Anti-Human IGFBP3 Antibody (SAA1589)

Catalog No.

RHD27201

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

IBP-3, Insulin-like growth factor-binding protein 3, IGF-binding protein 3, IBP3, IGFBP-3, IGFBP3

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P17936

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1589

Pharmacodynamics, pharmacokinetics, and toxicology of Fc-growth hormone fusion protein in macaques., PMID:40120208

Antibodies against the receptor for insulin-like growth factor 1 (IGF-1RAb), insulin-like growth factor 1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP-3) in the serum of patients with Graves' and Basedow's disease with and without orbitopathy., PMID:40071798

Cytokine profile of cerebrospinal fluid in pediatric patients with metastatic medulloblastoma., PMID:39524698

Characterization model of the post COVID-19 condition based on immunological, biochemical, and cytokine markers., PMID:39318534

IGF-2-mediated hypoglycemia: a case series and review of the medical therapies for refractory hypoglycemia., PMID:38432069

IGFBP3 induces PD-L1 expression to promote glioblastoma immune evasion., PMID:38326861

Differential effect of cancer-associated fibroblast-derived extracellular vesicles on cisplatin resistance in oral squamous cell carcinoma via miR-876-3p., PMID:38169528

IGF2BP3/HIF1A/YAP signaling plays a role in driving acute-on-chronic liver failure through activating hepatocyte reprogramming., PMID:37257765

Effects of leptin on the viability of human ovarian cancer cells and changes in cytokine expression levels., PMID:37155466

IGFBP-3 promotes cachexia-associated lipid loss by suppressing insulin-like growth factor/insulin signaling., PMID:37014770

Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis., PMID:36602546

Opposing Roles of IGFBP-3 and Heparanase in Regulating A549 Lung Cancer Cell Survival., PMID:36428962

Prognostic value of comprehensive typing based on m6A and gene cluster in TNBC., PMID:36109402

Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt/β-catenin signaling pathway in mice., PMID:35659360

Silica Induction of Diverse Inflammatory Proteome in Lungs of Lupus-Prone Mice Quelled by Dietary Docosahexaenoic Acid Supplementation., PMID:35126352

GH Responsiveness in Children With Noonan Syndrome Compared to Turner Syndrome., PMID:34858328

Gegen Qinlian Decoction ameliorates type 2 diabetes osteoporosis via IGFBP3/MAPK/NFATc1 signaling pathway based on cytokine antibody array., PMID:34798519

Atrial fibrillation: the role of hypoxia-inducible factor-1-regulated cytokines., PMID:33575876

Switching from originator recombinant growth hormone (Genotropin™) to biosimilar (CRISCY™): Results from a 6-month, multicentric, non-inferiority, extension trial., PMID:33260063

IGFBP-3 stimulates human osteosarcoma cell migration by upregulating VCAM-1 expression., PMID:33188835

Antibody microarray analysis of amniotic fluid proteins associated with subsequent ruptured membranes in women with threatened preterm labor., PMID:33155323

Human amniotic mesenchymal stem cells inhibit hepatocellular carcinoma in tumour-bearing mice., PMID:32798252

Identification and validation of differential plasma proteins levels in epithelial ovarian cancer., PMID:32634479

Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells., PMID:32597148

Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3., PMID:32383868

Serum Proteins as New Biomarkers for Whole-Body Exposure to High- and Low-LET Ionizing Radiation., PMID:32273832

Insulin-like growth factor-binding proteins play a significant role in the molecular response to imatinib in chronic myeloid leukemia patients., PMID:32104232

Effects of colostrum instead of formula feeding for the first 2 days postnatum on whole-body energy metabolism and its endocrine control in neonatal calves., PMID:32089303

Multiple Growth Factor Targeting by Engineered Insulin-like Growth Factor Binding Protein-3 Augments EGF Receptor Tyrosine Kinase Inhibitor Efficacy., PMID:32066763

High-performance detection of an abdominal aortic aneurysm biomarker by immunosensing., PMID:31876964

Maternal H. pylori seropositivity is associated with gestational hypertension but is irrelevant to fetal growth and development in early childhood., PMID:31842819

Model-Informed Dose Selection for Xentuzumab, a Dual Insulin-Like Growth Factor-I/II-Neutralizing Antibody., PMID:31562819

Cullin7 enhances resistance to trastuzumab therapy in Her2 positive breast cancer via degrading IRS-1 and downregulating IGFBP-3 to activate the PI3K/AKT pathway., PMID:31461670

Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system., PMID:31326446

Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model., PMID:31322247

Hormone replacement therapy in children with growth hormone deficiency: impact on immune profile., PMID:31215254

The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis., PMID:31159802

Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Umbilical Cord-Derived Mesenchymal Stem Cells., PMID:31023003

Markers of Systemic Inflammation and Environmental Enteric Dysfunction Are Not Reduced by Zinc or Multivitamins in Tanzanian Infants: A Randomized, Placebo-Controlled Trial., PMID:30952509

Transcriptomics and Immunological Analyses Reveal a Pro-Angiogenic and Anti-Inflammatory Phenotype for Decidual Endothelial Cells., PMID:30935090

Comparison in transcriptome and cytokine profiles of mesenchymal stem cells from human umbilical cord and cord blood., PMID:30769140

Contrasting effects of IGF binding protein-3 expression in mammary tumor cells and the tumor microenvironment., PMID:30419192

Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44., PMID:30184438

Modulation of Circulating Protein Biomarkers in Cancer Patients Receiving Bevacizumab and the Anti-Endoglin Antibody, TRC105., PMID:29997150

Randomized phase II trial of cixutumumab alone or with cetuximab for refractory recurrent/metastatic head and neck squamous cell carcinoma., PMID:29909907

Markers of Environmental Enteric Dysfunction Are Associated With Neurodevelopmental Outcomes in Tanzanian Children., PMID:29613921

Peptidyl-prolyl cis/trans isomerase Pin1 regulates withaferin A-mediated cell cycle arrest in human breast cancer cells., PMID:29603395

ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model., PMID:29482621

Insulin-like growth factor-1 (IGF1) in systemic lupus erythematosus: relation to disease activity, organ damage and immunological findings., PMID:29385899

Somapacitan, a once-weekly reversible albumin-binding GH derivative, in children with GH deficiency: A randomized dose-escalation trial., PMID:28656605

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