Anti-Human RBX1 Polyclonal Antibody

Catalog No.

PHF54701

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human RBX1 (Ala2-Arg46).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

RING finger protein 75, RNF75, E3 ubiquitin-protein transferase RBX1, N-terminally processed, RBX1, E3 ubiquitin-protein ligase RBX1, Rbx1, ROC1, E3 ubiquitin-protein transferase RBX1, Protein ZYP, RING-box protein 1, Regulator of cullins 1

Purification

Purified by antigen affinity column.

Accession

P62877

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Gene dosage changes in KCTD13 result in penile and testicular anomalies via diminished androgen receptor function., PMID:36196997

A20 and RBX1 Regulate Brentuximab Vedotin Sensitivity in Hodgkin Lymphoma Models., PMID:32299816

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II., PMID:30349055

Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex., PMID:27706223

Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway., PMID:26742010

CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere., PMID:25727006

Knockdown of regulator of cullins-1 (ROC1) expression induces bladder cancer cell cycle arrest at the G2 phase and senescence., PMID:23667514

Endoplasmic reticulum stress induces a caspase-dependent N-terminal cleavage of RBX1 protein in B cells., PMID:22822056

Role of ROC1 protein in the control of cyclin D1 protein expression in skin melanomas., PMID:21300445

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress., PMID:21205095

Hsp90 interaction with INrf2(Keap1) mediates stress-induced Nrf2 activation., PMID:20864537

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation., PMID:20566845

ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2-M arrest, apoptosis, and senescence., PMID:19509229

FBXO25-associated nuclear domains: a novel subnuclear structure., PMID:18287534

Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases., PMID:18203720

Ubiquitination-mediated regulation of biosynthesis of the adhesion receptor SHPS-1 in response to endoplasmic reticulum stress., PMID:14701835

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Anti-Human RBX1 Polyclonal Antibody.pdf