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Anti-Mouse CD115/CSF1R Polyclonal Antibody

Catalog #:   PMC25201 Specific References (99) DATASHEET
Host species: Rabbit
Isotype: IgG
Applications: ELISA, IHC, WB
Accession: P09581
Overview

Catalog No.

PMC25201

Species reactivity

Mouse

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CD115/CSF1R (Val22-Val198).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)

Purification

Purified by antigen affinity column.

Accession

P09581

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Data Image
  • WESTERN BLOT
    Various lysates were subjected to SDS PAGE followed by western blot with CSF1R antibody (PMC25201) at 1µg/ml.

    Lane 1: THP-1 cell lysate

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 109 kDa
    Observed MW: 52 kDa
  • Western Blot
    Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with CD115/CSF1R antibody (PMC25201) at 1 µg/ml.

    Lane 1: Recombinant Protein

    Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

    Predict MW: 22 kDa
    Observed MW: 22 kDa
References

RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ., PMID:40512793

RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ., PMID:40512793

cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy., PMID:40444360

cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy., PMID:40444360

Targeted Reprogramming of TREM2-Positive Macrophages and MRI-Guided Immune Monitoring in Colorectal Cancer Using CSF1R@Mn@MPDA-Antitrem2 Nanoplatform., PMID:40417930

Targeted Reprogramming of TREM2-Positive Macrophages and MRI-Guided Immune Monitoring in Colorectal Cancer Using CSF1R@Mn@MPDA-Antitrem2 Nanoplatform., PMID:40417930

Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial., PMID:40389374

Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial., PMID:40389374

Multiplatform molecular analyses reveal two molecular subgroups of NF2-related schwannomatosis vestibular schwannomas with distinct tumour microenvironment and therapeutic vulnerabilities., PMID:40343504

Multiplatform molecular analyses reveal two molecular subgroups of NF2-related schwannomatosis vestibular schwannomas with distinct tumour microenvironment and therapeutic vulnerabilities., PMID:40343504

Evaluating Axatilimab as a treatment option for chronic graft-versus-host disease., PMID:40338737

Evaluating Axatilimab as a treatment option for chronic graft-versus-host disease., PMID:40338737

New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma., PMID:40101804

New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma., PMID:40101804

TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells., PMID:40023455

TLR-4Ab and IFNγAb with exogenous IL-10 treated LPS induced mice shown differential inflammatory response upon RANKL-M-CSF stimulation in resident bone marrow cells., PMID:40023455

Immunological biomarkers of response and resistance to treatment with cabozantinib and nivolumab in recurrent endometrial cancer., PMID:40010771

Immunological biomarkers of response and resistance to treatment with cabozantinib and nivolumab in recurrent endometrial cancer., PMID:40010771

Silencing TGF-β3 Alleviates Recurrent Spontaneous Abortion Inflammation in Mice: the Importance of Treg/Th17 Cell Balance., PMID:39973551

Silencing TGF-β3 Alleviates Recurrent Spontaneous Abortion Inflammation in Mice: the Importance of Treg/Th17 Cell Balance., PMID:39973551

Lower expression of colony-stimulating factor 2, an embryokine, in the endometrial epithelium of old cows., PMID:39951370

Lower expression of colony-stimulating factor 2, an embryokine, in the endometrial epithelium of old cows., PMID:39951370

Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism., PMID:39891235

Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism., PMID:39891235

Sustained inhibition of CSF1R signaling augments antitumor immunity through inhibiting tumor-associated macrophages., PMID:39782686

Sustained inhibition of CSF1R signaling augments antitumor immunity through inhibiting tumor-associated macrophages., PMID:39782686

Metabolic Stress Expands Polyfunctional, Proinflammatory Th17 Cells in Patients With Psoriatic Arthritis for Whom There is Interleukin-23-Independent Interleukin-17 Production., PMID:39711043

Metabolic Stress Expands Polyfunctional, Proinflammatory Th17 Cells in Patients With Psoriatic Arthritis for Whom There is Interleukin-23-Independent Interleukin-17 Production., PMID:39711043

Semimechanistic Population PK/PD Modeling of Axatilimab in Healthy Participants and Patients With Solid Tumors or Chronic Graft-Versus-Host Disease., PMID:39704205

Semimechanistic Population PK/PD Modeling of Axatilimab in Healthy Participants and Patients With Solid Tumors or Chronic Graft-Versus-Host Disease., PMID:39704205

CD226 + adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism., PMID:39677815

CD226 + adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism., PMID:39677815

Evolution of myeloid-mediated immunotherapy resistance in prostate cancer., PMID:39633050

Evolution of myeloid-mediated immunotherapy resistance in prostate cancer., PMID:39633050

The contribution of the monocyte-macrophage lineage to immunotherapy outcomes., PMID:39576958

Myeloid subsets impede the efficacy of anti-PD1 therapy in patients with advanced gastric cancer (WJOG10417GTR study)., PMID:39489543

The contribution of the monocyte-macrophage lineage to immunotherapy outcomes., PMID:39576958

Clinical approach for pulmonary alveolar proteinosis in children., PMID:39464322

Clinical approach for pulmonary alveolar proteinosis in children., PMID:39464322

AKAP12 positive fibroblast determines immunosuppressive contexture and immunotherapy response in patients with TNBC by promoting macrophage M2 polarization., PMID:39448199

AKAP12 positive fibroblast determines immunosuppressive contexture and immunotherapy response in patients with TNBC by promoting macrophage M2 polarization., PMID:39448199

Inhibition of CEACAM1 expression in cytokine-activated neutrophils using JAK inhibitors., PMID:39354368

Inhibition of CEACAM1 expression in cytokine-activated neutrophils using JAK inhibitors., PMID:39354368

CSF1R Blockade for Refractory Chronic Graft-versus-Host Disease., PMID:39292933

CSF1R Blockade for Refractory Chronic Graft-versus-Host Disease., PMID:39292933

Targeting CSF1R in Chronic GVHD - Lessons in Translation., PMID:39292932

Targeting CSF1R in Chronic GVHD - Lessons in Translation., PMID:39292932

Axatilimab in Recurrent or Refractory Chronic Graft-versus-Host Disease., PMID:39292927

Axatilimab in Recurrent or Refractory Chronic Graft-versus-Host Disease., PMID:39292927

CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages., PMID:39168451

CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages., PMID:39168451

Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R., PMID:39153324

Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R., PMID:39153324

Suppressing anti-citrullinated protein antibody-induced osteoclastogenesis in rheumatoid arthritis using anti-CD64 and PAD-2 inhibitors., PMID:39152765

Suppressing anti-citrullinated protein antibody-induced osteoclastogenesis in rheumatoid arthritis using anti-CD64 and PAD-2 inhibitors., PMID:39152765

Pathogenesis-driven treatment of primary pulmonary alveolar proteinosis., PMID:39142709

Pathogenesis-driven treatment of primary pulmonary alveolar proteinosis., PMID:39142709

Amplification of autoimmune organ damage by NKp46-activated ILC1s., PMID:39137897

Amplification of autoimmune organ damage by NKp46-activated ILC1s., PMID:39137897

Plonmarlimab, a novel anti-GM-CSF blocking antibody, ameliorates disease progression in the pre-clinical model of macrophage activation syndrome., PMID:39095968

Plonmarlimab, a novel anti-GM-CSF blocking antibody, ameliorates disease progression in the pre-clinical model of macrophage activation syndrome., PMID:39095968

Vaccination with folate receptor-alpha peptides in patients with ovarian cancer following response to platinum-based therapy: A randomized, multicenter clinical trial., PMID:39068739

Vaccination with folate receptor-alpha peptides in patients with ovarian cancer following response to platinum-based therapy: A randomized, multicenter clinical trial., PMID:39068739

oHSV2-mGM repolarizes TAMs and cooperates with αPD1 to reprogram the immune microenvironment of residual cancer after radiofrequency ablation., PMID:39053421

oHSV2-mGM repolarizes TAMs and cooperates with αPD1 to reprogram the immune microenvironment of residual cancer after radiofrequency ablation., PMID:39053421

CD150‑dependent activation of EBV‑transformed B cells induces the differentiation of peripheral blood monocytes via the secretion of multiple cytokines., PMID:39027993

CD150‑dependent activation of EBV‑transformed B cells induces the differentiation of peripheral blood monocytes via the secretion of multiple cytokines., PMID:39027993

Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells., PMID:39027912

Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells., PMID:39027912

Functional Fc receptors are crucial in antibody-mediated protection against cytomegalovirus., PMID:39014923

Functional Fc receptors are crucial in antibody-mediated protection against cytomegalovirus., PMID:39014923

Pexidartinib and Immune Checkpoint Inhibitors Combine to Activate Tumor Immunity in a Murine Colorectal Cancer Model by Depleting M2 Macrophages Differentiated by Cancer-Associated Fibroblasts., PMID:39000110

Pexidartinib and Immune Checkpoint Inhibitors Combine to Activate Tumor Immunity in a Murine Colorectal Cancer Model by Depleting M2 Macrophages Differentiated by Cancer-Associated Fibroblasts., PMID:39000110

Race-Related Differences in Sipuleucel-T Response among Men with Metastatic Castrate-Resistant Prostate Cancer., PMID:38856749

Race-Related Differences in Sipuleucel-T Response among Men with Metastatic Castrate-Resistant Prostate Cancer., PMID:38856749

Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor., PMID:38849345

Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor., PMID:38849345

Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells., PMID:38713511

Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells., PMID:38713511

Tumor microenvironment restricts IL-10 induced multipotent progenitors to myeloid-lymphatic phenotype., PMID:38640116

Tumor microenvironment restricts IL-10 induced multipotent progenitors to myeloid-lymphatic phenotype., PMID:38640116

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma: A case report., PMID:38577174

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma: A case report., PMID:38577174

Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization., PMID:38489007

Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization., PMID:38489007

pGM-CSF as an adjuvant in DNA vaccination against SARS-CoV-2., PMID:38460634

pGM-CSF as an adjuvant in DNA vaccination against SARS-CoV-2., PMID:38460634

Parasite-induced IFN-γ regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death., PMID:38377133

Parasite-induced IFN-γ regulates host defense via CD115 and mTOR-dependent mechanism of tissue-resident macrophage death., PMID:38377133

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis., PMID:38342894

IGF-1R mediates crosstalk between nasopharyngeal carcinoma cells and osteoclasts and promotes tumor bone metastasis., PMID:38342894

The CSF-1R inhibitor pexidartinib affects FLT3-dependent DC differentiation and may antagonize durvalumab effect in patients with advanced cancers., PMID:38266104

The CSF-1R inhibitor pexidartinib affects FLT3-dependent DC differentiation and may antagonize durvalumab effect in patients with advanced cancers., PMID:38266104

Ten-year experience of whole lung lavage in pediatric Pulmonary Alveolar Proteinosis., PMID:38262422

Ten-year experience of whole lung lavage in pediatric Pulmonary Alveolar Proteinosis., PMID:38262422

Anti-PD-L1 therapy altered inflammation but not survival in a lethal murine hepatitis virus-1 pneumonia model., PMID:38259435

Anti-PD-L1 therapy altered inflammation but not survival in a lethal murine hepatitis virus-1 pneumonia model., PMID:38259435

Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching., PMID:38225394

Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching., PMID:38225394

Datasheet
$ 170
Product specifications
50 μg 170 100 μg 280

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For research use only. Not for human or drug use.

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Anti-Mouse CD115/CSF1R Polyclonal Antibody [PMC25201]
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