Catalog No.
RHG66101
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
BMP type II receptor, BMPR-II, Bone morphogenetic protein receptor type II, Bone morphogenetic protein receptor type-2, BMPR2, PPH1, BMP type-2 receptor, BMPR-2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q13873
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1802
ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice., PMID:39994804
New therapies in pulmonary arterial hypertension: Recent insights., PMID:39991439
B-cells in pulmonary arterial hypertension: friend, foe or bystander?, PMID:38485150
Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice., PMID:39196046
microRNA Expression Profile of Purified Alveolar Epithelial Type II Cells., PMID:36011331
Evolving nonvasodilator treatment options for pulmonary arterial hypertension., PMID:35838352
Autoimmunity Is a Significant Feature of Idiopathic Pulmonary Arterial Hypertension., PMID:35316153
The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH., PMID:34818449
Blockade of the interaction between BMP9 and endoglin on erythroid progenitors promotes erythropoiesis in mice., PMID:34333851
Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family., PMID:34155118
Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival., PMID:34013359
ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders., PMID:33586684
TET-dependent GDF7 hypomethylation impairs aqueous humor outflow and serves as a potential therapeutic target in glaucoma., PMID:33388417
BMP6 Regulates Corneal Epithelial Cell Stratification by Coordinating Their Proliferation and Differentiation and Is Upregulated in Pterygium., PMID:32845956
Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells., PMID:32813135
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop., PMID:32515349
Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension., PMID:32192357
Smad1/5 signal transduction regulates the ameloblastic differentiation of induced pluripotent stem cells., PMID:32022225
GDF11 is not the target of luspatercept., PMID:31395583
Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody., PMID:31186065
Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension., PMID:30636542
Luspatercept for the treatment of anemia in myelodysplastic syndromes and primary myelofibrosis., PMID:30602619
SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2., PMID:29976569
Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15., PMID:29425507
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy., PMID:29109273
Molecular forms of ruminant BMP15 and GDF9 and putative interactions with receptors., PMID:28733348
Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1., PMID:28642261
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5., PMID:28489883
Utilizing BMP-2 muteins for treatment of multiple myeloma., PMID:28489849
Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis., PMID:28133920
The DART Study: Results from the Dose-Escalation and Expansion Cohorts Evaluating the Combination of Dalantercept plus Axitinib in Advanced Renal Cell Carcinoma., PMID:28031424
Transforming growth factor-β plays divergent roles in modulating vascular remodeling, inflammation, and pulmonary fibrosis in a murine model of scleroderma., PMID:27864286
A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck., PMID:27648727
Targeting tumour vasculature by inhibiting activin receptor-like kinase (ALK)1 function., PMID:27528762
Generation of a Bone Organ by Human Adipose-Derived Stromal Cells Through Endochondral Ossification., PMID:27334490
Phase I study of PF-03446962, a fully human monoclonal antibody against activin receptor-like kinase-1, in patients with hepatocellular carcinoma., PMID:27329247
Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma., PMID:27248821
Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice., PMID:27194944
A phase I study of the human anti-activin receptor-like kinase 1 antibody PF-03446962 in Asian patients with advanced solid tumors., PMID:27075560
Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains., PMID:26677222
Bone morphogenetic protein 4 and bone morphogenetic protein receptor expression in the pituitary gland of adult dogs in healthy condition and with ACTH-secreting pituitary adenoma., PMID:26542941
Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors., PMID:26373572
BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension., PMID:25863249
Activin receptor inhibitors--dalantercept., PMID:25708802
Leiomyoma-derived transforming growth factor-β impairs bone morphogenetic protein-2-mediated endometrial receptivity., PMID:25596622
Development of novel activin-targeted therapeutics., PMID:25399825
Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer., PMID:24173543
Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy., PMID:24053899
Noncanonical transforming growth factor β (TGFβ) signaling in cranial neural crest cells causes tongue muscle developmental defects., PMID:23950180
Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development., PMID:23812757
For research use only. Not for human or drug use.
