Catalog No.
VHN07301
Species reactivity
Human, Mouse, Monkey
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Roundabout homolog 2, ROBO2, KIAA1568
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9HCK4
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
93H2
Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells., PMID:39565875
Downregulation of Roundabout guidance receptor 2 suppresses hepatocellular carcinoma progression by interacting with Y-box binding protein 1., PMID:38297025
A novel immune-related model to predict prognosis and responsiveness to checkpoint and angiogenesis blockade therapy in advanced renal cancer., PMID:36998443
Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program., PMID:34450036
A Phase 1 first-in-human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF-06730512 in healthy participants., PMID:34369667
Runs of Homozygosity in Modern Chicken Revealed by Sequence Data., PMID:33077478
Development of a Cell-Based Assay for the Detection of Neutralizing Antibodies to PF-06730512 Using Homogenous Time-Resolved Fluorescence., PMID:32166588
Methyl-CpG Binding Protein 2 (Mecp2) Regulates Sensory Function Through Sema5b and Robo2., PMID:26733807
Activation of Slit2-Robo1 signaling promotes liver fibrosis., PMID:26264936
srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1., PMID:25149377
An association between genetic variation in the roundabout, axon guidance receptor, homolog 2 gene and immunity traits in chickens., PMID:24570420
Genome-wide association study of antibody response to Newcastle disease virus in chicken., PMID:23663563
Roundabout receptors are critical for foregut separation from the body wall., PMID:23328398
Developmental guidance of embryonic corneal innervation: roles of Semaphorin3A and Slit2., PMID:20471970
Functional diversity of Robo receptor immunoglobulin domains promotes distinct axon guidance decisions., PMID:20206526
Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons., PMID:15737744
Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding., PMID:15207848
Dynamic expression patterns of Robo (Robo1 and Robo2) in the developing murine central nervous system., PMID:14689480
Robo1 and Robo2 are homophilic binding molecules that promote axonal growth., PMID:12504588
For research use only. Not for human or drug use.
