Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life., PMID:40442822
Pittsburgh plasma p-tau217: classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the community., PMID:40385398
Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier., PMID:39289695
Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer's disease., PMID:39085976
Multiple system atrophy with amyloid-β-predominant Alzheimer's disease neuropathologic change., PMID:38712319
Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments., PMID:38247923
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread., PMID:38086389
A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial., PMID:36373344
Recent Advances in the Modeling of Alzheimer's Disease., PMID:35431779
Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study., PMID:35305339
11C-PiB PET can underestimate brain amyloid-β burden when cotton wool plaques are numerous., PMID:34918018
Unraveling the Gordian knot: genetics and the troubled road to effective therapeutics for Alzheimer's disease., PMID:34718566
A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide., PMID:34329683
Neuroprotective Effects of Asparagus officinalis Stem Extract in Transgenic Mice Overexpressing Amyloid Precursor Protein., PMID:34046506
Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis., PMID:33712740
Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor., PMID:33252082
Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer's Disease., PMID:33252074
Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology., PMID:33225991
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability., PMID:33119191
Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders., PMID:32722745
Baseline demographic, clinical, and cognitive characteristics of the Alzheimer's Prevention Initiative (API) Autosomal-Dominant Alzheimer's Disease Colombia Trial., PMID:32418361
Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs isogenic controls., PMID:31782729
Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis., PMID:30645585
The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort., PMID:29955659
Immunotherapy to improve cognition and reduce pathological species in an Alzheimer's disease mouse model., PMID:29914551
[Effect of intrahippocampal injection of anti-cellular prion protein monoclonal antibody on cognitive deficits in APPswe/PSEN1dE9 transgenic mice]., PMID:29735445
Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice., PMID:29710702
Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques., PMID:29690919
The Value of Pre-Screening in the Alzheimer's Prevention Initiative (API) Autosomal Dominant Alzheimer's Disease Trial., PMID:29405233
Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study., PMID:29397305
Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice., PMID:29386065
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease., PMID:29293211
Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-β burden in several amyloid transgenic mouse models., PMID:29134678
N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models., PMID:28978359
[DIAN/DIAN-J/DIAN-TU]., PMID:28739983
C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease., PMID:28559572
Characterization of an 'Amyloid Only' Transgenic (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax) Mouse Model of Alzheimer's Disease., PMID:28431735
Prophylactic Vaccine Based on Pyroglutamate-3 Amyloid β Generates Strong Antibody Response and Rescues Cognitive Decline in Alzheimer's Disease Model Mice., PMID:28292186
Lack of P-glycoprotein Results in Impairment of Removal of Beta-Amyloid and Increased Intraparenchymal Cerebral Amyloid Angiopathy after Active Immunization in a Transgenic Mouse Model of Alzheimer's Disease., PMID:27915995
TREM1 facilitates microglial phagocytosis of amyloid beta., PMID:27670763
Reduced Efficacy of Anti-Aβ Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity., PMID:27656027
Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer's disease., PMID:27572246
Expression of the Alzheimer's Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs., PMID:27540966
Deposition of BACE-1 Protein in the Brains of APP/PS1 Double Transgenic Mice., PMID:27294139
[Significance and progress of DIAN/A4/API]., PMID:27025079
Characterization of Amyloid-β Deposits in Bovine Brains., PMID:26890772
Effects of an amyloid-beta 1-42 oligomers antibody screened from a phage display library in APP/PS1 transgenic mice., PMID:26820640
Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice., PMID:26254061
Lack of support for bexarotene as a treatment for Alzheimer's disease., PMID:26025659
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease., PMID:25747037
For research use only. Not for human or drug use.
