Catalog No.
PMB10201
Species reactivity
Mouse
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Mouse CD275/ICOSLG (Glu47-Gln258).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD antigen CD275)
Purification
Purified by antigen affinity column.
Accession
Q9JHJ8
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Aire attenuate collagen-induced arthritis by suppressing T follicular helper cells through ICOSL., PMID:39626537
CD34+ and CD34- MM cells show different immune-checkpoint molecule expression profiles: high expression of CD112 and CD137 ligand on CD34+ MM cells., PMID:39531203
Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion., PMID:33459589
Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies., PMID:33033255
Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts., PMID:32049348
Acute Myeloid Leukemia Cells Express ICOS Ligand to Promote the Expansion of Regulatory T Cells., PMID:30319662
B cells are required for sunlight protection of mice from a CNS-targeted autoimmune attack., PMID:27289166
Autoantibody-Mediated Pulmonary Alveolar Proteinosis in Rasgrp1-Deficient Mice., PMID:27279372
Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy., PMID:27246829
ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40-Mediated Tumor Rejection., PMID:27197182
CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice., PMID:27183569
Development of a novel monoclonal antibody to human inducible co-stimulator ligand (ICOSL): Biological characteristics and application for enzyme-linked immunosorbent assay., PMID:27138044
Development of a Novel Functional Monoclonal Antibody to Human CD275: Characterization and Biological Activity., PMID:26788906
Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand., PMID:25210803
CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy., PMID:24778280
B7h triggering inhibits the migration of tumor cell lines., PMID:24729612
Impaired ICOSL in human myeloid dendritic cells promotes Th2 responses in patients with allergic rhinitis and asthma., PMID:24661627
Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria., PMID:23874969
A novel anti-human ICOSL monoclonal antibody that enhances IgG production of B cells., PMID:23607348
Triggering of B7h by the ICOS modulates maturation and migration of monocyte-derived dendritic cells., PMID:23275603
ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells., PMID:23026134
Involvement of inducible costimulator ligand (ICOSL) expression in thyroid tissue in hyperthyroidism of Graves' disease patients., PMID:22706735
ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation., PMID:22577174
Immunomodulation of inducible co-stimulator (ICOS) in human cytokine-induced killer cells against cholangiocarcinoma through ICOS/ICOS ligand interaction., PMID:21955433
Immunoreactivity of two novel monoclonal antibodies against human inducible co-stimulator ligand., PMID:21851236
HLA-G level on monocytoid dendritic cells correlates with regulatory T-cell Foxp3 expression in liver transplant tolerance., PMID:21423069
Costimulatory signals potently modulate the T cell inhibitory capacity of the therapeutic CD11a antibody Efalizumab., PMID:21414849
The regulation of T-cell cytokine production by ICOS-B7H2 interactions at the human fetomaternal interface., PMID:20733594
Stromal cells' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT, a multifunctional regulatory T-cell line., PMID:20628373
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones., PMID:20231422
The role of costimulation in antibody deficiencies: ICOS and common variable immunodeficiency., PMID:19426217
Mapping of the ICOS binding surface of murine B7h using an unbiased, cellular library of B7h mutants created by cyclical packaging rescue., PMID:18294651
The expression analysis of ICOS-L on activated T cells and immature dendritic cells as well as malignant B cells and Grave's-disease-derived thyroid tissues by two novel mAbs against human ICOS-L., PMID:17212709
Detection of novel leukocyte differentiation antigens on basophils and mast cells by HLDA8 antibodies., PMID:16918507
Expression and regulation of human CD275 on endothelial cells in healthy and inflamed mucosal tissues., PMID:16499572
Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1., PMID:16221208
Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry., PMID:16157322
Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia., PMID:16115907
Migratory Langerhans cells in mouse lymph nodes in steady state and inflammation., PMID:15982311
Normal ICOS, ICOSL and AID alleles in Danish patients with common variable immunodeficiency., PMID:15963052
Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells., PMID:15961727
The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells., PMID:15131796
Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo., PMID:14603470
Adenovirus-mediated gene transfer of ICOSIg fusion protein ameliorates ongoing experimental autoimmune myocarditis., PMID:12718763
Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells., PMID:12707012
Muscle fibres and cultured muscle cells express the B7.1/2-related inducible co-stimulatory molecule, ICOSL: implications for the pathogenesis of inflammatory myopathies., PMID:12690043
ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells., PMID:12207353
ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cells., PMID:11983910
B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function., PMID:11238124
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS., PMID:11023515
For research use only. Not for human or drug use.
