Catalog No.
PHB27401
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human FCN3 (Glu34-Met297).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
Hakata antigen, HAKA1, FCN3, Collagen/fibrinogen domain-containing lectin 3 p35, FCNH, Ficolin-3, Collagen/fibrinogen domain-containing protein 3
Purification
Purified by antigen affinity column.
Accession
O75636
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Ficolin-3 Activates Complement and Triggers Necroptosis in Cholangiocarcinoma Cells via the RIPK1/RIPK3/MLKL Signaling Pathway., PMID:40407231
Ficolin-3 induces apoptosis and suppresses malignant property of hepatocellular carcinoma cells via the complement pathway., PMID:39357793
A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile., PMID:38219652
Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry., PMID:36638888
Mycobacterium tuberculosis Affects Protein and Lipid Content of Circulating Exosomes in Infected Patients Depending on Tuberculosis Disease State., PMID:35453532
Anti-Ficolin-2 and Anti-Ficolin-3 Autoantibody Detection by ELISA., PMID:33847937
The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury., PMID:33221483
Ficolin-3 Deficiency Is Associated with Disease and an Increased Risk of Systemic Lupus Erythematosus., PMID:31044336
Lectin pathway factors in patients suffering from juvenile idiopathic arthritis., PMID:28405017
Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus., PMID:27631981
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis., PMID:27183610
Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus., PMID:26154564
Studies of the binding of ficolin-2 and ficolin-3 from the complement lectin pathway to Leptospira biflexa, Pasteurella pneumotropica and Diarrheagenic Escherichia coli., PMID:26074063
A novel IgM-H-ficolin complement pathway to attack allogenic cancer cells in vitro., PMID:25592840
Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis., PMID:25251245
High ficolin-3 level at the time of transplantation is an independent risk factor for graft loss in kidney transplant recipients., PMID:25222012
Lack of association of serum mannose/mannan binding lectin or ficolins with complement activation in patients with antiphospholipid antibodies., PMID:25083730
The lectin pathway of the complement system is downregulated in Crohn's disease patients who respond to anti-TNF-α therapy., PMID:24291022
A novel assay to quantitate MASP-2/ficolin-3 complexes in serum., PMID:23142462
Enhanced expression and fucosylation of ficolin3 in plasma of RA patients., PMID:23107985
Increased titers of anti-Saccharomyces cerevisiae antibodies in Crohn's disease patients with reduced H-ficolin levels but normal MASP-2 activity., PMID:22445443
Functional analysis of Ficolin-3 mediated complement activation., PMID:21085669
Serum concentration and interaction properties of MBL/ficolin associated protein-1., PMID:21035894
MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation., PMID:19939495
Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state., PMID:18261799
Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis., PMID:18032536
[Clinical aspects of the complement system]., PMID:16913667
Selecting the right fluorophores and flow cytometer for fluorescence resonance energy transfer measurements., PMID:15825180
Activation of the lectin complement pathway by H-ficolin (Hakata antigen)., PMID:11907111
Detection of serum thermolabile beta-2 macroglycoprotein (Hakata antigen) by enzyme-linked immunosorbent assay using polysaccharide produced by Aerococcus viridans., PMID:11238239
Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile., PMID:10330454
A thermolabile beta 2-macroglycoprotein (TMG) and the antibody against TMG in patients with systemic lupus erythematosus., PMID:9293379
Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus., PMID:1859827
For research use only. Not for human or drug use.
