Anti-Human UNC13D Polyclonal Antibody

Catalog No.

PHK87301

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human UNC13D (Ser888-Pro1090).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

Munc13-4, Protein unc-13 homolog D, UNC13D

Purification

Purified by antigen affinity column.

Accession

Q70J99

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Precise CRISPR-Cas9 gene repair in autologous memory T cells to treat familial hemophagocytic lymphohistiocytosis., PMID:38306418

Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791

Role of Genetic Polymorphism Present in Macrophage Activation Syndrome Pathway in Post Mortem Biopsies of Patients with COVID-19., PMID:36016321

UNC13D mutation in a patient with juvenile polymyositis with recurrent macrophage activation syndrome., PMID:33930104

Sensitivity analysis based on the random forest machine learning algorithm identifies candidate genes for regulation of innate and adaptive immune response of chicken., PMID:33248550

Randomized phase II clinical trial and biomarker analysis of paclitaxel plus epirubicin versus vinorelbine plus epirubicin as neoadjuvant chemotherapy in locally advanced HER2-negative breast cancer with TEKT4 variations., PMID:32975708

Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets., PMID:32582217

UNC13D Deficiency Associated With Epileptic Seizures and Antibody Deficiency: The First Case from the Iranian National Registry., PMID:31017122

Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury., PMID:26916731

[Natural killer cell cytotoxic activity in critical pediatric patients with suspected hemophagocytic syndrome]., PMID:25081072

Immunologic difference between hypersensitivity to mosquito bite and hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection., PMID:24204658

Prevalence of coinfection in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis., PMID:22146525

Ehrlichia chaffeensis TRP120 interacts with a diverse array of eukaryotic proteins involved in transcription, signaling, and cytoskeleton organization., PMID:21859857

Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases., PMID:20823128

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity., PMID:19704116

Munc13-4 regulates granule secretion in human neutrophils., PMID:18453599

Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways., PMID:18258655

Severe bacteria-associated hemophagocytic lymphohistiocytosis in an extremely premature infant., PMID:17888050

Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism., PMID:16762324

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