Enhanced Antitumor Immunity of a Globo H-Based Vaccine Enabled by the Combination Adjuvants of 3D-MPL and QS-21., PMID:39679641
Phase I-II study of OBI-888, a humanized monoclonal IgG1 antibody against the tumor-associated carbohydrate antigen Globo H, in patients with advanced solid tumors., PMID:39311947
A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies., PMID:38912881
Investigation of the impact of Globo-H expression on the progression of gastric cancer., PMID:37560002
Mechanism of Antigen Presentation and Specificity of Antibody Cross-Reactivity Elicited by an Oligosaccharide-Conjugate Cancer Vaccine., PMID:37089019
First-in-Human Study of OBI-999, a Globo H-Targeting Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors., PMID:36701651
Outcomes Following GD2-Directed Postconsolidation Therapy for Neuroblastoma After Cessation of Random Assignment on ANBL0032: A Report From the Children's Oncology Group., PMID:35839426
Long-term outcomes of patients with recurrent ovarian cancer treated with a polyvalent vaccine with bevacizumab combination., PMID:35779095
The clinical relevance of humoral immune responses to Globo H-KLH vaccine adagloxad simolenin (OBI-822)/OBI-821 and expression of Globo H in metastatic breast cancer., PMID:35732348
Generation of glycan-specific nanobodies., PMID:35705094
Targeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives., PMID:35158915
Synthesis of Azido-Globo H Analogs for Immunogenicity Evaluation., PMID:35106375
Improved Outcome in Children With Newly Diagnosed High-Risk Neuroblastoma Treated With Chemoimmunotherapy: Updated Results of a Phase II Study Using hu14.18K322A., PMID:34871104
The role of Globo H and SSEA-4 in the development and progression of cancer, and their potential as therapeutic targets., PMID:34734786
Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma., PMID:34558839
Combined Effect of Anti-SSEA4 and Anti-Globo H Antibodies on Breast Cancer Cells., PMID:34369155
Synthesis and immunological evaluation of N-acyl modified Globo H derivatives as anticancer vaccine candidates., PMID:34355188
Chemical synthesis and immunological evaluation of entirely carbohydrate conjugate Globo H-PS A1., PMID:34123241
Preclinical Studies of OBI-999: A Novel Globo H-Targeting Antibody-Drug Conjugate., PMID:33722855
Glycan chip based on structure-switchable DNA linker for on-chip biosynthesis of cancer-associated complex glycans., PMID:33654088
Targeting glycosphingolipids for cancer immunotherapy., PMID:32860713
A phase II randomized, double-blind trial of a polyvalent Vaccine-KLH conjugate (NSC 748933 IND# 14384) + OPT-821 versus OPT-821 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer who are in second or third complete remission: An NRG Oncology/GOG study., PMID:31653510
Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer., PMID:30808745
Naturally occurring anti-glycan antibodies binding to Globo H-expressing cells identify ovarian cancer patients., PMID:28187738
Glycosphingolipid dynamics in human embryonic stem cell and cancer: their characterization and biomedical implications., PMID:27549315
Alterations of Glycosphingolipids in Embryonic Stem Cell Differentiation and Development of Glycan-Targeting Cancer Immunotherapy., PMID:27507584
A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission., PMID:27110823
A Fully Synthetic Self-Adjuvanting Globo H-Based Vaccine Elicited Strong T Cell-Mediated Antitumor Immunity., PMID:26918109
Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells., PMID:26677875
Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1., PMID:26405690
Development of Globo-H cancer vaccine., PMID:25665650
Synthesis and characterization of a novel chemically designed (Globo)3-DTPA-KLH antigen., PMID:25565775
Analysis of breast cancer-associated glycosphingolipids using electrospray ionization-linear ion trap quadrupole mass spectrometry., PMID:25498019
Immunogenicity study of Globo H analogues with modification at the reducing or nonreducing end of the tumor antigen., PMID:25371992
Affinity of monoclonal antibodies for Globo-series glycans., PMID:25163606
Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers., PMID:24550271
Downregulation of microRNA-15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2-induced Globo H expression., PMID:24122375
Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes., PMID:23908400
Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer., PMID:23355685
Recent advances in developing synthetic carbohydrate-based vaccines for cancer immunotherapies., PMID:22416779
Immunization with N-propionyl polysialic acid-KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci., PMID:21811785
Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation., PMID:21149694
The known immunologically active components of Astragalus account for only a small proportion of the immunological adjuvant activity when combined with conjugate vaccines., PMID:21128203
From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine., PMID:19518111
New development of glycan arrays., PMID:19462030
For research use only. Not for human or drug use.
