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Glembatumumab vedotin (ADC)

Catalog #:   DHG93199 Specific References (33) DATASHEET
Applications: Research Grade Biosimilar
Overview

Catalog No.

DHG93199

Description

Glembatumumab vedotin is an ADC consisting of a GPNMB-directed antibody and Monomethyl auristatin E (MMAE) used for the study of breast cancer and melanoma.

Species reactivity

Human

Clonality

Monoclonal

Target

GPNMB

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SEC.

Purification

Purified by Ion Exchange Chromatography.

Applications

Research Grade Biosimilar

Form

Liquid

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CR011-vcMMAE, CDX-011

Clone ID

Glembatumumab vedotin

Data Image
References

ImmunoPET Imaging Identifies the Optimal Timepoint for Combination Therapy in Xenograft Models of Triple-Negative Breast Cancer., PMID:36900378

From seaside to bedside: Current evidence and future perspectives in the treatment of breast cancer using marine compounds., PMID:36160422

Actively Targeted Nanomedicines in Breast Cancer: From Pre-Clinal Investigation to Clinic., PMID:35267507

HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin., PMID:35110681

Efficacy and Safety of Glembatumumab Vedotin in Patients With Advanced or Metastatic Squamous Cell Carcinoma of the Lung (PrECOG 0504)., PMID:34590018

Glembatumumab vedotin for patients with metastatic, gpNMB overexpressing, triple-negative breast cancer ("METRIC"): a randomized multicenter study., PMID:34016993

A Phase II Study of Glembatumumab Vedotin for Metastatic Uveal Melanoma., PMID:32823698

Phase II trial of the glycoprotein non-metastatic B-targeted antibody-drug conjugate, glembatumumab vedotin (CDX-011), in recurrent osteosarcoma AOST1521: A report from the Children's Oncology Group., PMID:31586757

Immunotherapy for Uveal Melanoma - Current Knowledge and Perspectives., PMID:31272342

A phase 2 study of glembatumumab vedotin, an antibody-drug conjugate targeting glycoprotein NMB, in patients with advanced melanoma., PMID:30690710

Antibody-drug conjugates in triple negative breast cancer., PMID:30175620

Immunoconjugates for Osteosarcoma Therapy: Preclinical Experiences and Future Perspectives., PMID:29439419

Antibodies to watch in 2018., PMID:29300693

Preclinical PET imaging of glycoprotein non-metastatic melanoma B in triple negative breast cancer: feasibility of an antibody-based companion diagnostic agent., PMID:29262642

Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer., PMID:28546082

Antibodies to watch in 2017., PMID:27960628

MAPK Pathway Inhibitors Sensitize BRAF-Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB., PMID:27515299

Emerging targeted therapies for melanoma., PMID:27148822

Targeting Glycoprotein NMB With Antibody-Drug Conjugate, Glembatumumab Vedotin, for the Treatment of Osteosarcoma., PMID:26305408

EMERGE: A Randomized Phase II Study of the Antibody-Drug Conjugate Glembatumumab Vedotin in Advanced Glycoprotein NMB-Expressing Breast Cancer., PMID:25847941

Antibody-drug conjugate for advanced melanoma?, PMID:25602109

Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with locally advanced or metastatic breast cancer., PMID:25267761

Phase I/II study of the antibody-drug conjugate glembatumumab vedotin in patients with advanced melanoma., PMID:25267741

Initial testing (stage 1) of glembatumumab vedotin (CDX-011) by the pediatric preclinical testing program., PMID:24912408

New developments in metastatic breast cancer: integrating recent data into clinical practice., PMID:24892840

Novel data in metastatic breast cancer., PMID:24637556

Management of metastatic breast cancer with second-generation antibody-drug conjugates: focus on glembatumumab vedotin (CDX-011, CR011-vcMMAE)., PMID:24496926

Glycoprotein non-metastatic b (GPNMB): A metastatic mediator and emerging therapeutic target in cancer., PMID:23874106

The use of an antibody drug conjugate, glembatumumab vedotin (CDX-011), for the treatment of breast cancer., PMID:22229970

Gpnmb/osteoactivin, an attractive target in cancer immunotherapy., PMID:22017590

GPNMB expression in uveal melanoma: a potential for targeted therapy., PMID:20375921

Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer., PMID:20373269

Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer., PMID:20215530

Datasheet

Document Download

Glembatumumab vedotin (ADC).pdf

 

$ 2540
Product specifications
1 mg 2540 5 mg 6360

Contact Information

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Distributor list

For research use only. Not for human or drug use.

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Glembatumumab vedotin (ADC) [DHG93199]
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