Catalog No.
RHG16501
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
MFGM, HMFG, MFG-E8, MFGE8, SED1, Milk fat globule-EGF factor 8, Breast epithelial antigen BA46, Lactadherin
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q08431
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1663
MFGE8 Acts as a Cell Adhesion Factor for Human-Induced Pluripotent Stem Cells in Embryology., PMID:39869126
MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1., PMID:39842432
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis., PMID:39813006
Glia maturation factor-γ regulates amyloid-β42 phagocytosis through scavenger receptor class A type I in murine macrophages., PMID:39243388
Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG-E8., PMID:38332689
PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin., PMID:38199575
Unravelling heterogeneous effects of cancer‑associated fibroblasts on poor prognosis markers in breast cancer EM‑G3 cell line: In vitro‑targeted treatment (anti‑IL-6, anti‑VEGF-A, anti‑MFGE8) based on transcriptomic profiling., PMID:37975220
Targeting MFGE8 secreted by cancer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma., PMID:37816055
Medin co-aggregates with vascular amyloid-β in Alzheimer's disease., PMID:36385530
Preventing SARS-CoV-2 Infection Using Anti-spike Nanobody-IFN-β Conjugated Exosomes., PMID:36163411
Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation., PMID:35126352
Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation., PMID:34953020
CX3CL1(+) Microparticles-Induced MFG-E8 Enhances Apoptotic Cell Clearance by Alveolar Macrophages., PMID:34685562
MFG-E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose-Dependent Mediation of Actin Polymerization., PMID:34041925
Phosphatidylserine-exposing tumor-derived microparticles exacerbate coagulation and cancer cell transendothelial migration in triple-negative breast cancer., PMID:33995667
A novel role for milk fat globule-EGF factor 8 protein (MFGE8) in the mediation of mouse sperm-extracellular vesicle interactions., PMID:33792189
Milk fat globule epidermal growth factor 8 (MFG-E8) on monocytes is a novel biomarker of disease activity in systemic lupus erythematosus., PMID:33115371
Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice., PMID:32900929
Dual role of phosphatidylserine and its receptors in osteoclastogenesis., PMID:32612123
Detection of extracellular vesicles in plasma and urine of prostate cancer patients by flow cytometry and surface plasmon resonance imaging., PMID:32497056
Knockdown of milk-fat globule EGF factor-8 suppresses glioma progression in GL261 glioma cells by repressing microglial M2 polarization., PMID:32324268
Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury., PMID:32238460
Milk Fat Globule-Epidermal Growth Factor VIII Ameliorates Brain Injury in the Subacute Phase of Cerebral Ischemia in an Animal Model., PMID:32120456
Milk Fat Globule-EGF Factor 8 Contributes to Progression of Hepatocellular Carcinoma., PMID:32050643
Polymorphisms of MFGE8 are associated with susceptibility and clinical manifestations through gene expression modulation in Koreans with systemic lupus erythematosus., PMID:31811237
Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein., PMID:31615282
Acidification effects on isolation of extracellular vesicles from bovine milk., PMID:31525238
The significance of tumor cells-derived MFG-E8 in tumor growth of angiosarcoma., PMID:31447183
Efficient method for isolation of exosomes from raw bovine milk., PMID:30366501
B cell responses to apoptotic cells in MFG-E8-/- mice., PMID:30286201
MFG-E8/integrin β3 signaling contributes to airway inflammation response and airway remodeling in an ovalbumin-induced murine model of asthma., PMID:30076648
Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach., PMID:29334397
Human predecidual stromal cells have distinctive characteristics of pericytes: Cell contractility, chemotactic activity, and expression of pericyte markers and angiogenic factors., PMID:29277270
Microglial dysfunction as a key pathological change in adrenomyeloneuropathy., PMID:29059709
Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy., PMID:28375666
Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice., PMID:27956229
MFG-E8 Selectively Inhibited Aβ-Induced Microglial M1 Polarization via NF-κB and PI3K-Akt Pathways., PMID:27844286
Milk fat globule-EGF factor 8 suppresses the aberrant immune response of systemic lupus erythematosus-derived neutrophils and associated tissue damage., PMID:27768123
Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice., PMID:27534552
Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase., PMID:27267660
α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism., PMID:27092791
Production of natural IgM antibodies against oxidatively-modified proteins in milk fat globule epidermal growth factor 8 (MFG-E8) deficient mice., PMID:26461321
MFG-E8 inhibits neutrophil migration through αvβ₃-integrin-dependent MAP kinase activation., PMID:25936372
Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin β3/nuclear factor erythroid 2-related factor 2/heme oxygenase pathway in subarachnoid hemorrhage rats., PMID:25342030
Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms., PMID:25206960
Erythrocyte-derived microparticles supporting activated protein C-mediated regulation of blood coagulation., PMID:25136857
Tissue transglutaminase on trophoblast cells as a possible target of autoantibodies contributing to pregnancy complications in celiac patients., PMID:25056191
Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis., PMID:25006249
The amelioration of phagocytic ability in microglial cells by curcumin through the inhibition of EMF-induced pro-inflammatory responses., PMID:24645646
Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform., PMID:24505114
For research use only. Not for human or drug use.
