Stromal Hedgehog Signaling Is Associated with Favorable Outcomes in Pancreatic Cancer., PMID:40508010
Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival., PMID:40461501
Combination of encorafenib and binimetinib followed by ipilimumab and nivolumab versus ipilimumab and nivolumab in patients with advanced melanoma with BRAFV600E or BRAFV600K mutations (EBIN): an international, open-label, randomised, controlled, phase 2 study., PMID:40449497
Hedgehog inhibitors exert anti-proliferation effects and synergistically interact with trastuzumab in HER2-positive gastric cancer models., PMID:40426308
Extensive T-Cell Profiling Following SARS-CoV-2 mRNA Vaccination in Multiple Sclerosis Patients Treated with DMTs., PMID:40137720
Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8+ T cells., PMID:40081940
Odronextamab monotherapy in R/R DLBCL after progression with CAR T-cell therapy: primary analysis of the ELM-1 study., PMID:39786390
Efficacy, Safety, and Immunogenicity of the MATISSE (Maternal Immunization Study for Safety and Efficacy) Maternal Respiratory Syncytial Virus Prefusion F Protein Vaccine Trial., PMID:39746212
GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade., PMID:39138140
Reversion of chronic to episodic migraine in working age and botulinum toxin-resistant patients treated with fremanezumab: A real-life study., PMID:39034358
Association of the combined parameters including the frequency of primary cilia, PD-L1, Smoothened protein, membranous β-catenin and cytoplasmic β-catenin expression with the outcome of patients with clear cell renal cell carcinoma., PMID:38420990
Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up., PMID:37595283
Expression Pattern of Sonic Hedgehog, Patched and Smoothened in Clear Cell Renal Carcinoma., PMID:37240278
Genetic mutations in HER2-positive breast cancer: possible association with response to trastuzumab therapy., PMID:37202799
The Acute Optic Neuritis Network (ACON): Study protocol of a non-interventional prospective multicenter study on diagnosis and treatment of acute optic neuritis., PMID:36908609
Dasatinib/prednisone induction followed by blinatumomab/dasatinib in Ph+ acute lymphoblastic leukemia., PMID:36322825
Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer., PMID:36007218
Cancer-targeted photoimmunotherapy induces antitumor immunity and can be augmented by anti-PD-1 therapy for durable anticancer responses in an immunologically active murine tumor model., PMID:35776159
Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants., PMID:35731908
Odronextamab, a human CD20×CD3 bispecific antibody in patients with CD20-positive B-cell malignancies (ELM-1): results from the relapsed or refractory non-Hodgkin lymphoma cohort in a single-arm, multicentre, phase 1 trial., PMID:35366963
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial., PMID:35347281
Construction of a target MSNs drugcarrier loaded with siRNAGLI1 and siRNASMO aim at hedgehog signal pathway and the pharmacodynamic study of drug-carriers in the treatment of leukemia stem cells., PMID:35113326
Long-term efficacy of first-line ibrutinib treatment for chronic lymphocytic leukaemia in patients with TP53 aberrations: a pooled analysis from four clinical trials., PMID:34865212
Pilot study of dogs with suppurative and non-suppurative Malassezia otitis: A case series., PMID:34794441
Rationale and design of the 2 by 2 factorial design GnG-trial: a randomized phase-III study to compare two schedules of gemtuzumab ozogamicin as adjunct to intensive induction therapy and to compare double-blinded intensive postremission therapy with or without glasdegib in older patients with newly diagnosed AML., PMID:34732236
Characterization of Smoothened Phosphorylation and Activation., PMID:34562248
The Immunofluorescence-Based Detection of Hedgehog Pathway Components in Primary Cilia of Cultured Cells., PMID:34562245
Predicting the Course of Graves' Orbitopathy Using Serially Measured TSH-Receptor Autoantibodies by Automated Binding Immunoassays and the Functional Bioassay., PMID:34282595
Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment., PMID:33777671
Construction of specific Smo lentivirus and expression of infected pancreatic cancer cells positive for CD24CD44 surface antibody., PMID:33728829
Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2., PMID:33693749
Proteomic Data Analysis for Differential Profiling of the Autoimmune Diseases SLE, RA, SS, and ANCA-Associated Vasculitis., PMID:33356304
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling., PMID:32929279
Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis., PMID:32929154
Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France., PMID:32747185
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration., PMID:32332736
The Development and Characterization of an scFv-Fc Fusion-Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse., PMID:32245884
Site-Directed Antibody Immobilization by Resorc[4]arene-Based Immunosensors., PMID:32240571
Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study., PMID:32067683
Minimal residual disease undetectable by next-generation sequencing predicts improved outcome in CLL after chemoimmunotherapy., PMID:31537528
Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE., PMID:31521953
The impact of complex karyotype on the overall survival of patients with relapsed chronic lymphocytic leukemia treated with idelalisib plus rituximab., PMID:31427720
Tumor Priming by SMO Inhibition Enhances Antibody Delivery and Efficacy in a Pancreatic Ductal Adenocarcinoma Model., PMID:31363010
Study of Hepatic Involvement and Thrombocytopenia in Dengue., PMID:31311214
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity., PMID:31263273
Domain-interface dynamics of CFTR revealed by stabilizing nanobodies., PMID:31201318
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi., PMID:31168089
Efficacy and predictors of response of lenalidomide and rituximab in patients with treatment-naive and relapsed CLL., PMID:31076409
Taurine enhances mouse cochlear neural stem cell transplantation via the cochlear lateral wall for replacement of degenerated spiral ganglion neurons via sonic hedgehog signaling pathway., PMID:31016387
The Hedgehog target Gli1 is not required for bleomycin-induced lung fibrosis., PMID:30982371
For research use only. Not for human or drug use.
