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Research Grade Abrilumab (DHC98804)

Host species:Human
Isotype:IgG2-kappa
Applications:Research Grade Biosimilar
Expression system:Mammalian Cells
Overview

Catalog No.

DHC98804

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG2-kappa

Clonality

Monoclonal

Target

ITGA4, CD49d, CD49 antigen-like family member D, CD49D, VLA-4 subunit alpha, Integrin alpha-IV, Integrin alpha-4, Gut homing receptor beta subunit, Integrin beta-7, ITGB7

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P13612 & P26010

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

AMG 181, MEDI-7183, CAS: 1342290-43-0

Clone ID

Abrilumab

Data Image
  • SDS-PAGE
    SDS PAGE for Abrilumab
References

Emerging Treatment Options in Inflammatory Bowel Disease: Janus Kinases, Stem Cells, and More, PMID: 32570252

Anti-integrin therapy for inflammatory bowel disease, PMID: 29740202

Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis, PMID: 30472236

Efficacy and safety of abrilumab, an α4β7 integrin inhibitor, in Japanese patients with moderate-to-severe ulcerative colitis: a phase II study, PMID: 30739435

Emerging Therapies for Inflammatory Bowel Disease, PMID: 30374806

Interfering with leukocyte trafficking in Crohn's disease, PMID: 31327399

Gut-Selective Integrin-Targeted Therapies for Inflammatory Bowel Disease, PMID: 29767705

Anti-integrin drugs in clinical trials for inflammatory bowel disease (IBD): Insights into promising agents, PMID: 34449288

Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7 monoclonal antibody, for treating inflammatory bowel diseases, PMID: 24803302

Pharmacology of AMG 181, a human anti-α4 β7 antibody that specifically alters trafficking of gut-homing T cells, PMID: 23425116

Datasheet

Document Download

Research Grade Abrilumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Research Grade Abrilumab [DHC98804]
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