Catalog No.
PHF96501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human TOP2B (Ser50-Asn336).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
DNA topoisomerase 2-beta, TOP2B, DNA topoisomerase II, beta isozyme
Purification
Purified by antigen affinity column.
Accession
Q02880
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma., PMID:34753908
Etoposide and topoisomerase II inhibition for aggressive prostate cancer: Data from a translational study., PMID:33091733
Novel localizations and interactions of intercellular bridge proteins revealed by proteomic profiling†., PMID:31995159
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations., PMID:31110352
Trastuzumab-mediated cardiotoxicity: current understanding, challenges, and frontiers., PMID:30215054
Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes., PMID:28203736
Overexpression of Lewis(y) antigen protects ovarian cancer RMG-1 cells from carboplatin-induced apoptosis by the upregulation of Topo-I and Topo-II β., PMID:21542140
Targeting PKC delta-mediated topoisomerase II beta overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line., PMID:20200558
Differential immunohistochemical staining for DNA topoisomerase II alpha and beta in human tissues and for DNA topoisomerase II beta in non-Hodgkin's lymphomas., PMID:9071722
Is DNA topoisomerase II beta a nucleolar protein?, PMID:8913868
Topoisomerase II activities in AML and their correlation with cellular sensitivity to anthracyclines and epipodophyllotoxines., PMID:8683999
For research use only. Not for human or drug use.
