Catalog No.
RHN03001
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Netrin receptor UNC5B, Protein unc-5 homolog B, Protein unc-5 homolog 2, P53RDL1, UNC5B, p53-regulated receptor for death and life protein 1, UNC5H2, p53RDL1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8IZJ1
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1865
Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-retina barrier integrity., PMID:39693351
The FLRT3-UNC5B checkpoint pathway inhibits T cell-based cancer immunotherapies., PMID:38427724
Pharmacological targeting of netrin-1 inhibits EMT in cancer., PMID:37532929
Analysis of N-glycosylation protein of Kashin-Beck disease chondrocytes derived from induced pluripotent stem cells based on label-free strategies with LC-MS/MS., PMID:37186116
Netrin-1 binding to Unc5B regulates Blood-Retina Barrier integrity., PMID:36711611
GPC3-Unc5 receptor complex structure and role in cell migration., PMID:36240740
Endothelial Unc5B controls blood-brain barrier integrity., PMID:35246514
Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity., PMID:34470826
IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation., PMID:34403503
Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury., PMID:33914819
Polyomavirus Small T Antigen Induces Apoptosis in Mammalian Cells through the UNC5B Pathway in a PP2A-Dependent Manner., PMID:32404521
Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells., PMID:28373074
Netrin-1 and its receptor Unc5b are novel targets for the treatment of inflammatory arthritis., PMID:27502509
Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a., PMID:27509208
Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo., PMID:27430720
Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis., PMID:26452536
[Preparation of a uncoordinated-5 homolog B monoclonal antibody and its effect on melanoma cell migration in vitro]., PMID:26359108
CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development., PMID:25656845
Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation., PMID:25483983
An uncoordinated-5 homolog B receptor monoclonal antibody regulates A375 melanoma cell migration., PMID:25171009
Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s): Tampere Vascular Study (TVS)., PMID:24122613
PKCα is involved in the progression of kidney carcinoma through regulating netrin-1/UNC5B signaling pathway., PMID:23526078
Multifunctional protein APPL2 contributes to survival of human glioma cells., PMID:22989406
The uncoordinated-5 homolog B receptor affects hepatic ischemia reperfusion injury., PMID:22848430
Netrin-1 simultaneously suppresses corneal inflammation and neovascularization., PMID:22323486
Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B., PMID:21238923
Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons., PMID:20882566
SDF-1/CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis., PMID:20181837
Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor., PMID:19328064
Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B., PMID:18719102
For research use only. Not for human or drug use.
