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Anti-Human DLL3 Antibody (SAA1488)

Catalog #:   FHK06420 Specific References (49) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA, FCM, IHC
Accession: Q9NYJ7
Overview

Catalog No.

FHK06420

Species reactivity

Human, Mouse, Rat

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Conjugation

Unconjugated

Target

Drosophila Delta homolog 3, Delta3, Delta-like protein 3, DLL3

Concentration

1.67 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NYJ7

Applications

ELISA, FCM, IHC

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1488

Data Image
  • Bioactivity
    Detects Human DLL3 in indirect ELISAs.
  • WESTERN BLOT
    Various lysates were subjected to SDS PAGE followed by western blot with DLL3 antibody (FHK06420) at 1µg/ml.

    Lane 1: Human transfected HEK293 cell lysate
    Lane 2: Non-transfected HEK293 cell lysate

    Second Ab: Goat Anti-Mouse IgG H&L Polyclonal antibody, HRP (PMB96431) at 0.1 μg/mL.

    Predict MW: 52 kDa
References

The next generation of immunotherapies for lung cancers., PMID:40528044

T-Cell Engager Therapy in Prostate Cancer: Molecular Insights into a New Frontier in Immunotherapy., PMID:40507301

Harnessing delta-like ligand 3: bridging biomarker discovery to next-generation immunotherapies in refractory small cell lung cancer., PMID:40496850

Treatment of small cell lung cancer; advances and future prospects., PMID:40446464

Taking a Bite Out of Small Cell Lung Cancer By Leveraging Precision-Directed Delta-Like Ligand-3 Therapies., PMID:40440602

FOXA2 promotes metastatic competence in small cell lung cancer., PMID:40419484

Targeting DLL3: Innovative Strategies for Tumor Treatment., PMID:40284515

Real-World Outcomes of Tarlatamab in Small Cell Lung Cancer, Including Patients With Untreated Brain Metastases., PMID:40280845

Population Pharmacokinetics of Tarlatamab, a Half-Life Extended DLL3-Directed Bispecific T-Cell Engager in Patients with Previously Treated Small Cell Lung Cancer., PMID:40261494

Antibody-Based Therapeutics in Small Cell Lung Cancer: A Narrative Review., PMID:40260055

Comparison of two immunotoxins against DLL3 receptor; as an inhibitor for small cell lung cancer., PMID:40177519

Targeting the tumour cell surface in advanced prostate cancer., PMID:40169837

Infectious Complications in Patients Treated with T-cell Engagers as Cancer Immunotherapies, A Descriptive Study from the REISAMIC Registry., PMID:40165410

Advances in adoptive cell therapies in small cell lung cancer., PMID:40160238

[New perspectives in the management of small cell bronchial cancer]., PMID:40155069

Current and future perspectives in extensive-stage small-cell lung cancer., PMID:40093978

Advancement Opportunities and Endeavor of Innovative Targeted Therapies for Small Cell Lung Cancer., PMID:39897044

Practical management of adverse events in patients receiving tarlatamab, a delta-like ligand 3-targeted bispecific T-cell engager immunotherapy, for previously treated small cell lung cancer., PMID:39876075

DLL3 draws two antibody-drug conjugate deals., PMID:39806012

New developments in immunotherapy for SCLC., PMID:39762075

10 years of BiTE immunotherapy: an overview with a focus on pancreatic cancer., PMID:39759138

Assessment of targets of antibody drug conjugates in SCLC., PMID:39748112

Advances in DLL3-targeted therapies for small cell lung cancer: challenges, opportunities, and future directions., PMID:39703856

The Era of Antibody Drug Conjugates in Lung Cancer: Trick or Threat?, PMID:39608345

Pharmacokinetics of Tarlatamab, a Delta-Like Ligand-3 (DLL3) Targeted Half-Life Extended Bispecific T-Cell Engager (BiTE®) Immunotherapy in Adult Patients with Previously Treated Small-Cell Lung Cancer: Results from DeLLphi-300, a Phase I Multiple-Dose-Escalation Study., PMID:39589690

Relationship between the expressions of DLL3, ASC1, TTF-1 and Ki-67: First steps of precision medicine at SCLC., PMID:39392394

DLL3 as a potential diagnostic and therapeutic target in neuroendocrine neoplasms: A narrative review., PMID:39326646

Developmental Therapeutics in Metastatic Prostate Cancer: New Targets and New Strategies., PMID:39272956

Immunotherapy for small cell lung cancer: the current state and future trajectories., PMID:39152301

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models., PMID:39143619

Antibody-drug conjugates treatment of small cell lung cancer: advances in clinical research., PMID:39090431

Immunotherapy in Neuroendocrine Neoplasms: A Diamond to Cut., PMID:39061170

Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen-targeted therapies., PMID:38968122

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients., PMID:38956984

Imaging with [89Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumours of the lung and prostate: a phase 1/2, first-in-human trial., PMID:38950555

FZ-AD005, a Novel DLL3-Targeted Antibody-Drug Conjugate with Topoisomerase I Inhibitor, Shows Potent Antitumor Activity in Preclinical Models., PMID:38940283

FDA approves first DLL3 × CD3 bispecific T-cell engager for lung cancer., PMID:38789515

Expression of Potential Antibody-Drug Conjugate Targets in Cervical Cancer., PMID:38730739

DLL3-guided therapies in small-cell lung cancer: from antibody-drug conjugate to precision immunotherapy and radioimmunotherapy., PMID:38730427

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies., PMID:38645034

Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer., PMID:38558120

Expression patterns and clinical implications of PDL1 and DLL3 biomarkers in small cell lung cancer retrospectively studied: Insights for therapeutic strategies and survival prediction., PMID:38468968

First-in-human imaging with [89Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumors of the lung and prostate., PMID:38260492

Second-Line Treatment Options for Small-Cell Lung Cancer: A Light at the End of the Tunnel., PMID:38254746

Unlocking New Horizons in Small-Cell Lung Cancer Treatment: The Onset of Antibody-Drug Conjugates., PMID:38001628

Correction: Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer., PMID:37923915

Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer., PMID:37731022

Small Cell Lung Cancer: Emerging Targets and Strategies for Precision Therapy., PMID:37627044

Preclinical Development in Radiopharmaceutical Therapy for Prostate Cancer., PMID:37468417

Datasheet
$ 225
Product specifications
50 μg 225 100 μg 372

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For research use only. Not for human or drug use.

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Anti-Human DLL3 Antibody (SAA1488) [FHK06420]
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