Catalog No.
DHG17602
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG4-kappa
Clonality
Monoclonal
Target
Leukocyte surface antigen CD47, CD47, Antigenic surface determinant protein OA3, IAP, Integrin-associated protein, Protein MER6, MER6
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q08722
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
CD47, SRF-231, SRF231, CAS: 2249722-58-3
Clone ID
Urabrelimab
Fluorescent and mass spectrometric evaluation of the phagocytic internalization of a CD47-peptide modified drug-nanocarrier. PMID: 31093697
CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models. PMID: 26093091
Enhanced biocompatibility of CD47-functionalized vascular stents. PMID: 26914699
RRx-001, a first-in-class small molecule inhibitor of MYC and a downregulator of CD47, is an "erythrophagoimmunotherapeutic". PMID: 33457091
CD47 protein expression in acute myeloid leukemia: A tissue microarray-based analysis. PMID: 25943033
Quantitative high-throughput screening assays for the discovery and development of SIRPalpha-CD47 interaction inhibitors. PMID: 31276567
CD47 functions as a molecular switch for erythrocyte phagocytosis. PMID: 22427202
Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. PMID: 30898840
CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer. PMID: 26077800
CD47-independent effects mediated by the TSP-derived 4N1K peptide. PMID: 24848268
CD47 is a Potential Target for the Treatment of Laryngeal Squamous Cell Carcinoma. PMID: 27855370
Anti-CD47 monoclonal antibody therapy reduces ischemia-reperfusion injury of renal allografts in a porcine model of donation after cardiac death. PMID: 29087049
Deciphering the complex role of thrombospondin-1 in glioblastoma development. PMID: 30850588
CD47 knockout mice exhibit improved recovery from spinal cord injury. PMID: 21168495
Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-beta-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression. PMID: 29463646
Nanoparticle enhanced MRI can monitor macrophage response to CD47 mAb immunotherapy in osteosarcoma. PMID: 30674867
Assessing and mitigating the interference of ALX148, a novel CD47 blocking agent, in pretransfusion compatibility testing. PMID: 32820530
Signaling Regulatory Protein (SIRP)alpha-CD47 Blockade Joins the Ranks of Immune Checkpoint Inhibition. PMID: 30811295
Inducing Tumor Suppressive Microenvironments through Genome Edited CD47(-/-) Syngeneic Cell Vaccination. PMID: 31882679
CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation. PMID: 26311851
The CD47 "don't eat me signal" is highly expressed in human ovarian cancer. PMID: 27569584
CD47 regulates renal tubular epithelial cell self-renewal and proliferation following renal ischemia reperfusion. PMID: 27259369
miR-128 Regulates Tumor Cell CD47 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer. PMID: 32536914
Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies. PMID: 28234345
Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPalpha-CD47 axis. PMID: 31089204
For research use only. Not for human or drug use.
