Catalog No.
YMC32101
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Phe42-Glu237
Predicted molecular weight
25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q3UP87
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neutrophil elastase, 3.4.21.37, Elastase-2, Leukocyte elastase, Elane, Ela2
ELANE enhances KEAP1 protein stability and reduces NRF2-mediated ferroptosis inhibition in metabolic dysfunction-associated fatty liver disease., PMID:40204709
Downregulation of tropomyosin 2 promotes the progression of lung adenocarcinoma by regulating neutrophil infiltration through neutrophil elastase., PMID:40199876
Tetrahedral DNA-Enhanced Interparticle Rolling Machine for High-Efficiency Human Neutrophil Elastase SERS Ratiometric Sensing in Serum and Tissue., PMID:40047041
Evaluation of Neutrophil Elastase Inhibitors as Potential Therapies for ELANE Associated Neutropenia., PMID:39867870
The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure., PMID:39788946
Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface., PMID:39777987
CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis., PMID:39707013
Neutrophil Elastase Targets Select Proteins on Human Blood-Monocyte-Derived Macrophage Cell Surfaces., PMID:39684750
Case report: A cyclic neutropenia patient with ELANE mutation accompanied by hemophagocytic lymphohistiocytosis., PMID:39676859
Enzymatic, structural, and biophysical characterization of a single-domain antibody (VHH) selectively and tightly inhibiting neutrophil elastase and exhibiting favorable developability properties., PMID:39604162
G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing truncated-neutrophil elastase aggregates., PMID:39560992
Neutrophil Elastase, Neuron-Specific Enolase, and S100B Protein as Potential Markers of Long-Term Complications Caused by COVID-19 in Patients with Type 2 Diabetes Mellitus (T2DM) and Advanced Stage of Diabetic Nephropathy (NfT2DM)-Observational Studies., PMID:39519343
Increased Lipocalin 2 detected by RNA sequencing regulates apoptosis and ferroptosis in COPD., PMID:39462322
Comparison of Gene-Editing Approaches for Severe Congenital Neutropenia-Causing Mutations in the ELANE Gene., PMID:39436283
Behçet's disease modifies the gingival inflammatory response., PMID:39295442
Genetic causes of primary immunodeficiency in the Jordanian population., PMID:39268404
Robustaflavone as a novel scaffold for inhibitors of native and auto-proteolysed human neutrophil elastase., PMID:39246138
De Novo Deep Intron ELANE Mutation Resulting in Severe Congenital Neutropenia., PMID:39172268
Exploration of novel human neutrophil elastase inhibitors from natural compounds: Virtual screening, in vitro, molecular dynamics simulation and in vivo study., PMID:39159715
ELANE is a promising prognostic biomarker that mediates pyroptosis in gastric cancer., PMID:39130462
Human Neutrophil Elastase: Characterization of Intra- vs. Extracellular Inhibition., PMID:39063160
[Sivelestat sodium inhibits neutrophil elastase to regulate intrahepatic biliary mucin 5AC expression]., PMID:38991960
Proteomics analysis of deep fascia in acute compartment syndrome., PMID:38950026
Absence of Neutropenia in Patients With Early Exon Nonsense Mutations in ELANE : Clinical Evidence to Support Gene Therapy Approaches for Severe Congenital Neutropenia., PMID:38934594
Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages., PMID:38673851
Matrix metalloproteinase-9 and neutrophil elastase from infiltrating neutrophils with neutrophil extracellular DNA traps in linear IgA bullous dermatosis: A case report., PMID:38650312
CRISPR-Cas9n-mediated ELANE promoter editing for gene therapy of severe congenital neutropenia., PMID:38556793
LCN2 and ELANE overexpression induces sepsis., PMID:38363924
Ferritin-mediated neutrophil extracellular traps formation and cytokine storm via macrophage scavenger receptor in sepsis-associated lung injury., PMID:38308264
ELANE rs17223045C/T and rs3761007G/A variants: Protective factors against COVID-19., PMID:38226800
Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics., PMID:38219859
Botulinum toxin type A ameliorates rat dorsal root ganglia neuron pyroptosis in postherpetic neuralgia by upregulating cathelicidin antimicrobial peptide to inhibit neutrophil elastase., PMID:38065687
Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin., PMID:38042488
Screening for ELANE, HAX1 and GFI1 gene mutations in children with neutropenia and clinical characterization of two novel mutations in ELANE gene., PMID:37993852
Congenital neutropenia: From lab bench to clinic bedside and back., PMID:37989463
The promise of novel treatments for severe chronic neutropenia., PMID:37978893
Differential transcriptional control of hematopoiesis in congenital and cyclic neutropenia patients harboring ELANE mutations., PMID:37855057
Association of High Plasma Levels of Serpin E1, IGFBP2, and CCL5 With Refractory Epilepsy in Children by Cytokine Profiling., PMID:37731223
Neutrophil elastase as a potential biomarker related to the prognosis of gastric cancer and immune cell infiltration in the tumor immune microenvironment., PMID:37596368
Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice., PMID:37589142
Lack of eosinophil extracellular trap formation due to failure of plasma membrane breakdown in the absence of elastase., PMID:37428870
Neutrophil-activating Peptide 2 as a Novel Modulator of Fibrin Clot Properties in Patients with Atrial Fibrillation., PMID:37294500
Salivary and serum levels of neutrophil proteases in periodontitis and rheumatoid arthritis., PMID:36965040
Proteomic analysis of sialoliths from calcified, lipid and mixed groups as a source of potential biomarkers of deposit formation in the salivary glands., PMID:36949424
[Neutrophil elastase gene mutation-induced cyclic neutropenia: a case report]., PMID:36740410
A high prevalence of neutrophil-specific antibodies in ELANE-mutated severe congenital neutropenia., PMID:36734404
Severe congenital neutropenia caused by ELANE gene mutation: A case report and literature review., PMID:36343040
ELANE Promotes M2 Macrophage Polarization by Down-Regulating PTEN and Participates in the Lung Cancer Progression., PMID:36102787
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors., PMID:36070343
Neutrophil autophagy and NETosis in COVID-19: perspectives., PMID:35951555
For research use only. Not for human or drug use.
