alleviates renal fibrosis by promoting autophagic degradation of mature TGF-β1., PMID:39983846
IFNβ drives ferroptosis through elevating TRIM22 and promotes the cytotoxicity of RSL3., PMID:39975542
LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure., PMID:39955622
TRIM21 Promotes Endothelial Cell Activation via Accelerating SOCS3 Ubiquitination Degradation in Atherosclerosis., PMID:39921798
Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy., PMID:39911741
Targeting the TRIM21-PD-1 axis potentiates immune checkpoint blockade and CAR-T cell therapy., PMID:39905727
Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation-Mediated FGFR4 Activation., PMID:39903812
Phospho-TRIM21 orchestrates RPA2 ubiquitination switch to promote homologous recombination and tumor radio/chemo-resistance., PMID:39900724
TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression., PMID:39890802
For research use only. Not for human or drug use.
