Anti-Human TSPO Antibody (SAA1799)

Catalog No.

RHD89901

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

PKBS, TSPO, MBR, PBR, BZRP, Translocator protein, Peripheral-type benzodiazepine receptor, Mitochondrial benzodiazepine receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P30536

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1799

Dampening of Microglial Activation With Nasal Foralumab Administration in Moderate Alzheimer's Disease Dementia., PMID:40359013

Microglial Activation Visualized by [18F]-DPA714 PET Is a Potential Marker of Severity and Prognosis for Anti-LGI1 Encephalitis., PMID:40052391

[123I]CLINDE SPECT as a neuroinflammation imaging approach in a rat model of stroke., PMID:38823675

Evaluation of microglia activation related markers following a clinical course of TBS: A non-human primate study., PMID:38753646

Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers., PMID:38585455

Translocator protein expression and localization in human endometrium and endometriosis: A potential target for a noninvasive diagnosis?, PMID:38511230

Microglial Activation Imaging Using 18F-DPA-714 PET/MRI for Detecting Autoimmune Encephalitis., PMID:38441089

Amphiphysin-IgG autoimmune sciatic neuropathy and facial neuropathy related to primary central nervous system lymphoma: A case report., PMID:37556888

PET imaging of TREM1 identifies CNS-infiltrating myeloid cells in a mouse model of multiple sclerosis., PMID:37379371

Early prognosticators of later TSPO-PET-measurable microglial activation in multiple sclerosis., PMID:37216883

Preventative effect of TSPO ligands on mixed antibody-mediated rejection through a Mitochondria-mediated metabolic disorder., PMID:37131248

Mitochondrial TSPO Promotes Hepatocellular Carcinoma Progression through Ferroptosis Inhibition and Immune Evasion., PMID:36994647

Potential of [11C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model., PMID:36559209

Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study., PMID:35303961

The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic., PMID:35181440

Tracking Innate Immune Activation in a Mouse Model of Parkinson's Disease Using TREM1 and TSPO PET Tracers., PMID:35177426

Activation of GABA(A) receptors inhibits T cell proliferation., PMID:34014994

Assessment of 18F-PBR-111 in the Cuprizone Mouse Model of Multiple Sclerosis., PMID:33925560

Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue., PMID:33846725

TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy., PMID:33757118

The Neuroimmunology of Chronic Pain: From Rodents to Humans., PMID:33239404

Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer's-like mice., PMID:31931873

Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats., PMID:31796042

Systemic knockout of Tspo in mice does not affect retinal morphology, function and susceptibility to degeneration., PMID:31562844

Cell-autonomous, paracrine and neuroendocrine feedback regulation of autophagy by DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein): the obesity factor., PMID:31470770

Natalizumab treatment reduces microglial activation in the white matter of the MS brain., PMID:31355310

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation., PMID:31073768

Translocator protein localises to CD11b+ macrophages in atherosclerosis., PMID:30913515

In vivo imaging of activated macrophages by 18F-FEDAC, a TSPO targeting PET ligand, in the use of biologic disease-modifying anti-rheumatic drugs (bDMARDs)., PMID:30343885

Novel potential pyrazolopyrimidine based translocator protein ligands for the evaluation of neuroinflammation with PET., PMID:30296688

Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain., PMID:30208620

[18F]DPA-714 PET Imaging Reveals Global Neuroinflammation in Zika Virus-Infected Mice., PMID:28900831

Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model., PMID:28822038

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism., PMID:28559417

Advances in positron emission tomography for the imaging of rheumatoid arthritis., PMID:28181650

Functional gains in energy and cell metabolism after TSPO gene insertion., PMID:28103132

Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET., PMID:27578213

Combined [(18)F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice., PMID:27266706

Investigation of the mechanisms of neuroprotection mediated by Ro5-4864 in brain injury., PMID:27223627

In vivo imaging of microglial activation by positron emission tomography with [(11)C]PBR28 in the 5XFAD model of Alzheimer's disease., PMID:26959396

A bispecific antibody (ScBsAbAgn-2/TSPO) target for Ang-2 and TSPO resulted in therapeutic effects against glioblastomas., PMID:26898800

Combined effect of G3139 and TSPO ligands on Ca(2+)-induced permeability transition in rat brain mitochondria., PMID:26498031

Cigarette smoke effects on TSPO and VDAC expression in a cellular lung cancer model., PMID:26378498

Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice., PMID:25796326

Acute neuroinflammation in a clinically relevant focal cortical ischemic stroke model in rat: longitudinal positron emission tomography and immunofluorescent tracking., PMID:25601153

Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain., PMID:25493280

Carbenoxolone induces permeability transition pore opening in rat mitochondria via the translocator protein TSPO and connexin43., PMID:24995971

Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis., PMID:24625077

A self-internalizing mitochondrial TSPO targeting imaging probe for fluorescence, MRI and EM., PMID:32051760

Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction., PMID:23899557

Document Download

Anti-Human TSPO Antibody (SAA1799).pdf