Catalog No.
PMC79001
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse GZMB (Ser31-Ser247).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Granzyme B(G,H) (EC 3.4.21.79) (CTLA-1) (Cytotoxic cell protease 1) (CCP1) (Fragmentin-2),grzmB
Purification
Purified by antigen affinity column.
Accession
P04187
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Immune profiling of kidney transplant recipients: the role of Tribbles-1, Perforin, and Granzyme B in chronic humoral rejection., PMID:40488991
Impact of immune checkpoint TIGIT on the activation and function of natural killer cells in rheumatoid arthritis patients., PMID:40465407
Inhibition of UCH-L1 enhances immunotherapy efficacy in triple-negative breast cancer by stabilizing PD-L1., PMID:40389130
Novel diagnostic biomarker and immune profiling of GPR56+ B cell subsets in systemic lupus erythematosus., PMID:40311320
Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8+T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung cancer mice., PMID:40241108
Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects., PMID:40216443
T-cell-derived IFN-γ suppresses T follicular helper cell differentiation and antibody responses., PMID:40169810
Single cell multi-omics reveals re-dosing with CD3 bispecific antibody induces a TCF7 high central memory CD8 + T cell population associated with reduced cytokine production., PMID:40168725
ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA., PMID:39808660
Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses., PMID:39806065
Strengthening Effect of Thalidomide Combined with an Anti-PD1 Antibody on Enhancing Immunity for Lung Cancer Therapy., PMID:39773053
Baicalein tethers CD274/PD-L1 for autophagic degradation to boost antitumor immunity., PMID:39710370
P2RX1-blocked neutrophils induce CD8+ T cell dysfunction and affect the immune escape of gastric cancer cells., PMID:39675308
The Absence of CXCL10 Activity Does Not Affect the Capability of CD8+ T Cells to Migrate and Eliminate the Tissue Cysts of Toxoplasma gondii from the Brains of Chronically Infected Mice., PMID:39597561
Anti-PTHrP blockade limits CD8+ T-cell exhaustion in anti-cancer immunotherapy., PMID:39554058
Methionine restriction promotes the polarization of macrophages towards M1 and the immunotherapy effect of PD-L1/PD-1 blockades by inhibiting the secretion of MIF by gastric carcinoma cells., PMID:39541710
Snapshot Moments of the Cell Revealed by UV-Crosslinking and RNA Co-immunoprecipitation of Transient RNA-Protein Complexes., PMID:39535714
Degradation fragments of Tau and type IV collagen as serum biomarkers in patients with recurrent glioblastoma treated with nivolumab and bevacizumab., PMID:39499486
Pharmacological activation of STAT1-GSDME pyroptotic circuitry reinforces epigenetic immunotherapy for hepatocellular carcinoma., PMID:39486886
[A study on the effects of Anti-GM1 on the differentiation and cytotoxic activity of NK cells in nude mice]., PMID:39442965
The prognostic and therapeutic value of the tumor microenvironment and immune checkpoints in pancreatic neuroendocrine neoplasms., PMID:39433799
DSP-0509, a TLR7 agonist, exerted synergistic anti-tumor immunity combined with various immune therapies through modulating diverse immune cells in cancer microenvironment., PMID:39346737
Identification of antibody-resistant SARS-CoV-2 mutants via N4-Hydroxycytidine mutagenesis., PMID:39293594
Granzyme B inhibition reduces autoantibody-induced dermal-epidermal separation in an ex vivo model of epidermolysis bullosa acquisita., PMID:39219105
Evaluation of non-invasive biomarkers of kidney allograft rejection in a prospective multicenter unselected cohort study (EU-TRAIN)., PMID:39197587
Antitumor effects of IOX1 combined with bevacizumab-induced apoptosis and immunity on colorectal cancer cells., PMID:39146782
RAS-Selective Lethal 3-Induced Ferroptosis Promotes the Antitumor Efficiency of Anti-Programmed Cell Death Protein 1 Treatment in Colorectal Cancer., PMID:39128094
Regulatory B Cells Expressing Granzyme B from Tolerant Renal Transplant Patients: Highly Differentiated B Cells with a Unique Pathway with a Specific Regulatory Profile and Strong Interactions with Immune System Cells., PMID:39120317
Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway., PMID:38974523
Identification of different functions of CD8+ T cell subpopulations by a novel monoclonal antibody., PMID:38922845
CD8+ tissue-resident memory T cells are expanded in primary Sjögren's disease and can be therapeutically targeted by CD103 blockade., PMID:38777379
Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases., PMID:38751645
Hypofractionated radiotherapy combined with lenalidomide improves systemic antitumor activity in mouse solid tumor models., PMID:38646638
Dual-Responsive Nanomedicine Activates Programmed Antitumor Immunity through Targeting Lymphatic System., PMID:38639726
Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines., PMID:38570727
Modulating Cholesterol Metabolism via ACAT1 Knockdown Enhances Anti-B-Cell Lymphoma Activities of CD19-Specific Chimeric Antigen Receptor T Cells by Improving the Cell Activation and Proliferation., PMID:38534399
An international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer., PMID:38519913
Final results of urelumab, an anti-CD137 agonist monoclonal antibody, in combination with cetuximab or nivolumab in patients with advanced solid tumors., PMID:38458639
Synthetic Antimicrobial Peptides Fail to Induce Leucocyte Innate Immune Functions but Elicit Opposing Transcriptomic Profiles in European Sea Bass and Gilthead Seabream., PMID:38393057
Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells., PMID:38324679
Melanoma Derived Exosomes Amplify Radiotherapy Induced Abscopal Effect via IRF7/I-IFN Axis in Macrophages., PMID:38286661
Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma., PMID:38245530
Immune characteristics of kidney transplant recipients with acute respiratory distress syndrome induced by COVID-19 at single-cell resolution., PMID:38238762
Granzyme B promotes matrix metalloproteinase-1 (MMP-1) release from gingival fibroblasts in a PAR1- and Erk1/2-dependent manner: A novel role in periodontal inflammation., PMID:37873693
In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity., PMID:37790917
Case report: Granzyme-B expression by T- and B- cells during severe AQP4-positive Neuromyelitis Optica spectrum disorder with fatal venous thromboembolism outcome., PMID:37662034
Immune dysfunction revealed by digital spatial profiling of immuno-oncology markers in progressive stages of renal cell carcinoma and in brain metastases., PMID:37586773
Dual inhibition of BTLA and PD-1 can enhance therapeutic efficacy of paclitaxel on intraperitoneally disseminated tumors., PMID:37463789
Noninvasive quantification of granzyme B in cardiac allograft rejection using targeted ultrasound imaging., PMID:37435082
Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy., PMID:37258621
For research use only. Not for human or drug use.
