Catalog No.
RHD54401
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
T-cell activation protein 519, Protein NKG5, TLA519, Lymphokine LAG-2, GNLY, NKG5, Granulysin, LAG2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P22749
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1936
Novel diagnostic biomarker and immune profiling of GPR56+ B cell subsets in systemic lupus erythematosus., PMID:40311320
GNLY+CD8+ T cells bridge premature aging and persistent inflammation in people living with HIV., PMID:40135938
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age., PMID:39881000
Human cancer cells xenografts to assess the efficacy of granulysin-based therapeutics., PMID:39863395
Gene Expression Profiling of the Peritumoral Immune Cell Infiltrate of Penile Squamous Cell Carcinomas., PMID:39596210
T-cell Mediated Rejection Associated Microvascular Inflammation in the Allograft Kidney: RNAseq Analysis Using the Banff Human Organ Transplant Gene Panel., PMID:39033507
Identification of different functions of CD8+ T cell subpopulations by a novel monoclonal antibody., PMID:38922845
Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome., PMID:38471344
Differentially Expressed Genes Involved in Primary Resistance to Immunotherapy in Patients with Advanced-Stage Pulmonary Cancer., PMID:38396726
Novel transcriptomic signatures associated with premature kidney allograft failure., PMID:37660534
Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related disease., PMID:37561593
Autoimmune thyroid disease disrupts immune homeostasis in the endometrium of unexplained infertility women-a single-cell RNA transcriptome study during the implantation window., PMID:37501789
Blocking of programmed cell death-ligand 1 (PD-L1) expressed on endothelial cells promoted the recruitment of CD8+IFN-γ+ T cells in atherosclerosis., PMID:36867228
Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data., PMID:36195867
Immune features of COVID-19 convalescent individuals revealed by a single-cell RNA sequencing., PMID:35453072
The Trifecta Study: Comparing Plasma Levels of Donor-derived Cell-Free DNA with the Molecular Phenotype of Kidney Transplant Biopsies., PMID:35058354
Artificial Neural Networks Predicted the Overall Survival and Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Pancancer Immune-Oncology Panel., PMID:34945004
Chronic Active Antibody-Mediated Rejection Is Associated With the Upregulation of Interstitial But Not Glomerular Transcripts., PMID:34616398
A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients., PMID:34322127
The Role of IL-13, IL-15 and Granulysin in the Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis., PMID:33560872
Granzyme B-expressing γδ-T and NK cells as a predictor of clinical pregnancy failure in patients with unexplained repeated implantation failure., PMID:33540297
γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis., PMID:33432229
Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology., PMID:32859066
The cytotoxic molecule granulysin is capable of inducing either chemotaxis or fugetaxis in dendritic cells depending on maturation: a role for Vδ2+ γδ T cells in the modulation of immune response to tumour?, PMID:32794189
Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma., PMID:32042196
Reverse transcriptase multiplex ligation-dependent probe amplification in endomyocardial biopsies for the diagnosis of cardiac allograft rejection., PMID:31822443
[Mechanisms of Severe Cutaneous Adverse Reactions and a New Treatment Strategy]., PMID:31787645
Activated cytotoxic T cells within zoonotic cutaneous leishmaniasis lesions., PMID:30997749
Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes., PMID:30038217
A Case Report and Literature Review of Scrub Typhus With Acute Abdomen and Septic Shock in a Child-The Role of Leukocytoclastic Vasculitis and Granulysin., PMID:29697421
Randomized, controlled trial of TNF-α antagonist in CTL-mediated severe cutaneous adverse reactions., PMID:29400697
Review: The transcripts associated with organ allograft rejection., PMID:29178397
Review of Toxic Epidermal Necrolysis., PMID:27999358
Evidence for CD16a-Mediated NK Cell Stimulation in Antibody-Mediated Kidney Transplant Rejection., PMID:27906829
Evaluation of serum granulysin as a potential biomarker for nasopharyngeal carcinoma., PMID:26751807
The molecular landscape of antibody-mediated kidney transplant rejection: evidence for NK involvement through CD16a Fc receptors., PMID:25787894
Acquired Idiopathic Generalized Anhidrosis: An Immunohistopathological Investigation of Peri-glands Infiltrated with Immunoreactive Cells., PMID:25519938
The peripheral blood transcriptome reflects variations in immunity traits in swine: towards the identification of biomarkers., PMID:24341289
Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin., PMID:23803412
Granule exocytosis of granulysin and granzyme B as a potential key mechanism in vaccine-induced immunity in cattle against the nematode Ostertagia ostertagi., PMID:23478322
Distinguishing between erythema multiforme major and Stevens-Johnson syndrome/toxic epidermal necrolysis immunopathologically., PMID:22458564
Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event., PMID:21967803
Pretreatment serum level of 15-kDa granulysin might have a prognostic value in patients with diffuse large B cell lymphoma., PMID:21540579
Rapid immunochromatographic test for serum granulysin is useful for the prediction of Stevens-Johnson syndrome and toxic epidermal necrolysis., PMID:21507517
[The purification of recombinated granulysin and the preparation of its monoclonal antibody]., PMID:20734534
Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin., PMID:20660289
GLS/IL-12-modified Mycobacterium smegmatis as a novel anti-tuberculosis immunotherapeutic vaccine., PMID:19861007
Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen., PMID:18588932
Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients., PMID:17038537
Construction of a eukaryotic expression system for granulysin and its protective effect in mice infected with Mycobacterium tuberculosis., PMID:17005788
For research use only. Not for human or drug use.
