Anti-HK2 Polyclonal Antibody

Catalog No.

PHE94901

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human HK2 (Trp619-Arg917).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

HK II, Hexokinase type II, Hexokinase-2, Hexokinase-B, HK2, Muscle form hexokinase

Purification

Purified by antigen affinity column.

Accession

P52789

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation., PMID:40382627

High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer., PMID:40139125

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury., PMID:40007559

Development of an enhanced anti-pan-N-formylmethionine-specific antibody., PMID:39973362

Induction of interleukin 21 receptor expression via enhanced intracellular metabolism in B cells and its relevance to the disease activity in systemic lupus erythematosus., PMID:39740932

Antisense oligonucleotides-based approaches for the treatment of multiple myeloma., PMID:39732226

ATF4 promotes glutaminolysis and glycolysis in colorectal cancer by transcriptionally inducing SLC1A5., PMID:39696988

GS-4997 halts the progression of tubulointerstitial injury in lupus nephritis., PMID:39680018

PI3K-dependent reprogramming of hexokinase isoforms controls glucose metabolism and functional responses of B lymphocytes., PMID:39635128

MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury., PMID:39563422

Immune Checkpoint VISTA Negatively Regulates Microglia Glycolysis and Activation via TRIM28-Mediated Ubiquitination of HK2 in Sepsis-Associated Encephalopathy., PMID:39455538

Serum HMGB-1 released by ferroptosis and necroptosis as a novel potential biomarker for systemic lupus erythematosus., PMID:39128419

Serum autoantibodies against hexokinase 1 manifest secondary to diabetic macular edema onset., PMID:38821414

Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head., PMID:38802413

T-Cell redirecting bispecific antibodies: a review of a novel class of immuno-oncology for advanced prostate cancer., PMID:38801069

A Phase 0 Study to Assess the Biodistribution and Pharmacokinetics of a Radiolabeled Antibody Targeting Human Kallikrein 2 in Participants with Metastatic Castration-Resistant Prostate Cancer., PMID:38782459

Lectin-nanoparticle concept for free PSA glycovariant providing superior cancer specificity., PMID:38677453

Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model., PMID:38637347

Secreted frizzled-related protein 5 protects against renal fibrosis by inhibiting Wnt/β-catenin pathway., PMID:38584843

Short-chain fatty acids ameliorate experimental anti-glomerular basement membrane disease., PMID:38218211

Site-Specific Identification of Protein S-Acylation by IodoTMT0 Labeling and Immobilized Anti-TMT Antibody Resin Enrichment., PMID:38157263

Allosteric Neutralization by Human H7N9 Antibodies., PMID:37986867

Periostin deficiency attenuates kidney fibrosis in diabetic nephropathy by improving pancreatic β-cell dysfunction and reducing kidney EMT., PMID:37845302

3, 3'-diindolylmethane, a natural aryl hydrocarbon receptor agonist, alleviates ulcerative colitis by enhancing "glycolysis-lactate-STAT3″ and TIP60 signals-mediated Treg differentiation., PMID:37793204

Signaling pathways upregulating glutathione‑specific γ‑glutamylcyclotransferase 1 by 3‑(5'‑hydroxymethyl‑2'‑furyl)‑1‑benzylindazole., PMID:37772365

Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor., PMID:37715611

Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis., PMID:37545739

Application of spatial transcriptomics analysis using the Visium system for the mouse nasal cavity after intranasal vaccination., PMID:37545501

Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via inhibition of MX1 transcription., PMID:37506140

Preclinical Development in Radiopharmaceutical Therapy for Prostate Cancer., PMID:37468417

Glycolytic enzyme HK2 promotes PD-L1 expression and breast cancer cell immune evasion., PMID:37377974

Gastric cancer mesenchymal stem cells via the CXCR2/HK2/PD-L1 pathway mediate immunosuppression., PMID:37300724

Aspirin induces immunogenic cell death and enhances cancer immunotherapy in colorectal cancer., PMID:37290325

IL-17C neutralization protects the kidney against acute injury and chronic injury., PMID:37263138

L1CAM promotes vasculogenic mimicry formation by miR-143-3p-induced expression of hexokinase 2 in glioma., PMID:36708044

Targeted protein degradation by Trim-Away using cell resealing coupled with microscopic image-based quantitative analysis., PMID:36601537

Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway., PMID:36330072

Targeted Metabolomics Study of Human Plasma Revealed Activation of the Cytochrome P450 Epoxygenase/Epoxide Hydrolase Axis in Patients with IgA Nephropathy., PMID:36301320

Molecular Pathogenesis of Colorectal Cancer: Impact of Oncogenic Targets Regulated by Tumor Suppressive miR-139-3p., PMID:36232922

Inhibition of lysyl oxidase‑like 2 ameliorates folic acid‑induced renal tubulointerstitial fibrosis., PMID:36168418

Obesity accelerates immune evasion of non-small cell lung carcinoma via TFEB-dependent upregulation of Siglec-15 and glycolytic reprogramming., PMID:36150633

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα., PMID:36007522

A non-metabolic function of hexokinase 2 in small cell lung cancer: promotes cancer cell stemness by increasing USP11-mediated CD133 stability., PMID:35975322

Double-Negative T Cells Attenuate Cisplatin-Induced Acute Kidney Injury via Upregulating IL-10/AT2R Axis., PMID:35941899

High sodium reduced the expression of PTH1R and Klotho by inhibiting 1,25(OH)2D3 synthesis in cultured proximal tubule epithelial cells., PMID:35928745

Iguratimod Restrains Circulating Follicular Helper T Cell Function by Inhibiting Glucose Metabolism via Hif1α-HK2 Axis in Rheumatoid Arthritis., PMID:35720293

Circulating and renal fibrocytes are associated with interstitial fibrosis in lupus nephritis., PMID:35703942

Ischemic Preconditioning Alleviates Mouse Renal Ischemia/Reperfusion Injury by Enhancing Autophagy Activity of Proximal Tubular Cells., PMID:35702707

Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer., PMID:35659359

Mesenchymal Stromal Cells Inhibit Aerobic Glycolysis in Activated T Cells by Negatively Regulating Hexokinase II Activity Through PD-1/PD-L1 Interaction., PMID:35348117

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