Catalog No.
YWJ69501
Expression system
E. coli
Species
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Protein length
Met1-Asp235
Predicted molecular weight
27.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
XP_024645499.1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FIL1Z, IL37, Interleukin-1-related protein, IL-23, IL1F7, IL-37, IL1RP1, FIL1 zeta, IL-1X, Interleukin-23, IL-1F7, IL-1RP1, Interleukin-1 family member 7, Interleukin-37, Interleukin-1 homolog 4, Interleukin-1 zeta, IL-1H, IL-1H4, IL-1 zeta, IL1H4,
Interleukin-37 modulates microglial phenotype and inhibits inflammatory response via the MyD88/NF-κB pathway in lipopolysaccharide-induced neuroinflammation., PMID:40439750
The Potential Contribution of the IL-37/IL-18/IL-18BP/IL-18R Axis in the Pathogenesis of Sjögren's Syndrome., PMID:40430016
Neuroinflammation and Amyotrophic Lateral Sclerosis: Recent Advances in Anti-Inflammatory Cytokines as Therapeutic Strategies., PMID:40332510
IL-37 Protects Against Ventilator-Induced Lung Injury by Inhibiting NLRP3 Activation., PMID:40325829
Interleukin-37 reduces lipopolysaccharide induced matrix metalloproteinase-9 in gingival epithelial cells., PMID:40281482
Human regulatory B cells suppress autoimmune disease primarily via interleukin-37., PMID:40250016
The stress and the alarmin-like cytokine interleukin-37 mediated extracellular and intracellular signal pathways., PMID:40209639
The distinct roles of IL-37 and IL-38 in non-small cell lung carcinoma and their clinical implications., PMID:40191189
FCGR1A(CD64) expression on monocyte subsets and FIL1Z(IL-37) serum level as biomarkers of rheumatoid arthritis activity: A case controlled study and in silico analysis., PMID:40088754
AAV9-delivery of interleukin-37b gene prevents recurrent herpetic stromal keratitis via the SIGIRR pathway in mice., PMID:40043913
[Research advance on the role of interleukin-18, interleukin-37b and basophils in sepsis]., PMID:39968592
Interleukin-37 attenuates aortic valve lesions by inhibiting N6-methyladenosine-mediated interleukin-1 receptor-associated kinase M degradation., PMID:39913240
Epigenetic mechanisms underlying endometrial cancer outcomes: race-specific patterns of DNA methylation associated with molecular subtypes and survival., PMID:39873457
Computational modeling of the anti-inflammatory complexes of IL37., PMID:39854883
A review of cutting-edge biomarkers for diagnosing coronary artery disease., PMID:39854741
IL-37 attenuated HPV induced inflammation of oral epithelial cells via inhibiting PI3K/AKT/mTOR., PMID:39736667
Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway., PMID:39714100
Prognostic Value of Serum Interleukin-37 in Patients with Acute Respiratory Distress Syndrome., PMID:39698874
IL-37 Isoform A Prevents Collagen-Induced Arthritis in Mice by Modulating the Th17/Treg Balance via IL1R8 Receptors., PMID:39684587
Nasal secretions trace epithelial type 2 response to allergen-specific immunotherapy., PMID:39660695
Therapeutic Potential of IL-37 in Cervical Cancer: Suppression of Tumour Progression and Enhancement of CD47-Mediated Macrophage Phagocytosis., PMID:39620401
Potential and limitations of IL-37, a cytokine targeted for therapy of systemic lupus erythematosus: A Systematic Review., PMID:39566387
Potential pro-tumour cytokine in oral squamous cellular carcinoma: IL37., PMID:39500733
Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030
Recombinant expression, downstream optimization, and therapeutic evaluation of recombinant human interleukin-37 for cancer therapy., PMID:39424749
The role of selected cytokines from the interleukin-1 family in the peritoneal fluid of women with endometriosis., PMID:39411821
Expanding Role of Interleukin-1 Family Cytokines in Acute Ischemic Stroke., PMID:39408843
Pulsed electromagnetic fields inhibit IL-37 to alleviate CD8+ T cell dysfunction and suppress cervical cancer progression., PMID:39404933
The Protective Role of Interleukin-37 in Cardiovascular Diseases through Ferroptosis Modulation., PMID:39337246
Insights into the multifaceted role of interleukin-37 on human immune cell regulation., PMID:39307482
Interleukin(IL)-37 attenuates isoproterenol (ISO)-induced cardiac hypertrophy by suppressing JAK2/STAT3-signaling associated inflammation and oxidative stress., PMID:39293311
Interleukin-37 exacerbates liver inflammation and promotes IFN-γ production in NK cells., PMID:39260304
The role of IL-37 in gastrointestinal diseases., PMID:39206201
A Narrative Review of the IL-18 and IL-37 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets., PMID:39126010
The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies., PMID:38992217
IL-37 protects against house dust mite-induced airway inflammation and airway epithelial barrier dysfunction via inhibiting store-operated calcium entry., PMID:38941668
Epidermal growth factor receptor/mitogen-activated kinase inhibitor treatment induces a distinct inflammatory hair follicle response that includes collapse of immune privilege., PMID:38857906
Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters., PMID:38840067
IL-37 possesses both anti-inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection., PMID:38803038
IL-37 ameliorates myocardial fibrosis by regulating mtDNA-enriched vesicle release in diabetic cardiomyopathy mice., PMID:38790051
C5a peptidase (ScpA) activity towards human type II and type III interferons., PMID:38759527
Immune System Dysregulation in the Progression of Multiple Sclerosis: Molecular Insights and Therapeutic Implications., PMID:38692349
Neutrophil-derived nanovesicles deliver IL-37 to mitigate renal ischemia-reperfusion injury via endothelial cell targeting., PMID:38631490
Recombinant human IL-37 attenuates acute cardiac allograft rejection in mice., PMID:38583255
Targeting IL-13 with tralokinumab normalizes type 2 inflammation in atopic dermatitis both early and at 2 years., PMID:38563683
Clinical significance of IL-37 serum level and polymorphism in patients with endometrial cancer., PMID:38526176
Ectoine protects corneal epithelial survival and barrier from hyperosmotic stress by promoting anti-inflammatory cytokine IL-37., PMID:38490477
Role of Platelet/Lymphocyte, Neutrophil/Lymphocyte, and Interleukin-37/Interleukin-17 Ratios in the Occurrence and Treatment of Rheumatoid Arthritis., PMID:38477623
Serum Levels of Interleukins in Endometriosis Patients: A Systematic Review and Meta-analysis., PMID:38428575
IL-37d enhances COP1-mediated C/EBPβ degradation to suppress spontaneous neutrophil migration and tumor progression., PMID:38363681
For research use only. Not for human or drug use.
