Catalog No.
RHH25201
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Prostacyclin-stimulating factor, IGFBP7, MAC25, MAC25 protein, IGFBP-rP1, Tumor-derived adhesion factor, TAF, PSF, IGF-binding protein 7, IGFBP-7, IBP-7, PGI2-stimulating factor, Insulin-like growth factor-binding protein 7
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16270
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1683
CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors., PMID:39805660
Immuno-PET Imaging of CD93 Expression with 64Cu-Radiolabeled NOTA-mCD93 ([64Cu]Cu-NOTA-mCD93) and Insulin-Like Growth Factor Binding Protein 7 ([64Cu]Cu-NOTA-IGFBP7)., PMID:39533706
IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways., PMID:39533382
Targeting IGF-IR improves neoadjuvant chemotherapy efficacy in breast cancers with low IGFBP7 expression., PMID:39362991
Activated Clec4nhi Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner., PMID:38574235
IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis., PMID:37298628
[Not Available]., PMID:36623864
Insulin-like growth factor-binding protein-7 (IGFBP7) links senescence to heart failure., PMID:39196168
Canadian Cardiovascular Harmonized National Guideline Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2022 update., PMID:36343954
Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia., PMID:34438446
Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy., PMID:34321321
Association of lipoproteins and thyroid hormones with cognitive dysfunction in patients with systemic lupus erythematosus., PMID:34103098
Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers., PMID:32849633
Secretome Analysis Performed During in vitro Cardiac Differentiation: Discovering the Cardiac Microenvironment., PMID:32117977
IGFBP7 contributes to epithelial-mesenchymal transition of HPAEpiC cells in response to radiation., PMID:30834595
Urinary TIMP-2 Predicts the Presence and Duration of Delayed Graft Function in Donation After Circulatory Death Kidney Transplant Recipients., PMID:30300282
Silence of IGFBP7 suppresses apoptosis and epithelial mesenchymal transformation of high glucose induced-podocytes., PMID:30112052
Secretome analysis of in vitro aged human mesenchymal stem cells reveals IGFBP7 as a putative factor for promoting osteogenesis., PMID:29545581
IGFBP7 Deletion Promotes Hepatocellular Carcinoma., PMID:28619711
36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016., PMID:27885969
Protein Profiling Gastric Cancer and Neighboring Control Tissues Using High-Content Antibody Microarrays., PMID:27600085
Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium., PMID:26407999
Epithelial ovarian cancer-induced angiogenic phenotype of human omental microvascular endothelial cells may occur independently of VEGF signaling., PMID:24466373
High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner., PMID:24427302
Effects of HLEC on the secreted proteins of epithelial ovarian cancer cells prone to metastasize to lymph nodes., PMID:24349832
Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls., PMID:24106111
Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure., PMID:23713052
Vitiligo: a possible model of degenerative diseases., PMID:23555779
Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma., PMID:23321464
Insulin-like growth factor binding protein 7 modulates estrogen-induced trophoblast proliferation and invasion in HTR-8 and JEG-3 cells., PMID:22383111
Evaluation of brain tumor vessels specific contrast agents for glioblastoma imaging., PMID:22013169
IGFBP7, a novel immunohistochemical marker in differentiating dermatofibroma from dermatofibrosarcoma protuberans., PMID:21492256
Small unilamellar vesicles: a platform technology for molecular imaging of brain tumors., PMID:21436507
Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies., PMID:20959824
Insulin like growth factor binding protein-7 reduces growth of human breast cancer cells and xenografted tumors., PMID:20464481
Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling., PMID:20145614
Insulin-like growth factor binding protein-7 induces activation and transdifferentiation of hepatic stellate cells in vitro., PMID:19598300
Circulating IGF-binding protein 7 (IGFBP7) levels are elevated in patients with endometriosis or undergoing diabetic hemodialysis., PMID:19019211
Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling., PMID:18711401
Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins., PMID:17545519
Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature., PMID:16794251
Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells., PMID:16586492
Human prostate cancer expresses the low affinity insulin-like growth factor binding protein IGFBP-rP1., PMID:10383131
Generation and characterization of an IGFBP-7 antibody: identification of 31kD IGFBP-7 in human biological fluids and Hs578T human breast cancer conditioned media., PMID:9100611
For research use only. Not for human or drug use.
