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Anti-Human ABCC1 Antibody (SAA1629)

Catalog #:   RHE03201 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG2a, kappa
Applications: ELISA
Accession: P33527
Overview

Catalog No.

RHE03201

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Leukotriene C(4) transporter, ABCC1, MRP, Multidrug resistance-associated protein 1, MRP1, Glutathione-S-conjugate-translocating ATPase ABCC1, LTC4 transporter, ATP-binding cassette sub-family C member 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P33527

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1629

Data Image
References

Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transporters., PMID:40501953

In vitro models to evaluate multidrug resistance in cancer cells: Biochemical and morphological techniques and pharmacological strategies., PMID:39363148

FXR, MRP-1 and SLC7A5: New Targets for the Treatment of Hepatocellular Carcinoma., PMID:39194338

Possible New Histological Prognostic Index for Large B-Cell Lymphoma., PMID:37834968

Recent Advances in Photothermal Therapies Against Cancer and the Role of Membrane Transporter Modulators on the Efficacy of This Approach., PMID:37138532

Anti-proliferative effect of melatonin in human hepatoma HepG2 cells occurs mainly through cell cycle arrest and inflammation inhibition., PMID:36928762

Anti-drug resistance, anti-inflammation, and anti-proliferation activities mediated by melatonin in doxorubicin-resistant hepatocellular carcinoma: in vitro investigations., PMID:36651944

Bilirubin level is decreased in patients with allergic rhinitis., PMID:36470582

Combinatory therapy of MRP1-targeted photoimmunotherapy and liposomal doxorubicin promotes the antitumor effect for chemoresistant small cell lung cancer., PMID:35931394

LncRNA SNHG11 enhances bevacizumab resistance in colorectal cancer by mediating miR-1207-5p/ABCC1 axis., PMID:35324517

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo., PMID:34386326

PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies., PMID:33879555

MDR1 protein (ABC-C1) Over Expression in Giardia Intestinalis Incubated with Albendazole and Nitazoxanide., PMID:33840056

Combination efficacy of pertuzumab and trastuzumab for trastuzumab emtansine-resistant cells exhibiting attenuated lysosomal trafficking or efflux pumps upregulation., PMID:32997196

FcRn Overexpression Expands Diversity of the Humoral Immune Response in bFcRn Transgenic Mice., PMID:32973781

In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta., PMID:32915249

The Effect of Nanosystems on ATP-Binding Cassette Transporters: Understanding the Influence of Nanosystems on Multidrug Resistance Protein-1 and P-glycoprotein., PMID:32290047

Label-free quantitative identification of abnormally ubiquitinated proteins as useful biomarkers for human lung squamous cell carcinomas., PMID:32140187

Cell proliferation and invasion are regulated differently by EGFR and MRP1 in T-DM1-resistant breast cancer cells., PMID:31704984

Cytosolic delivery of inhibitory antibodies with cationic lipids., PMID:31611380

Beta1 integrin blockade overcomes doxorubicin resistance in human T-cell acute lymphoblastic leukemia., PMID:31043590

Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells., PMID:30315846

Efflux Pump Substrates Shuttled to Cytosolic or Vesicular Compartments Exhibit Different Permeability in a Quantitative Human Blood-Brain Barrier Model., PMID:30212633

A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients., PMID:29194580

Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development., PMID:28912477

MRP1 protein expression in leukemic stem cells as a negative prognostic marker in acute myeloid leukemia patients., PMID:28805931

Disruption of the association between drug transporter and actin cytoskeleton abolishes drug resistance in hypertrophic scar., PMID:27926506

Sequences in Linker-1 domain of the multidrug resistance associated protein (MRP1 or ABCC1) bind to tubulin and their binding is modulated by phosphorylation., PMID:27908733

Up-regulation of glutathione-related genes, enzyme activities and transport proteins in human cervical cancer cells treated with doxorubicin., PMID:27424321

Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23., PMID:27297967

Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can Overcome Drug Resistance in Osteosarcoma., PMID:26548759

Cetuximab enhanced the efficacy of chemotherapeutic agent in ABCB1/P-glycoprotein-overexpressing cancer cells., PMID:26506420

Selection of resistant acute myeloid leukemia SKM-1 and MOLM-13 cells by vincristine-, mitoxantrone- and lenalidomide-induced upregulation of P-glycoprotein activity and downregulation of CD33 cell surface exposure., PMID:26002042

Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma., PMID:25823784

Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments., PMID:25646013

RNAi-based knockdown of multidrug resistance-associated protein 1 is sufficient to reverse multidrug resistance of human lung cells., PMID:25605145

Exploration of interactions between membrane proteins embedded in supported lipid bilayers and their antibodies by reflectometric interference spectroscopy-based sensing., PMID:25270526

Immunolocalization of ABC drug transporters in human placenta from normal and gestational diabetic pregnancies., PMID:25029804

Resistance and intolerance to statins., PMID:24996502

Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1., PMID:24937702

WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells., PMID:24903205

Correlation of Nrf2, NQO1, MRP1, cmyc and p53 in colorectal cancer and their relationships to clinicopathologic features and survival., PMID:24695690

Modulation of ABCC1 and ABCG2 proteins by ouabain in human breast cancer cells., PMID:24596392

Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter., PMID:24231430

Parguerenes: Marine red alga bromoditerpenes as inhibitors of P-glycoprotein (ABCB1) in multidrug resistant human cancer cells., PMID:23415901

BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo., PMID:23046348

Inhibition of the MRP1-mediated transport of the menadione-glutathione conjugate (thiodione) in HeLa cells as studied by SECM., PMID:22679290

Induction of DNA strand breaks is critical to predict the cytotoxicity of gemtuzumab ozogamicin against leukemic cells., PMID:22632031

CD40 stimulation induces vincristine resistance via AKT activation and MRP1 expression in a human multiple myeloma cell line., PMID:22445357

Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway., PMID:22354538

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1640

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Anti-Human ABCC1 Antibody (SAA1629) [RHE03201]
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