Catalog No.
RHE21001
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
TGFR-2, TbetaR-II, TGF-beta type II receptor, TGFBR2, TGF-beta receptor type-2, TGF-beta receptor type II, Transforming growth factor-beta receptor type II
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P37173
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1803
Discovery of a Selective, Novel TGF-βR1 Inhibitor GFH018 for the Treatment of Solid Tumors., PMID:40505138
Emerging Pathogenetic Mechanisms and New Drugs for Anemia in Myelofibrosis and Myelodysplastic Syndromes., PMID:40056069
Cripto-1 acts as a molecular bridge linking nodal to ALK4 via distinct structural domains., PMID:39840816
A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells., PMID:39786928
Impact of Lysine to Methionine Ratios on Antioxidant Capacity and Immune Function in the Rumen of Tibetan Sheep: An RNA-Seq Analysis., PMID:39708312
Exploring the potential of TGFβ as a diagnostic marker and therapeutic target against cancer., PMID:39577704
TGF-β receptor-specific NanoBRET Target Engagement in living cells for high-throughput kinase inhibitor screens., PMID:39542424
Simultaneous detection of myostatin-targeting monoclonal antibodies in dried blood spots and plasma using liquid chromatography-tandem mass spectrometry with field asymmetric ion mobility spectrometry., PMID:39405785
CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β., PMID:39220887
Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model., PMID:39185375
Subclone from CT26 resistant to anti-PD-1 therapy associated with increased expression of genes related to glucocorticoids., PMID:38861853
Bone marrow Tfr2 deletion improves the therapeutic efficacy of the activin-receptor ligand trap RAP-536 in β-thalassemic mice., PMID:38629683
TGF-β1 induces PD-1 expression in macrophages through SMAD3/STAT3 cooperative signaling in chronic inflammation., PMID:38441961
Targeting transforming growth factor beta signaling in metastatic osteosarcoma., PMID:38021074
Hepsin promotes breast tumor growth signaling via the TGFβ-EGFR axis., PMID:37872868
Inducible nitric oxide synthase (iNOS)-activated Cxcr2 signaling in myeloid cells promotes TGFβ-dependent squamous cell carcinoma lung metastasis., PMID:37524225
Circulating neutrophils activated by cancer cells and M2 macrophages promote gastric cancer progression during PD-1 antibody-based immunotherapy., PMID:37333017
Emerging biologics for the treatment of pulmonary arterial hypertension., PMID:37026714
Novel Molecular Therapies and Genetic Landscape in Selected Rare Diseases with Hematologic Manifestations: A Review of the Literature., PMID:36766791
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling., PMID:36717814
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma., PMID:36525138
Monitoring tumour resistance to the BRAF inhibitor combination regimen in colorectal cancer patients via circulating tumour DNA., PMID:36202008
Detection of activin receptor type IIA and IIB-Fc fusion proteins by automated capillary immunoassay., PMID:36200177
Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1., PMID:36066618
Relationship Between Angiotensin II Type 1 Receptor Antibody Positivity and Cytokine Gene Polymorphism in Renal Transplant Patients When Organ Rejection Occurs., PMID:35867016
TGFβ and CIS Inhibition Overcomes NK-cell Suppression to Restore Antitumor Immunity., PMID:35759796
Tacrolimus Up-regulates Expression of TGFβ Receptor Type II via ERK, Providing Protection Against Intestinal Epithelial Injury., PMID:35738634
Tumor in the Crossfire: Inhibiting TGF-β to Enhance Cancer Immunotherapy., PMID:35353346
Inhibition of Integrin αvβ6 Activation of TGF-β Attenuates Tendinopathy., PMID:35166070
Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-β1 and NGF-β Attenuate pKAL-Induced Anticancer Effects via NF-κB p65 Upregulation., PMID:35163520
PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II., PMID:35139382
Optimization strategies for expression of a novel bifunctional anti-PD-L1/TGFBR2-ECD fusion protein., PMID:34560256
Hyper-IgE syndrome, 2021 update., PMID:34419355
Progression of melanoma is suppressed by targeting all transforming growth factor‑β isoforms with an Fc chimeric receptor., PMID:34296292
Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family., PMID:34155118
Bifunctional TGF-β trap/IL-15 protein complex elicits potent NK cell and CD8+ T cell immunity against solid tumors., PMID:34091051
Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival., PMID:34013359
Biological drug and drug delivery-mediated immunotherapy., PMID:33996408
Transcriptomic Profiles of CD47 in Breast Tumors Predict Outcome and Are Associated with Immune Activation., PMID:33917174
Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model., PMID:33707311
Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer., PMID:33688022
Development of luspatercept to treat ineffective erythropoiesis., PMID:33687432
Single nucleotide variants in immune-response genes and the tumor microenvironment composition predict progression of mantle cell lymphoma., PMID:33648463
[The study of interaction of different forms of human recombinant anti-mullerian hormone with a chimeric analogue of the AMH type II]., PMID:33645523
Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells., PMID:33490663
Lactobacillus rhamnosus GG alleviates β-conglycinin-induced allergy by regulating the T cell receptor signaling pathway., PMID:33185639
Inhibition of the activin receptor signaling pathway: A novel intervention against osteosarcoma., PMID:33179858
The predicting role of circulating tumor DNA landscape in gastric cancer patients treated with immune checkpoint inhibitors., PMID:33126883
Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells., PMID:33087933
Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism., PMID:33087490
For research use only. Not for human or drug use.
