Catalog No.
RHK84801
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
SARP-1, Secreted frizzled-related protein 2, Secreted apoptosis-related protein 1, sFRP-2, FRP-2, SARP1, FRP2, SFRP2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q96HF1
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1747
SFRP1 and SFRP2 jointly regulate normal and malignant hematopoietic progenitors by influencing mesenchymal cells in the hematopoietic niche., PMID:40446746
SFRP2 mediates Epstein-Barr virus and bladder cancer risk: a Mendelian randomization study and colocalization analysis., PMID:40016549
Overcoming PD-1 Inhibitor Resistance with a Monoclonal Antibody to Secreted Frizzled-Related Protein 2 in Metastatic Osteosarcoma., PMID:34070758
Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders., PMID:33384688
Scl-Ab reverts pro-osteoclastogenic signalling and resorption in estrogen deficient osteocytes., PMID:33148174
Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis., PMID:33140138
sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients., PMID:33097493
Accelerated blood clearance of targeted ultrasound contrast reduced molecular imaging signal intensity: Secreted Frizzled Related Protein-2 signal remained significantly higher than signal from either Vascular Endothelial Growth Factor Receptor-2 or alphaVbeta3 integrin., PMID:34650779
Development of a Novel Humanized Monoclonal Antibody to Secreted Frizzled-Related Protein-2 That Inhibits Triple-Negative Breast Cancer and Angiosarcoma Growth In Vivo., PMID:31515721
Editorial: A Novel Monoclonal Antibody-Targeting Angiogenesis by Inhibiting Secreted Frizzled-Related Protein 2., PMID:31502016
Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options., PMID:30770859
Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling., PMID:29151594
Dampening of the bone formation response following repeat dosing with sclerostin antibody in mice is associated with up-regulation of Wnt antagonists., PMID:29129759
Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma., PMID:28333964
Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2-WNT Signaling Axis., PMID:28108510
Thyroid hormone activates Wnt/β-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis., PMID:27068920
SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment., PMID:26751775
Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling., PMID:26730270
A novel function for Wnt signaling modulating neuronal firing activity and the temporal structure of spontaneous oscillation in the entorhinal-hippocampal circuit., PMID:25857536
Ultrasound molecular imaging of secreted frizzled related protein-2 expression in murine angiosarcoma., PMID:24489757
A new molecular target for blunting organ fibrosis. Focus on "Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention"., PMID:24452379
Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention., PMID:24336656
Neural stem cells inhibit melanin production by activation of Wnt inhibitors., PMID:24016750
A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth., PMID:23604067
Wnt and BMP signaling cooperate with Hox in the control of Six2 expression in limb tendon precursor., PMID:23499659
The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus., PMID:21673995
sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair., PMID:20826809
Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation., PMID:20795789
Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway., PMID:20069066
[The interaction between secreted frizzled-related protein 2 and osteoblast-specific factor 2 in keloid]., PMID:19799038
Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity., PMID:18559517
Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma., PMID:18497987
DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines., PMID:18404682
SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional autofeedback loop of Wnt3a., PMID:17916803
SAGE reveals expression of Wnt signalling pathway members during mouse prostate development., PMID:16378759
Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2., PMID:16030194
Altered expression of secreted frizzled-related protein-2 in retinitis pigmentosa retinas., PMID:10798643
For research use only. Not for human or drug use.
