Catalog No.
RHD31102
Species reactivity
Human, Rat
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Target
ATF4, CREB2, TXREB, Cyclic AMP-dependent transcription factor ATF-4, cAMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, Tax-responsive enhancer element-binding protein 67, TaxREB67
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P18848
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
N360A/24
Arsenic Trioxide Enhances the Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma by Inducing Immunogenic Cell Death via the ROS/ERS Pathway., PMID:40504080
Anti-TNFα and Anti-IL-1β Monoclonal Antibodies Preserve BV-2 Microglial Homeostasis Under Hypoxia by Mitigating Inflammatory Reactivity and ATF4/MAPK-Mediated Apoptosis., PMID:40338234
C/EBP Homologous Protein Expression in Retinal Ganglion Cells Induces Neurodegeneration in Mice., PMID:40076484
ATF4 promotes glutaminolysis and glycolysis in colorectal cancer by transcriptionally inducing SLC1A5., PMID:39696988
Inhibition of ER stress using tauroursodeoxycholic acid rescues obesity-evoked cardiac remodeling and contractile anomalies through regulation of ferroptosis., PMID:38906502
EMC10 modulates hepatic ER stress and steatosis in an isoform-specific manner., PMID:38599383
BMP2-ERK-ATF4 Axis-Based 6-methoxybenzofuran Compound I-9 Acts as Candidate Drug for Bone Formation and Anti-Osteoporosis., PMID:38542323
APOE and Alzheimer's disease: Pathologic clues from transgenic Drosophila melanogaster., PMID:38537387
Bone marrow plasma cells require P2RX4 to sense extracellular ATP., PMID:38355795
DWN12088, A Prolyl-tRNA Synthetase Inhibitor, Alleviates Hepatic Injury in Nonalcoholic Steatohepatitis., PMID:38173372
The chaperone protein GRP78 released from MPN cells increases the expression of lysyl oxidase in a human stromal cell line., PMID:37757654
Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells., PMID:37709749
Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system., PMID:37520825
Rebalancing liver-infiltrating CCR3+ and CD206+ monocytes improves diet-induced NAFLD., PMID:37421620
XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells., PMID:37329685
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells., PMID:36115171
The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress., PMID:35871648
Endoplasmic reticulum-stress and unfolded protein response-activation in immune-mediated necrotizing myopathy., PMID:35703068
NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria., PMID:35029280
Discontinuation of PTH therapy amplifies bone loss by increasing oxidative stress: An event ameliorated by sequential IL-17 neutralizing antibody therapy., PMID:34839260
Modulation of the Physical Properties of 3D Spheroids Derived from Human Scleral Stroma Fibroblasts (HSSFs) with Different Axial Lengths Obtained from Surgical Patients., PMID:34698138
Induction of IL-6Rα by ATF3 enhances IL-6 mediated sorafenib and regorafenib resistance in hepatocellular carcinoma., PMID:34687791
A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis., PMID:34350183
Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro., PMID:32728889
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification., PMID:32609329
Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis., PMID:32391876
Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress., PMID:31907991
NK cells induce hepatic ER stress to promote insulin resistance in obesity through osteopontin production., PMID:31829469
Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway., PMID:31523192
Elevated ATF4 Expression in Odontogenic Keratocysts Epithelia: Potential Involvement in Tissue Hypoxia and Stromal M2 Macrophage Infiltration., PMID:31424999
An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy., PMID:31086176
Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents., PMID:31040105
New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review., PMID:30134550
Host-parasite interaction associated with major mental illness., PMID:30127472
Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner., PMID:30036391
Untangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine., PMID:29940077
Nrf2 protects human lens epithelial cells against H2O2-induced oxidative and ER stress: The ATF4 may be involved., PMID:29421327
Regulation of gammaherpesvirus lytic replication by endoplasmic reticulum stress-induced transcription factors ATF4 and CHOP., PMID:29305424
Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease., PMID:29289645
Enhanced IgG1 production by overexpression of nuclear factor kappa B inhibitor zeta (NFKBIZ) in Chinese hamster ovary cells., PMID:29188404
TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy., PMID:28724746
Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic., PMID:28379093
Functional block of IL-17 cytokine promotes bone healing by augmenting FOXO1 and ATF4 activity in cortical bone defect model., PMID:28341898
ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure., PMID:28213613
Intermedin1-53 Protects Against Myocardial Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Inflammation Induced by Homocysteine in Apolipoprotein E-Deficient Mice., PMID:27052784
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis., PMID:27697610
Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency., PMID:27486236
Compression loading-induced stress responses in intervertebral disc cells encapsulated in 3D collagen constructs., PMID:27197886
Niclosamide induced cell apoptosis via upregulation of ATF3 and activation of PERK in Hepatocellular carcinoma cells., PMID:26917416
Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function., PMID:26887051
For research use only. Not for human or drug use.
