Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Antibody / Recombinant Antibody

Anti-Human ORAI1 Antibody (SAA1876)

Catalog #:   RHN04101 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA
Accession: Q96D31
Overview

Catalog No.

RHN04101

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

CRACM1, Protein orai-1, Calcium release-activated calcium channel protein 1, Transmembrane protein 142A, ORAI1, TMEM142A

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q96D31

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1876

Data Image
References

Anoctamin 9 determines Ca2+ signals during activation of T-lymphocytes., PMID:40207216

A Comparison between LTT and CFSE Proliferation Tests in Patients with Inborn Errors of Adaptive Immunity., PMID:40183264

Immunogenetic Studies in Patients With GAD-Positive Stiff-Person Syndrome Reveal Novel Lymphocytic Genes and KLK10-Gene Variants., PMID:39933127

Genomic profiling at a single center cracks the code in inborn errors of immunity., PMID:39873967

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer., PMID:39191092

IL-37 protects against house dust mite-induced airway inflammation and airway epithelial barrier dysfunction via inhibiting store-operated calcium entry., PMID:38941668

STIM1, ORAI1, and KDM2B in circulating tumor cells (CTCs) isolated from prostate cancer patients., PMID:38903530

The ion channel TRPV5 regulates B-cell signaling and activation., PMID:38694510

ORAI Ca2+ Channels in Cancers and Therapeutic Interventions., PMID:38672434

Self-Cleavage of Human Chloride Channel Accessory 2 Causes a Conformational Shift That Depends on Membrane Anchorage and Is Required for Its Regulation of Store-Operated Calcium Entry., PMID:38001916

Methods to Quantify the Dynamic Recycling of Plasma Membrane Channels., PMID:37719078

ORAI1 defect in a patient with disseminated CMV infection and severe hypotonia., PMID:37661687

The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1., PMID:37167218

Excessive neutrophil extracellular trap formation induced by Porphyromonas gingivalis lipopolysaccharide exacerbates inflammatory responses in high glucose microenvironment., PMID:36743304

LncRNA MEG3 inhibits renal fibrinoid necrosis of diabetic nephropathy via the MEG3/miR-21/ORAI1 axis., PMID:36715789

STIM1-Orai1 Interaction Exacerbates LPS-Induced Inflammation and Endoplasmic Reticulum Stress in Bovine Hepatocytes through Store-Operated Calcium Entry., PMID:35627260

Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis., PMID:35444784

Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria., PMID:34764278

CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis., PMID:34745151

Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K+ Channels in T-Lymphocytes., PMID:34639190

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity., PMID:33356720

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation., PMID:33252040

Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation., PMID:32821879

Gardenia jasminoides extract and its constituent, genipin, inhibit activation of CD3/CD28 co-stimulated CD4+ T cells via ORAI1 channel., PMID:32587130

To B, or not to B: Is calcium the answer?, PMID:32563861

BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells., PMID:32294437

Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension., PMID:32075490

STIM1 knock-down decreases the affinity of obinutuzumab for CD20 by altering CD20 localization to Triton-soluble membrane., PMID:32056202

STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia., PMID:31014395

Role of Calcium Signaling in GA101-Induced Cell Death in Malignant Human B Cells., PMID:30832225

[ORAI1 variation induced combined immunodeficiency: a case report and literature review]., PMID:30695890

EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction., PMID:30481768

Spirodela polyrhiza and its Chemical Constituent Vitexin Exert Anti-Allergic Effect via ORAI1 Channel Inhibition., PMID:30149756

Simulation of the Dynamics of Primary Immunodeficiencies in B Cells., PMID:30116248

OMIP-048 MC: Quantification of calcium sensors and channels expression in lymphocyte subsets by mass cytometry., PMID:30080305

ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment., PMID:30003689

Orai1 downregulation impairs lymphocyte function in type 2 diabetes mellitus., PMID:29654766

Ion channelopathies of the immune system., PMID:29635109

Filamin A Modulates Store-Operated Ca2+ Entry by Regulating STIM1 (Stromal Interaction Molecule 1)-Orai1 Association in Human Platelets., PMID:29284605

Inhibitory Effect of Afatinib on Platelet Activation and Apoptosis., PMID:29073606

Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling., PMID:29029788

Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells., PMID:28775294

Beyond Th2, more than ILC2., PMID:28668290

Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells., PMID:28301277

Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies., PMID:28057434

Selaginella uncinata flavonoids ameliorated ovalbumin-induced airway inflammation in a rat model of asthma., PMID:27916586

AMPA Receptors Are Involved in Store-Operated Calcium Entry and Interact with STIM Proteins in Rat Primary Cortical Neurons., PMID:27826230

SOCE proteins, STIM1 and Orai1, are localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos., PMID:27702423

Exercise Affects T-Cell Function by Modifying Intracellular Calcium Homeostasis., PMID:27525377

Visualizing Quantum Dot Labeled ORAI1 Proteins in Intact Cells Via Correlative Light and Electron Microscopy., PMID:27515473

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Anti-Human ORAI1 Antibody (SAA1876) [RHN04101]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only