Anti-Mouse CTSB Polyclonal Antibody

Catalog No.

PMC27901

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CTSB (Asp51-Phe339).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Cathepsin B (EC 3.4.22.1) (Cathepsin B1) [Cleaved into: Cathepsin B light chain, Cathepsin B heavy chain]

Purification

Purified by antigen affinity column.

Accession

P10605

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Salmonella Typhi serine threonine kinase T4519 induces lysosomal membrane permeabilization by manipulating Toll-like receptor 2-Cystatin B-Cathepsin B-NF-κB-reactive oxygen species pathway and promotes survival within human macrophages., PMID:40168426

Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1., PMID:39894408

Cathepsin B modulates microglial migration and phagocytosis of amyloid β in Alzheimer's disease through PI3K-Akt signaling., PMID:39304744

Synthesis and Evaluation of a Cathepsin B-Recognizing Trifunctional Chelating Agent to Improve Tumor Retention of Radioimmunoconjugates., PMID:38837480

Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity., PMID:38342757

Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma., PMID:37598461

The effects of a 20-week exercise program on blood-circulating biomarkers related to brain health in overweight or obese children: The ActiveBrains project., PMID:36529369

Cathepsin B-A Neuronal Death Mediator in Alzheimer's Disease Leading to Neurodegeneration., PMID:35156579

Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates., PMID:34894942

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization., PMID:34802379

Interruption of endolysosomal trafficking leads to stroke brain injury., PMID:34363809

Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective antibreast cancer therapy., PMID:34083420

Influence of lysosomal protease sensitivity in the immunogenicity of the antitumor biopharmaceutical asparaginase., PMID:32979352

Role of major histocompatibility complex II antigen-presentation pathway genes in orange-spotted grouper infected with Cryptocaryon irritans., PMID:32924190

Pharmacokinetics and Catabolism of [3H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate., PMID:32843329

Rational Design of a Humanized Antibody Inhibitor of Cathepsin B., PMID:32212642

Evaluation of Quantitative Relationship Between Target Expression and Antibody-Drug Conjugate Exposure Inside Cancer Cells., PMID:32086295

C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease., PMID:31092553

Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion., PMID:30622337

Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation., PMID:30019185

TRAIL DR5-CTSB crosstalk participates in breast cancer autophagy initiated by SAHA., PMID:29018571

mRNA Expression of Bax, Bcl-2, p53, Cathepsin B, Caspase-3 and Caspase-9 in the HepG2 Cell Line Following Induction by a Novel Monoclonal Ab Hep88 mAb: Cross-Talk for Paraptosis and Apoptosis., PMID:26925667

HIV-infected microglia mediate cathepsin B-induced neurotoxicity., PMID:26092112

Antithymocyte globulin facilitates alloreactive T-cell apoptosis by means of caspase-3: potential implications for monitoring rejection-free outcomes., PMID:25531894

Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages., PMID:25209871

Proteases as activators for cytotoxic prodrugs in antitumor therapy., PMID:24709544

Abundance of MMPs and cysteine cathepsins in caries-affected dentin., PMID:24356440

Endo-PDI is required for TNFα-induced angiogenesis., PMID:24103565

Inflammatory and immunological biomarkers are not related to survival in adults with Cystic Fibrosis., PMID:23860440

Influence of partial unfolding and aggregation of human stefin B (cystatin B) EPM1 mutants G50E and Q71P on selective cleavages by cathepsins B and S., PMID:23362198

Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis., PMID:21421874

Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice., PMID:20133781

Interleukin-6 increases expression and secretion of cathepsin B by breast tumor-associated monocytes., PMID:20110692

Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae., PMID:20107207

Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush., PMID:18775855

Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer., PMID:16707449

Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma., PMID:15367886

Angiogenesis and cathepsin expression are prognostic factors in pancreatic adenocarcinoma after curative resection., PMID:11185708

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