Anti-Mouse JAM3 Polyclonal Antibody

Catalog No.

PMK97701

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse JAM3 (Glu30-Asp239).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)]

Purification

Purified by antigen affinity column.

Accession

Q9D8B7

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Threonine attenuates lipopolysaccharide-induced intestinal inflammatory responses in rabbits., PMID:39549129

Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML., PMID:38954834

Junctional adhesion molecule 3 is a potential therapeutic target for small cell lung carcinoma., PMID:36990421

Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma., PMID:36768928

Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling., PMID:36461092

Analyzing normal and disrupted leukemic stem cell adhesion to bone marrow stromal cells by single-molecule tracking nanoscopy., PMID:34435622

Flow Cytometry Analysis of Mouse Hematopoietic Stem and Multipotent Progenitor Cells., PMID:34057715

Immunoglobulin superfamily receptor Junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes., PMID:33933422

Dietary addition of garlic straw improved the intestinal barrier in rabbits1., PMID:31433053

CIRP Induces Neutrophil Reverse Transendothelial Migration in Sepsis., PMID:30148763

Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4+ aged neutrophils., PMID:30088666

Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice., PMID:29753567

JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling., PMID:29584620

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis., PMID:28617811

JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress., PMID:28203682

Anti-JAM-C therapy eliminates tumor engraftment in a xenograft model of mantle cell lymphoma., PMID:27256571

Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury., PMID:26841848

Loss of JAM-C leads to impaired esophageal innervations and megaesophagus in mice., PMID:26123848

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo., PMID:26047922

Blocking junctional adhesion molecule C enhances dendritic cell migration and boosts the immune responses against Leishmania major., PMID:25474593

JAM-C promotes lymphangiogenesis and nodal metastasis in non-small cell lung cancer., PMID:24584816

Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells., PMID:24357068

Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer., PMID:23825230

Homing of human B cells to lymphoid organs and B-cell lymphoma engraftment are controlled by cell adhesion molecule JAM-C., PMID:23221386

The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis., PMID:23068611

Targeting of junctional adhesion molecule-C inhibits experimental choroidal neovascularization., PMID:22323465

JAM-C is an apical surface marker for neural stem cells., PMID:22114908

Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves., PMID:22090315

Neutrophils, reverse traffic and detrimental potential., PMID:21874043

JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow., PMID:21868569

Tight junction proteins expression and modulation in immune cells and multiple sclerosis., PMID:21762372

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo., PMID:21706006

Cutting edge: JAM-C controls homeostatic chemokine secretion in lymph node fibroblastic reticular cells expressing thrombomodulin., PMID:21685324

A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis., PMID:21593193

Junctional adhesion molecules are required for melanoma cell lines transendothelial migration in vitro., PMID:21466663

Neuroscience. Ubiquitination inhibits neuronal exit., PMID:21205656

Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit., PMID:21109632

Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events., PMID:20215637

Cooperative expression of junctional adhesion molecule-C and -B supports growth and invasion of glioma., PMID:19795504

Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin., PMID:19740376

Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury., PMID:19574560

Importance of junctional adhesion molecule-C for neointimal hyperplasia and monocyte recruitment in atherosclerosis-prone mice-brief report., PMID:19520977

Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory., PMID:19342649

Evidence for cross-reactivity of JAM-C antibodies: implications for cellular localization studies., PMID:19143587

Genetic deletion of JAM-C reveals a role in myeloid progenitor generation., PMID:19109565

Expression, localization, and function of junctional adhesion molecule-C (JAM-C) in human retinal pigment epithelium., PMID:19060272

Junctional adhesion molecule C mediates leukocyte adhesion to rheumatoid arthritis synovium., PMID:18821692

[JAM-C, adhesion molecule or intercellular junctional organizer: lessons from knock-out mice]., PMID:18789204

Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice., PMID:18055550

Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves., PMID:18048693

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