Anti-Human SYK Antibody (SAA1636)

Catalog No.

RHE43001

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Spleen tyrosine kinase, SYK, Tyrosine-protein kinase SYK, p72-Syk

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P43405

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1636

TREM2 Hit Discovery Using TRIC Technology: A Proof-of-Concept High-Throughput Screening Approach., PMID:40501992

CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma., PMID:40436855

Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model., PMID:40405265

KK2845, a PBD dimer-containing antibody-drug conjugate targeting TIM-3-expressing AML., PMID:40404985

The new era of primary immune thrombocytopenia management in adults: A narrative review of current and emerging treatments., PMID:40374446

Revised free light chain reference intervals enhance risk stratification in monoclonal gammopathy of undetermined significance and reduce overdiagnosis., PMID:40295472

Protectin D1, an omega-3-derived lipid mediator, resolves mast cell-driven allergic inflammation via FcεRⅠ signaling., PMID:40253829

SARS-CoV-2 nucleocapsid protein induces a Mincle-dependent macrophage inflammatory response in acute kidney injury., PMID:40244324

A microprotein encoded by LINC00263 promotes breast cancer osteolytic bone metastasis by inducing osteoclastogenesis and inhibiting osteoclast ferroptosis., PMID:40221529

[Update on marginal zone lymphoma classification, diagnosis and treatment in 2024]., PMID:40157832

Ubiquitin-specific protease 13 regulates FcεRI-mediated mast cell activation and allergic inflammation via SYK protein modulation., PMID:40139593

Evaluating Rituximab Failure Rates in Neuromyelitis Optica Spectrum Disorder: A Nationwide Real-World Study From South Korea., PMID:40065454

CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation., PMID:39990418

Nauclofficines A and B, two novel monoterpenoid indole alkaloids from the Li folk herb Nauclea officinalis with anti-allergic inflammatory effects on RBL-2H3 cells., PMID:39987995

Comparative efficacy of immunotherapy-based treatment versus chemotherapy-only in patients with unresectable NSCLC with disease progression post chemoradiation and durvalumab., PMID:39987799

Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism., PMID:39891235

From phenotypic to molecular diagnosis: Insights from a clinical immunology service focused on inborn errors of immunity in Colombia., PMID:39836844

Perfluorooctane sulfonate attenuates IgE/Ag-stimulated mast cell activation and anaphylactic responses via activating SHP-1 pathway., PMID:39827624

PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPα/SYK/FcγR signalings in tumor associated macrophages., PMID:39824849

Increased Phosphorylation of Intracellular Signaling Molecules Indicates Continuous Activation of Human Autoreactive B-Cells., PMID:39821328

Dietary Linolenic Acid Enhances IgE Binding to Bovine α-Lactalbumin/β-Lactoglobulin and Promotes KU812 Basophil Degranulation via Upregulation of the Lyn/Syk Pathway., PMID:39772611

Plasma cell and cancer stem cell crosstalk in glioblastoma., PMID:39753137

Intravenous immunoglobulin ameliorates doxorubicin-induced intestinal mucositis by inhibiting the Syk/PI3K/Akt axis and ferroptosis., PMID:39720979

Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody-induced immunothrombosis., PMID:39705541

The significance of free light-chain ratio in light-chain monoclonal gammopathy of undetermined significance: a flow cytometry sub-study of the iStopMM screening study., PMID:39695077

Targeting spleen tyrosine kinase (SYK): structure, mechanisms and drug discovery., PMID:39653169

Antimicrobial Peptide Pro10-1D Exhibits Anti-Allergic Activity: A Promising Therapeutic Candidate., PMID:39596204

JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL., PMID:39570282

Regulation of BCR-dependent germinal center B-cell formation by HGAL and insight into its emerging myeloid ortholog, C1ORF150., PMID:39474423

BCR ligation selectively inhibits IgE class switch recombination., PMID:39345367

BTN2A1 targeting reprograms M2-like macrophages and TAMs via SYK and MAPK signaling., PMID:39325623

Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infection., PMID:39324816

Egfl6 promotes ovarian cancer progression by enhancing the immunosuppressive functions of tumor-associated myeloid cells., PMID:39312740

A novel role for thioredoxin-related transmembrane protein TMX4 in platelet activation and thrombus formation., PMID:39307246

Genetic regulation of B cell receptor signaling pathway: Insights from expression quantitative trait locus analysis using a mixed model., PMID:39236423

Syk inhibitors reduce tau protein phosphorylation and oligomerization., PMID:39233131

CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells., PMID:39187291

CpG oligonucleotides induce acute murine thrombocytopenia dependent on toll-like receptor 9 and spleen tyrosine kinase pathways., PMID:39155024

Tyrosine Protein Kinase SYK-Related Gene Signature in Baseline Immune Cells Associated with Adjuvant Immunotherapy-Induced Immune-Related Adverse Events in Melanoma., PMID:39115425

[Screening and validation of therapeutic targets for chronic sinusitis with nasal polyps based on proteomics]., PMID:39107122

Molecularly guided therapy versus chemotherapy after disease control in unfavourable cancer of unknown primary (CUPISCO): an open-label, randomised, phase 2 study., PMID:39096924

Novel treatments for immune thrombocytopenia: targeting platelet autoantibodies., PMID:39072415

The Evolving Role of Bruton's Tyrosine Kinase Inhibitors in B Cell Lymphomas., PMID:39062757

An exploratory study of the damage markers NfL, GFAP, and t-Tau, in cerebrospinal fluid and other findings from a patient cohort enriched for suspected autoimmune psychiatric disease., PMID:39048548

Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response., PMID:39038910

Identification of high-performing antibodies for tyrosine-protein kinase SYK for use in Western Blot, immunoprecipitation and immunofluorescence., PMID:38948505

GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation., PMID:38907048

First-in-class inhibitor of HSP110 blocks BCR activation through SYK phosphorylation in diffuse large B-cell lymphoma., PMID:38906964

Agalactosyl IgG induces liver fibrogenesis via Fc gamma receptor 3a on human hepatic stellate cells., PMID:38886892

Anti-PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation., PMID:38865481

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