Catalog No.
PHB65401
Species reactivity
Human, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SLC34A2/NaPi2b (Ser251-Asp361).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:200, WB: 1:500-1:4000
Target
Sodium/phosphate cotransporter 2B, Na(+)-dependent phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, Sodium-dependent phosphate transport protein 2B, NaPi3b, NaPi-2b, SLC34A2, Solute carrier family 34 member 2, Sodium-phosphate transport protein 2B
Concentration
0.45 mg/ml
Purification
Purified by antigen affinity column.
Accession
O95436
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
T330M Substitution in the Sodium-Dependent Phosphate Transporter NaPi2b Abolishes the Efficacy of Monoclonal Antibodies Against MX35 Epitope., PMID:40265411
Single-cell RNA sequencing reveals surface markers of primordial germ cells in chicken and zebra finch., PMID:39325237
Toward a Topology-Based Therapeutic Design of Membrane Proteins: Validation of NaPi2b Topology in Live Ovarian Cancer Cells., PMID:35911971
Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2., PMID:35777358
NaPi2b expression in a large surgical Non-Small Cell Lung Cancer (NSCLC) cohort., PMID:34953676
Sodium-dependent phosphate transporter NaPi2b as a potential predictive marker for targeted therapy of ovarian cancer., PMID:34504954
Evaluation of the Prognostic Value of Solute Carrier Family 34 Member 2 "SLC34A2" in Papillary Thyroid Carcinoma: An Immunohistochemical Study., PMID:34336552
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b., PMID:33722858
Identification of Potential BRAF Inhibitor Joint Therapy Targets in PTC based on WGCAN and DCGA., PMID:33613767
Evidence of an intestinal phosphate transporter alternative to type IIb sodium-dependent phosphate transporter in rats with chronic kidney disease., PMID:32879980
Phase Ia Study of Anti-NaPi2b Antibody-Drug Conjugate Lifastuzumab Vedotin DNIB0600A in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer., PMID:31540980
Antibody-drug conjugates in gynecologic malignancies., PMID:30929824
Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions., PMID:30053332
High expression of SLC34A2 is a favorable prognostic marker in lung adenocarcinoma patients., PMID:28720066
Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b., PMID:28464843
The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor., PMID:27575453
Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers., PMID:26156394
Binding Affinity, Specificity and Comparative Biodistribution of the Parental Murine Monoclonal Antibody MX35 (Anti-NaPi2b) and Its Humanized Version Rebmab200., PMID:25970341
Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer., PMID:25688157
The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling., PMID:25169055
Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer., PMID:23936189
Visualization of phosphatidylcholine (16:0/16:0) in type II alveolar epithelial cells in the human lung using imaging mass spectrometry., PMID:23692419
Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion., PMID:22661537
In silico analysis and immunohistochemical characterization of NaPi2b protein expression in ovarian carcinoma with monoclonal antibody Mx35., PMID:22553815
Immunohistochemical analysis of NaPi2b protein (MX35 antigen) expression and subcellular localization in human normal and cancer tissues., PMID:21956469
Generation of monoclonal antibodies against tumor-associated antigen MX35/sodium-dependent phosphate transporter NaPi2b., PMID:21466284
Development of monoclonal antibodies specific for the human sodium-dependent phosphate co-transporter NaPi2b., PMID:18724815
Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas., PMID:18251464
Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine., PMID:15701624
Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine., PMID:15701623
Identification and localization of sodium-phosphate cotransporters in hepatocytes and cholangiocytes of rat liver., PMID:15564340
Characterization of a type IIb sodium-phosphate cotransporter from zebrafish (Danio rerio) kidney., PMID:12488247
Glucocorticoid regulation and glycosylation of mouse intestinal type IIb Na-P(i) cotransporter during ontogeny., PMID:12121891
Expression of type II Na-P(i) cotransporter in alveolar type II cells., PMID:10564169
For research use only. Not for human or drug use.
