Buy Anti-Human CDH6/Cadherin-6 Polyclonal Antibody

Catalog No.

PHF11801

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CDH6/Cadherin-6 (Asn58-Asp260).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

K-cadherin, CDH6, Cadherin-6, Kidney cadherin

Purification

Purified by antigen affinity column.

Accession

P55285

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Western Blot

Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with CDH6/Cadherin-6 antibody (PHF11801) at 1 μg/ml.

Lane 1: Recombinant protein

Second Ab: Goat Anti-Rabbit IgG H&L Polyclonal antibody, HRP (PTB96431) at 0.1 μg/mL.

Predict MW: 25 kDa
Observed MW: 25 kDa

Antibody-drug conjugates as targeted therapy for treating gynecologic cancers: update 2025., PMID:39480912

PAX8 expression in cancerous and non-neoplastic tissue: a tissue microarray study on more than 17,000 tumors from 149 different tumor entities., PMID:39105782

Neurotensin modulates ovarian vascular permeability via adherens junctions., PMID:38581236

Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models., PMID:38205802

A Phase 1 Study of a CDH6-Targeting Antibody-Drug Conjugate in Patients with Advanced Solid Tumors with Evaluation of Inflammatory and Neurological Adverse Events., PMID:34515215

CDH6-activated αIIbβ3 crosstalks with α2β1 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers., PMID:33715292

Murine cadherin-6 mediates thrombosis in vivo in a platelet-independent manner., PMID:33537536

Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness., PMID:33060832

Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma., PMID:31737572

Beyond N-Cadherin, Relevance of Cadherins 5, 6 and 17 in Cancer Progression and Metastasis., PMID:31324051

RGD cadherins and α2β1 integrin in cancer metastasis: A dangerous liaison., PMID:29673969

Utilizing panels of patient derived xenografts to aid the development of antibody drug conjugates., PMID:29404392

Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers., PMID:28526733

Cadherin 6 has a functional role in platelet aggregation and thrombus formation., PMID:22539596

Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats., PMID:14680511

Cadherin-11 modulates the terminal differentiation and fusion of human trophoblastic cells in vitro., PMID:12710956

Complementary expression and regulation of cadherins 6 and 11 during specific steps of motoneuron differentiation., PMID:12139922

Dynamic testicular adhesion junctions are immunologically unique. II. Localization of classic cadherins in rat testis., PMID:11906918

Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma., PMID:10940709

Differential regulation of endogenous cadherin expression in Madin-Darby canine kidney cells by cell-cell adhesion and activation of beta -catenin signaling., PMID:10747916

Differential expression and function of cadherin-6 during renal epithelium development., PMID:9449663

Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma., PMID:9205085

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Anti-Human CDH6/Cadherin-6 Polyclonal Antibody