Catalog No.
RHG81501
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Sodium channel protein type V subunit alpha, SCN5A, Sodium channel protein type 5 subunit alpha, hH1, Voltage-gated sodium channel subunit alpha Nav1.5, Sodium channel protein cardiac muscle subunit alpha
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14524
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1835
NaV1.5 autoantibodies in Brugada syndrome: pathogenetic implications., PMID:39078224
Change of voltage-gated sodium channel repertoire in skeletal muscle of a MuSK myasthenia gravis mouse model., PMID:38650308
In silico drug repurposing in COVID-19: A network-based analysis., PMID:34358753
iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities., PMID:33510259
Lidocaine inhibits the metastatic potential of ovarian cancer by blocking NaV 1.5-mediated EMT and FAK/Paxillin signaling pathway., PMID:33280262
SCN5A gene variants as potential markers of the progression of chronic chagasic cardiac alterations., PMID:33137501
An autoantibody profile detects Brugada syndrome and identifies abnormally expressed myocardial proteins., PMID:32533187
Supramolecular clustering of the cardiac sodium channel Nav1.5 in HEK293F cells, with and without the auxiliary β3-subunit., PMID:31950564
Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies., PMID:29333591
Changes in cardiac Nav1.5 expression, function, and acetylation by pan-histone deacetylase inhibitors., PMID:27638876
Congenital and childhood atrioventricular blocks: pathophysiology and contemporary management., PMID:27351174
Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016., PMID:27294413
Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines., PMID:27160185
Extracellular Matrix-Mediated Maturation of Human Pluripotent Stem Cell-Derived Cardiac Monolayer Structure and Electrophysiological Function., PMID:27069088
Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum., PMID:26459913
CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure., PMID:25815641
Crystal structure and molecular imaging of the Nav channel β3 subunit indicates a trimeric assembly., PMID:24567321
Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats., PMID:23684688
TGF-β1, released by myofibroblasts, differentially regulates transcription and function of sodium and potassium channels in adult rat ventricular myocytes., PMID:23393573
A novel missense mutation, I890T, in the pore region of cardiac sodium channel causes Brugada syndrome., PMID:23308164
Mass spectrometry-based identification of native cardiac Nav1.5 channel α subunit phosphorylation sites., PMID:23092124
Parental electrocardiographic screening identifies a high degree of inheritance for congenital and childhood nonimmune isolated atrioventricular block., PMID:22899775
Reactive oxygen species suppress cardiac NaV1.5 expression through Foxo1., PMID:22400069
TGF-β1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging., PMID:21493874
F 15845, a new blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery., PMID:20735424
Tubulin polymerization modifies cardiac sodium channel expression and gating., PMID:19861310
Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: clinical potential of neonatal Nav1.5 in breast cancer., PMID:19835862
Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties., PMID:19796257
Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel., PMID:18616619
Heterozygous nonsense SCN5A mutation W822X explains a simultaneous sudden infant death syndrome., PMID:18551308
Regulation of caveolar cardiac sodium current by a single Gsalpha histidine residue., PMID:18281377
Localization of Na+ channel isoforms at the atrioventricular junction and atrioventricular node in the rat., PMID:16966585
The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells., PMID:16838113
A novel polyclonal antibody specific for the Na(v)1.5 voltage-gated Na(+) channel 'neonatal' splice form., PMID:16111763
Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis., PMID:16061851
Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes., PMID:15272007
The genetic origin of atrioventricular conduction disturbance in humans., PMID:12956334
Localization of Nav1.5 sodium channel protein in the mouse brain., PMID:12499865
SCN5A is expressed in human jejunal circular smooth muscle cells., PMID:12358675
For research use only. Not for human or drug use.
