Catalog No.
VVV00505
Species reactivity
Middle East respiratory syndrome-related coronavirus (MERS-CoV)
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Spike glycoprotein, S glycoprotein, Spike protein S2, S, 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
1.6C7
Anti-S2 antibodies responsible for the SARS-CoV-2 infection-induced serological cross-reactivity against MERS-CoV and MERS-related coronaviruses., PMID:40226608
Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo., PMID:39621673
The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2., PMID:39093891
Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans., PMID:39058596
Mapping immunodominant sites on the MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans., PMID:38617298
Low-sugar universal mRNA vaccine against coronavirus variants with deletion of glycosites in the S2 or stem of SARS-CoV-2 spike messenger RNA (mRNA)., PMID:38011546
Repurposing Navitoclax to block SARS-CoV-2 fusion and entry by targeting heptapeptide repeat sequence 1 in S2 protein., PMID:37804480
An engineered recombinant protein containing three structural domains in SARS-CoV-2 S2 protein has potential to act as a pan-human coronavirus entry inhibitor or vaccine antigen., PMID:37534910
Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses., PMID:36942851
Two formulations of coronavirus disease-19 recombinant subunit vaccine candidate made up of S1 fragment protein P1, S2 fragment protein P2, and nucleocapsid protein elicit strong immunogenicity in mice., PMID:36444622
Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody., PMID:35862475
Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability., PMID:35841885
Binding and neutralizing abilities of antibodies towards SARS-CoV-2 S2 domain., PMID:35417303
Cross-reactive antibodies after SARS-CoV-2 infection and vaccination., PMID:34812143
Stabilized coronavirus spike stem elicits a broadly protective antibody., PMID:34710354
Mapping SARS-CoV-2 Antibody Epitopes in COVID-19 Patients with a Multi-Coronavirus Protein Microarray., PMID:34704808
Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates., PMID:33741598
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies., PMID:33731724
The Potential of Developing Pan-Coronaviral Antibodies to Spike Peptides in Convalescent COVID-19 Patients., PMID:33677719
Bioinformatics prediction of B and T cell epitopes within the spike and nucleocapsid proteins of SARS-CoV2., PMID:33486372
Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2., PMID:32700671
Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection., PMID:31801868
Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections., PMID:29093093
Evaluation of candidate vaccine approaches for MERS-CoV., PMID:26218507
Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation., PMID:24098509
For research use only. Not for human or drug use.
