Catalog No.
PHK90801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human ANO1 (Met117-Gly325).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Anoctamin-1, Tumor-amplified and overexpressed sequence 2, Transmembrane protein 16A, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, TMEM16A, ANO1, TAOS2, ORAOV2, DOG1
Purification
Purified by antigen affinity column.
Accession
Q5XXA6
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Functional roles of interstitial cells of Cajal in the GI tract of rats., PMID:40235202
A Cftr-independent, Ano1-rich seawater-adaptive ionocyte in sea lamprey gills., PMID:40007443
Co-targeting TMEM16A with a novel monoclonal antibody and EGFR with Cetuximab inhibits the growth and metastasis of esophageal squamous cell carcinoma., PMID:39563381
Gastrointestinal Stromal Tumors: Variants and Some Pitfalls That They Create., PMID:39466697
Involvement of TRPV4 in temperature-dependent perspiration in mice., PMID:38963781
Establishing an ANO1-Based Cell Model for High-Throughput Screening Targeting TRPV4 Regulators., PMID:38474548
Identification of potential molecular targets for the treatment of cluster 1 human pheochromocytoma and paraganglioma via comprehensive proteomic characterization., PMID:37749499
ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle., PMID:37702787
Establishment of a Cell Model for Dynamic Monitoring of Intracellular Calcium Concentration and High-Throughput Screening of P2Y2 Regulators., PMID:35566353
Anoctamin 1 and c-Kit immunohistochemical study of interstitial cells of Cajal in the muscularis externa of human gastrointestinal tract., PMID:35037698
DOG1 is commonly expressed in pancreatic adenocarcinoma but unrelated to cancer aggressiveness., PMID:34414034
Coronary hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1 in the arterial smooth muscle cells., PMID:34243598
TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation., PMID:33152928
TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection., PMID:33109690
Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling., PMID:32517157
Immunohistochemical analysis of 36 cases of chondroblastomas: A single institutional experience., PMID:31862519
ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion., PMID:31564164
Telocytes express ANO-1-encoded chloride channels in canine ventricular myocardium., PMID:31293701
A Novel Dual Immunostain to Characterize Sloughed Cells in Testicular Biopsies for Infertility., PMID:31094926
TMEM16A as a Potential Biomarker in the Diagnosis and Prognosis of Lung Cancer., PMID:30821158
Intraluminal pressure triggers myogenic response via activation of calcium spark and calcium-activated chloride channel in rat renal afferent arteriole., PMID:30089032
[Gastrointestinal leiomyoma with interstitial cells of Cajal: mimicker of gastrointestinal stromal tumor]., PMID:29886588
TMEM16A inhibition impedes capacitation and acquisition of hyperactivated motility in guinea pig sperm., PMID:29600587
Ultrastructural and Immunohistochemical Features of Telocytes in Placental Villi in Preeclampsia., PMID:29472628
Epithelial disruptions, but not immune cell invasion, induced secretory dysfunction following innate immune activation in a novel model of acute salivary gland injury., PMID:29160910
Expression of dog1 in low-grade fibromyxoid sarcoma: A study of 19 cases and review of the literature., PMID:28965630
[Gastrointestinal stromal tumor and renal transplant]., PMID:28825581
Circulating Biomarkers for Predicting Infliximab Response in Rheumatoid Arthritis: A Systematic Bioinformatics Analysis., PMID:28413214
TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2., PMID:28177558
Interstitial cell modulation of pyeloureteric peristalsis in the mouse renal pelvis examined using FIBSEM tomography and calcium indicators., PMID:28054154
The Diagnostic and Prognostic Utility of DOG1 Expression on Gastrointestinal Stromal Tumors., PMID:28044310
The stem cell growth factor receptor KIT is not expressed on interstitial cells in bladder., PMID:27997763
The presence and role of interstitial cells of Cajal in the proximal intestine of shorthorn sculpin (Myoxocephalus scorpius)., PMID:27875260
Transcriptional repression of HER2 by ANO1 Cl- channel inhibition in human breast cancer cells with resistance to trastuzumab., PMID:27838298
Effects of Exogenous Interleukin-9 on the Growth, Proliferation and Activity of Interstitial Cells of Cajal Cultured in vitro., PMID:27832662
Expression of DOG1 (Using SP31) in Poorly Differentiated Carcinoma of the Head and Neck., PMID:27272836
Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis., PMID:27217698
Telocytes (interstitial Cajal-like cells) in human Fallopian tubes., PMID:27215957
PDGFRA and KIT Mutation Status and Its Association With Clinicopathological Properties, Including DOG1., PMID:27178821
Is DOG1 Immunoreactivity Specific to Gastrointestinal Stromal Tumor?, PMID:26678977
Anoctamin 1 (Ano1) is required for glucose-induced membrane potential oscillations and insulin secretion by murine β-cells., PMID:26582426
Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung's disease., PMID:26510736
Correlation of angiogenesis with other immunohistochemical markers in cutaneous basal and squamous cell carcinomas., PMID:26429157
DOG1 Expression in Low-Grade Fibromyxoid Sarcoma: A Study of 11 Cases, With Molecular Characterization., PMID:26135531
Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats., PMID:26130088
Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin., PMID:26121472
Characterization of Cardiac Anoctamin1 Ca²⁺-Activated Chloride Channels and Functional Role in Ischemia-Induced Arrhythmias., PMID:24962810
Hypoxia augments the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice., PMID:24758567
The multiple expression of Ca²⁺-activated Cl⁻ channels via homo- and hetero-dimer formation of TMEM16A splicing variants in murine portal vein., PMID:24321548
Anoctamin 1 positive esophageal interstitial Cajal cells in late stage human embryos., PMID:24243583
For research use only. Not for human or drug use.
