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Anti-Mouse MADCAM1 Polyclonal Antibody

Catalog #:   PMG54901 Specific References (100) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: Q61826
Overview

Catalog No.

PMG54901

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse MADCAM1 (Gln22-Ser222).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (mMAdCAM-1)

Purification

Purified by antigen affinity column.

Accession

Q61826

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • Western Blot
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with MADCAM1 antibody (PMG54901) at 1 μg/ml.

    Lane 1: Recombinant protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 24 kDa
    Observed MW: 24 kDa
References

Gut-directed therapeutics in inflammatory bowel disease., PMID:40305008

Gut-directed therapeutics in inflammatory bowel disease., PMID:40305008

Mucosal Addressin Cell Adhesion Molecule-1 Mediates T Cell Migration into Pancreas-Draining Lymph Nodes for Initiation of the Autoimmune Response in Type 1 Diabetes., PMID:39518902

Mucosal Addressin Cell Adhesion Molecule-1 Mediates T Cell Migration into Pancreas-Draining Lymph Nodes for Initiation of the Autoimmune Response in Type 1 Diabetes., PMID:39518902

Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer., PMID:39438458

Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer., PMID:39438458

Predictors of the efficacy of vedolizumab in patients with ulcerative colitis., PMID:39355361

Predictors of the efficacy of vedolizumab in patients with ulcerative colitis., PMID:39355361

miR-200c-3p regulates α4 integrin-mediated T cell adhesion and migration., PMID:38936759

miR-200c-3p regulates α4 integrin-mediated T cell adhesion and migration., PMID:38936759

MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype., PMID:38729611

MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype., PMID:38729611

Selective Targeting of α4β7/MAdCAM-1 Axis Suppresses Fibrosis Progression by Reducing Proinflammatory T Cell Recruitment to the Liver., PMID:38727292

Selective Targeting of α4β7/MAdCAM-1 Axis Suppresses Fibrosis Progression by Reducing Proinflammatory T Cell Recruitment to the Liver., PMID:38727292

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis., PMID:38640252

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis., PMID:38640252

Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis., PMID:38604270

Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis., PMID:38604270

Vedolizumab Does Not Affect Antibody Secreting Cell Recruitment to the Lactating Mammary Gland of Mothers With Inflammatory Bowel Disease., PMID:38334263

Vedolizumab Does Not Affect Antibody Secreting Cell Recruitment to the Lactating Mammary Gland of Mothers With Inflammatory Bowel Disease., PMID:38334263

NGFR regulates stromal cell activation in germinal centers., PMID:38307025

NGFR regulates stromal cell activation in germinal centers., PMID:38307025

Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo., PMID:38243565

Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo., PMID:38243565

Efficacy and Safety of the Anti-mucosal Addressin Cell Adhesion Molecule-1 Antibody Ontamalimab in Patients with Moderate-to-Severe Ulcerative Colitis or Crohn's Disease., PMID:38096402

Efficacy and Safety of the Anti-mucosal Addressin Cell Adhesion Molecule-1 Antibody Ontamalimab in Patients with Moderate-to-Severe Ulcerative Colitis or Crohn's Disease., PMID:38096402

The Force-Dependent Mechanism of an Integrin α4β7-MAdCAM-1 Interaction., PMID:38003252

The Force-Dependent Mechanism of an Integrin α4β7-MAdCAM-1 Interaction., PMID:38003252

Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells., PMID:37837660

Vedolizumab Efficacy Is Associated With Decreased Intracolonic Dendritic Cells, Not Memory T Cells., PMID:37837660

Machine Learning-Based Quantification of Patient Factors Impacting Remission in Patients With Ulcerative Colitis: Insights from Etrolizumab Phase III Clinical Trials., PMID:37828747

Machine Learning-Based Quantification of Patient Factors Impacting Remission in Patients With Ulcerative Colitis: Insights from Etrolizumab Phase III Clinical Trials., PMID:37828747

MAdCAM-1 targeting strategy can prevent colitic cancer carcinogenesis and progression via suppression of immune cell infiltration and inflammatory signals., PMID:37676657

MAdCAM-1 targeting strategy can prevent colitic cancer carcinogenesis and progression via suppression of immune cell infiltration and inflammatory signals., PMID:37676657

An update on the safety of long-term vedolizumab use in inflammatory bowel disease., PMID:37610086

An update on the safety of long-term vedolizumab use in inflammatory bowel disease., PMID:37610086

Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma., PMID:37531415

Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma., PMID:37531415

Mucosal α4β7+ Lymphocytes and MAdCAM+ Venules Predict Response to Vedolizumab in Ulcerative Colitis., PMID:37436917

Mucosal α4β7+ Lymphocytes and MAdCAM+ Venules Predict Response to Vedolizumab in Ulcerative Colitis., PMID:37436917

A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers., PMID:37289890

A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers., PMID:37289890

Differential Effects of Ontamalimab Versus Vedolizumab on Immune Cell Trafficking in Intestinal Inflammation and Inflammatory Bowel Disease., PMID:37208197

Differential Effects of Ontamalimab Versus Vedolizumab on Immune Cell Trafficking in Intestinal Inflammation and Inflammatory Bowel Disease., PMID:37208197

A pediatric case of infliximab-resistant ulcerative colitis successfully treated using vedolizumab., PMID:37164738

A pediatric case of infliximab-resistant ulcerative colitis successfully treated using vedolizumab., PMID:37164738

Transcriptional derepression of CHD4/NuRD-regulated genes in the muscle of patients with dermatomyositis and anti-Mi2 autoantibodies., PMID:37130727

Transcriptional derepression of CHD4/NuRD-regulated genes in the muscle of patients with dermatomyositis and anti-Mi2 autoantibodies., PMID:37130727

Anti-β7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing., PMID:37029786

Anti-β7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing., PMID:37029786

Salmonella infection induces the reorganization of follicular dendritic cell networks concomitant with the failure to generate germinal centers., PMID:36950118

Salmonella infection induces the reorganization of follicular dendritic cell networks concomitant with the failure to generate germinal centers., PMID:36950118

The Underappreciated Role of Secretory IgA in IBD., PMID:36943800

The Underappreciated Role of Secretory IgA in IBD., PMID:36943800

Cost effective and reliable cell based ELISA as an alternative method of flow cytometry for assessment of binding activity of Vedolizumab., PMID:36865445

Cost effective and reliable cell based ELISA as an alternative method of flow cytometry for assessment of binding activity of Vedolizumab., PMID:36865445

Selective targeting of α 4 β 7 /MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver., PMID:36865167

Selective targeting of α 4 β 7 /MAdCAM-1 axis suppresses liver fibrosis by reducing proinflammatory T cell recruitment to the liver., PMID:36865167

MAdCAM-1 does not play a central role in the early pathophysiology of autoimmune hepatitis., PMID:36841352

MAdCAM-1 does not play a central role in the early pathophysiology of autoimmune hepatitis., PMID:36841352

Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation., PMID:36672684

Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation., PMID:36672684

Fibroblastic reticular cells orchestrate long-term graft survival following recipient treatment with CD40 ligand-targeted costimulatory blockade., PMID:36519546

Fibroblastic reticular cells orchestrate long-term graft survival following recipient treatment with CD40 ligand-targeted costimulatory blockade., PMID:36519546

Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease., PMID:36272713

Expression and function of α4β7 integrin predict the success of vedolizumab treatment in inflammatory bowel disease., PMID:36272713

Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes., PMID:36045707

Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes., PMID:36045707

Serological biomarkers for management of primary sclerosing cholangitis., PMID:35800183

Serological biomarkers for management of primary sclerosing cholangitis., PMID:35800183

Vedolizumab blocks α4β7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis., PMID:35784193

Vedolizumab blocks α4β7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis., PMID:35784193

Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response., PMID:35522725

Targeting TLR4 during vaccination boosts MAdCAM-1+ lymphoid stromal cell activation and promotes the aged germinal center response., PMID:35522725

Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro., PMID:35349682

Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro., PMID:35349682

α4β7 integrin-dependent adhesion of T cells to MAdCAM-1 is blocked by vedolizumab in patients with chronic refractory pouchitis., PMID:34868349

α4β7 integrin-dependent adhesion of T cells to MAdCAM-1 is blocked by vedolizumab in patients with chronic refractory pouchitis., PMID:34868349

Alterations in MAdCAM1-Positive Mucosal Capillaries and Integrin a4b7-Positive Lymphocytes in Crohn's Disease Treated with Anti-TNFα Biologics., PMID:34686510

Alterations in MAdCAM1-Positive Mucosal Capillaries and Integrin a4b7-Positive Lymphocytes in Crohn's Disease Treated with Anti-TNFα Biologics., PMID:34686510

Clinical response of vedolizumab at week 6 predicted endoscopic remission at week 24 in ulcerative colitis., PMID:34584975

Clinical response of vedolizumab at week 6 predicted endoscopic remission at week 24 in ulcerative colitis., PMID:34584975

Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis., PMID:34433904

Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis., PMID:34433904

sMAdCAM: IL-6 Ratio Influences Disease Progression and Anti-Viral Responses in SARS-CoV-2 Infection., PMID:34194420

sMAdCAM: IL-6 Ratio Influences Disease Progression and Anti-Viral Responses in SARS-CoV-2 Infection., PMID:34194420

Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation., PMID:33932356

Optogenetic activation of local colonic sympathetic innervations attenuates colitis by limiting immune cell extravasation., PMID:33932356

Safety and effectiveness of vedolizumab in paediatric patients with inflammatory bowel disease: an observational multicentre Spanish study., PMID:33880650

Safety and effectiveness of vedolizumab in paediatric patients with inflammatory bowel disease: an observational multicentre Spanish study., PMID:33880650

Dose optimisation for Loss of Response to Vedolizumab- Pharmacokinetics and Immune Mechanisms., PMID:33837762

Dose optimisation for Loss of Response to Vedolizumab- Pharmacokinetics and Immune Mechanisms., PMID:33837762

Long-term Safety and Efficacy of the Anti-MAdCAM-1 Monoclonal Antibody Ontamalimab [SHP647] for the Treatment of Ulcerative Colitis: The Open-label Study TURANDOT II., PMID:33599720

Long-term Safety and Efficacy of the Anti-MAdCAM-1 Monoclonal Antibody Ontamalimab [SHP647] for the Treatment of Ulcerative Colitis: The Open-label Study TURANDOT II., PMID:33599720

Tissue Exposure does not Explain Non-Response in Ulcerative Colitis Patients with Adequate Serum Vedolizumab Concentrations., PMID:33245363

Tissue Exposure does not Explain Non-Response in Ulcerative Colitis Patients with Adequate Serum Vedolizumab Concentrations., PMID:33245363

Anti-MAdCAM-1-Conjugated Nanocarriers Delivering Quantum Dots Enable Specific Imaging of Inflammatory Bowel Disease., PMID:33173291

Anti-MAdCAM-1-Conjugated Nanocarriers Delivering Quantum Dots Enable Specific Imaging of Inflammatory Bowel Disease., PMID:33173291

Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice., PMID:32908005

Ultrasensitive molecular imaging of intestinal mucosal inflammation using leukocyte-mimicking particles targeted to MAdCAM-1 in mice., PMID:32908005

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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Anti-Mouse MADCAM1 Polyclonal Antibody [PMG54901]
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