Catalog No.
RHN02501
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Matriptase-2, Transmembrane protease serine 6, TMPRSS6
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q8IU80
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1860
Combination of a TGF-β ligand trap (RAP-GRL) and TMPRSS6-ASO is superior for correcting β-thalassemia., PMID:38659383
A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice., PMID:38241484
Transcriptomic Mapping of Non-Small Cell Lung Cancer K-RAS p.G12C Mutated Tumors: Identification of Surfaceome Targets and Immunologic Correlates., PMID:35178045
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection., PMID:33665641
Ziltivekimab for Treatment of Anemia of Inflammation in Patients on Hemodialysis: Results from a Phase 1/2 Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial., PMID:33272965
Matriptase-2 deficiency protects from obesity by modulating iron homeostasis., PMID:29636509
The role of TMPRSS6 and HFE variants in iron deficiency anemia in celiac disease., PMID:29194702
Proteolytic cleavages in the extracellular domain of receptor tyrosine kinases by membrane-associated serine proteases., PMID:28915606
Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats., PMID:28282554
Systematic evaluation of paediatric cohort with iron refractory iron deficiency anaemia (IRIDA) phenotype reveals multiple TMPRSS6 gene variations., PMID:28169443
Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats., PMID:26845567
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice., PMID:21622652
Immunoassay for human serum hemojuvelin., PMID:20713458
For research use only. Not for human or drug use.
