Catalog No.
PHG29701
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human KCNH2/ERG1 (Pro10-Lys135).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
H-ERG, ERG, HERG, hERG1, hERG-1, Potassium voltage-gated channel subfamily H member 2, ERG-1, KCNH2, Eag homolog, ERG1, Eag-related protein 1, Ether-a-go-go-related gene potassium channel 1, Voltage-gated potassium channel subunit Kv11.1, Ether-a-go-go-related protein 1
Purification
Purified by antigen affinity column.
Accession
Q12809
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Targeting the hERG1 and β1 integrin complex for cancer treatment., PMID:38372580
A rare case with fetal autoimmune heart block and KNCH2 variant-induced long QT syndrome: a controversial opinion on prenatal management strategy., PMID:36973673
KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression., PMID:36626562
Case Report: A novel KNCH2 variant-induced fetal heart block and the advantages of fetal genomic sequencing in prenatal long-term dexamethasone exposure., PMID:36523767
Cardiac ion channels associated with unexplained stillbirth - an immunohistochemical study., PMID:35731905
Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating., PMID:34716268
Stop codons and the +4 nucleotide may influence the efficiency of G418 in rescuing nonsense mutations of the HERG gene., PMID:31573043
Anti-Ro52 antibody acts on the S5-pore linker of hERG to chronically reduce channel expression., PMID:30544220
Metabolism of an Oxime-Linked Antibody Drug Conjugate, AGS62P1, and Characterization of Its Identified Metabolite., PMID:29757653
Proliferative Role of Kv11 Channels in Murine Arteries., PMID:28747891
Epigenome-wide DNA methylation study of IgE concentration in relation to self-reported allergies., PMID:28322575
Arrhythmogenicity of Anti-Ro/SSA Antibodies in Patients With Torsades de Pointes., PMID:27030700
Reduced expression of voltage-gated Kv11.1 (hERG) K(+) channels in aganglionic colon in Hirschsprung's disease., PMID:26519040
Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome., PMID:25995318
Berberine induces hERG channel deficiency through trafficking inhibition., PMID:25171176
Endocytosis of HERG is clathrin-independent and involves arf6., PMID:24392021
[Effect of berberine, liensinine and neferine on HERG channel expression]., PMID:23672049
Generation of an antibody toolbox to characterize hERG., PMID:23277102
A novel missense mutation causing a G487R substitution in the S2-S3 loop of human ether-à-go-go-related gene channel., PMID:22764740
The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel., PMID:22107967
Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG)., PMID:21536683
BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart., PMID:21205913
The EGFP/hERG fusion protein alter the electrophysiological properties of hERG channels in HEK293 cells., PMID:21143190
Antineoplastic chemotherapy induced QTc prolongation., PMID:20210725
Voltage-gated potassium channels as therapeutic targets., PMID:19949402
Erg K+ currents modulate excitability in mouse mitral/tufted neurons., PMID:19688350
Blockade of HERG K+ channel by isoquinoline alkaloid neferine in the stable transfected HEK293 cells., PMID:19424681
Electrophysiological and fluorescence microscopy studies with HERG channel/EGFP fusion proteins., PMID:18414922
HERG K+ channel blockade by the novel antiviral drug sophocarpine., PMID:18379053
Anti-KCNH2 antibody-induced long QT syndrome: novel acquired form of long QT syndrome., PMID:17964047
Differential association between HERG and KCNE1 or KCNE2., PMID:17895974
[Effects of matrine, oxymatrine and resveratrol on HERG channel expression]., PMID:17518040
Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits., PMID:17363390
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits., PMID:16127690
Gating and assembly of heteromeric hERG1a/1b channels underlying I(Kr) in the heart., PMID:16050259
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling., PMID:15800067
Cardiac IKr channels minimally comprise hERG 1a and 1b subunits., PMID:15304481
Expression and role of the ether-à-go-go-related (MERG1A) potassium-channel protein during preimplantation mouse development., PMID:14668215
Spinal circuits formation: a study of developmentally regulated markers in organotypic cultures of embryonic mouse spinal cord., PMID:14614905
A HERG current sustains a cardiac-type action potential in neuroblastoma S cells., PMID:12593854
ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death?, PMID:12490549
Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene., PMID:12270925
The functional properties of the human ether-à-go-go-like (HELK2) K+ channel., PMID:12193184
Functional and molecular identification of ERG channels in murine portal vein myocytes., PMID:12176743
Protein kinase A-mediated phosphorylation of HERG potassium channels in a human cell line., PMID:12133532
Regulation of an ERG K+ current by Src tyrosine kinase., PMID:11834728
HERG K(+) channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate., PMID:11739282
HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium., PMID:11104572
HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1., PMID:11080495
Expression of distinct ERG proteins in rat, mouse, and human heart. Relation to functional I(Kr) channels., PMID:10681594
For research use only. Not for human or drug use.
