Catalog No.
RHD05601
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
94 kDa glucose-regulated protein, HSP90B1, gp96 homolog, GRP94, Heat shock protein 90 kDa beta member 1, Endoplasmin, TRA1, Tumor rejection antigen 1, GRP-94
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P14625
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1937
Functional epitope mapping of cell surface glucose-regulated protein 94: A combinatorial approach for therapeutic targeting., PMID:39880265
Targeting cell surface glucose-regulated protein 94 in gastric cancer with an anti-GRP94 human monoclonal antibody., PMID:38449302
Transcriptomic Analysis Reveals Sixteen Potential Genes Associated with the Successful Differentiation of Antibody-Secreting Cells through the Utilization of Unfolded Protein Response Mechanisms in Robust Responders to the Influenza Vaccine., PMID:38400120
Single-cell transcriptomic atlas throughout anti-BCMA CAR-T therapy in patients with multiple myeloma., PMID:38035111
MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps., PMID:37852603
HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas., PMID:37750323
Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection., PMID:37434783
An internalizing antibody targeting of cell surface GRP94 effectively suppresses tumor angiogenesis of colorectal cancer., PMID:35658213
Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells., PMID:35123066
Proteomic changes of aqueous humor in proliferative diabetic retinopathy patients treated with different intravitreal anti-VEGF agents., PMID:35032522
Lrp1 is a host entry factor for Rift Valley fever virus., PMID:34559985
Broadly Protective CD8+ T Cell Immunity to Highly Conserved Epitopes Elicited by Heat Shock Protein gp96-Adjuvanted Influenza Monovalent Split Vaccine., PMID:33827939
Cell Surface GRP94 as a Novel Emerging Therapeutic Target for Monoclonal Antibody Cancer Therapy., PMID:33802964
Induction of SARS-CoV-2 Protein S-Specific CD8+ T Cells in the Lungs of gp96-Ig-S Vaccinated Mice., PMID:33584668
gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections., PMID:32295911
Endoplasmic reticulum stress promotes inflammation-mediated proteolytic activity at the ocular surface., PMID:32042069
Glycoprotein 96 polymorphisms are associated with the risk of systemic lupus erythematosus: A case-control study., PMID:30860673
Improving the potency of DNA vaccine encoding HIV-1 Nef antigen using two endogenous adjuvants in mouse model., PMID:29061065
Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cells., PMID:28526855
Immuno-Stimulating Peptide Derived from HMGB1 is More Effective Than the N-Terminal Domain of Gp96 as an Endogenous Adjuvant for Improvement of Protein Vaccines., PMID:28000571
Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold., PMID:27959508
Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity., PMID:27872147
Grp94 in complexes with IgG is a soluble diagnostic marker of gastrointestinal tumors and displays immune-stimulating activity on peripheral blood immune cells., PMID:27662661
Heat-Shock Protein gp96 Enhances T Cell Responses and Protective Potential to Bacillus Calmette-Guérin Vaccine., PMID:27417661
Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination., PMID:27364122
Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold., PMID:27003516
GRP94/gp96 in Cancer: Biology, Structure, Immunology, and Drug Development., PMID:26916005
Autoantibodies to Heat-Shock Protein, HSPA5, and Epitope Spreading: High-Dose Dexamethasone Therapy Rescues Ovarian Function in Experimental Autoimmune Ovarian Insufficiency Mouse Model., PMID:26840828
Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α-synuclein-elicited immune response., PMID:26443817
Chaperone gp96 mediates ER-α36 cell membrane expression., PMID:26396174
Proteomic Investigation on Grp94-IgG Complexes Circulating in Plasma of Type 1 Diabetic Subjects., PMID:26167512
Cell membrane gp96 facilitates HER2 dimerization and serves as a novel target in breast cancer., PMID:25546612
Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers., PMID:25225353
[Expression of anti-gp96 scFv fragment in Pichia pastoris and identification of its biological activity]., PMID:25195249
Reproducibility and efficiency of serum-derived exosome extraction methods., PMID:24956264
Detection of novel auto-antigens in patients with recurrent miscarriage: description of an approach and preliminary findings., PMID:24891284
MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress., PMID:24888588
Heat shock protein 90β stabilizes focal adhesion kinase and enhances cell migration and invasion in breast cancer cells., PMID:24880126
Activation of anti-HBV immune activity by DNA vaccine via electroporation using heat shock proteins as adjuvant., PMID:24660624
Heat shock proteins purified from autologous tumors using antibody-based affinity chromatography., PMID:24619689
Structural insights into complexes of glucose-regulated Protein94 (Grp94) with human immunoglobulin G. relevance for Grp94-IgG complexes that form in vivo in pathological conditions., PMID:24489700
[Palmitate induces apoptosis and endoplasmic reticulum stress in human umbilical cord-derived mesenchymal stem cells]., PMID:24343717
Napyradiomycins CNQ525.510B and A80915C target the Hsp90 paralogue Grp94., PMID:24292715
Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases., PMID:24254084
Cryopreservation of common carp (Cyprinus carpio L.) sperm induces protein phosphorylation in tyrosine and threonine residues., PMID:23602083
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway., PMID:23572575
Isolation and identification of renal cell carcinoma-derived peptides associated with GP96., PMID:23448575
Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus., PMID:23401588
Listeria monocytogenes triggers the cell surface expression of Gp96 protein and interacts with its N terminus to support cellular infection., PMID:23109341
Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis., PMID:22777994
For research use only. Not for human or drug use.
