Catalog No.
RHB12802
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
Low-density lipoprotein receptor-related protein 5, LRP5, LRP-5, LRP7, LRP-7, Low-density lipoprotein receptor-related protein 7, LR3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O75197
Applications
ELISA
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA1526
Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis Imperfecta., PMID:40501669
WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency., PMID:40492997
A multi-faceted discovery strategy identifies functional antibodies binding to cysteine-rich domain 1 of hDKK1 for cancer immunotherapy via Wnt non-canonical pathway., PMID:40394415
Inhibition of Canonical Wnt Signaling in Renal Cell Carcinoma Bone Metastasis: An Immunohistochemical Analysis of DKK1 and LRP5 Expression., PMID:40337977
SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance., PMID:40173040
Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364
Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation., PMID:39824186
Incident Vertebral Fractures During Romosozumab Treatment in a Patient With a Pathogenic LRP5 Variant., PMID:39726666
Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-retina barrier integrity., PMID:39693351
A mechanism of action-reflective, dual cell-based bioassay for determining the bioactivity of sclerostin-neutralizing antibodies., PMID:39389544
Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression., PMID:39010070
Progress in the development of modulators targeting Frizzleds., PMID:38936522
Inhibition of a novel Dickkopf-1-LDL receptor-related proteins 5 and 6 axis prevents diabetic cardiomyopathy in mice., PMID:38152853
Vitiligo progression in a patient undergoing romosozumab treatment for osteoporosis., PMID:37965188
A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response., PMID:37559903
The Effect of Sclerostin and Monoclonal Sclerostin Antibody Romosozumab on Osteogenesis and Osteoclastogenesis Mediated by Periodontal Ligament Fibroblasts., PMID:37108735
Sostdc1 Suppression in the Absence of Sclerostin Potentiates Anabolic Action of Cortical Bone in Mice., PMID:36891756
Netrin-1 binding to Unc5B regulates Blood-Retina Barrier integrity., PMID:36711611
Targeting Sclerostin and Dkk1 at Optimized Proportions of Low-Dose Antibody Achieves Similar Skeletal Benefits to Higher-Dose Sclerostin Targeting in the Mature Adult and Aged Skeleton., PMID:36465166
Drug discovery of sclerostin inhibitors., PMID:35646527
WNT5A Interacts With FZD5 and LRP5 to Regulate Proliferation and Self-Renewal of Endometrial Mesenchymal Stem-Like Cells., PMID:35295855
Suppression of Sost/Sclerostin and Dickkopf-1 Augment Intervertebral Disc Structure in Mice., PMID:35278242
Sclerostin Inhibition: A Novel Target for the Treatment of Postmenopausal Osteoporosis., PMID:35264832
IgD promotes pannus formation by activating Wnt5A-Fzd5-CTHRC1-NF-κB signaling pathway in FLS of CIA rats and the regulation of IgD-Fc-Ig fusion protein., PMID:34688134
The Wnt/β-catenin signaling pathway has a healing ability for periapical periodontitis., PMID:34608236
LRPs in WNT Signalling., PMID:34490514
ENO1 Promotes Lung Cancer Metastasis via HGFR and WNT Signaling-Driven Epithelial-to-Mesenchymal Transition., PMID:34145039
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy., PMID:34105895
The nanoscale organization of the Wnt signaling integrator Dishevelled in the vegetal cortex domain of an egg and early embryo., PMID:34038442
Ehrlichia chaffeensis TRP120 Is a Wnt Ligand Mimetic That Interacts with Wnt Receptors and Contains a Novel Repetitive Short Linear Motif That Activates Wnt Signaling., PMID:33883266
Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling., PMID:33579703
Sclerostin: from bench to bedside., PMID:33206222
Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration., PMID:33164872
Therapeutic normal IgG intravenous immunoglobulin activates Wnt-β-catenin pathway in dendritic cells., PMID:32132640
Assessment of romosozumab efficacy in the treatment of postmenopausal osteoporosis: Results from a mechanistic PK-PD mechanostat model of bone remodeling., PMID:31935526
EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure., PMID:31707150
Combination therapy in the Col1a2G610C mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFβ signaling on trabecular bone but not on cortical bone., PMID:31648079
Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice., PMID:31452509
Myometrial Cells Stimulate Self-Renewal of Endometrial Mesenchymal Stem-Like Cells Through WNT5A/β-Catenin Signaling., PMID:31414525
[The bone and Wnt signaling : overview.]., PMID:30814371
Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells., PMID:30664649
Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature., PMID:30354230
Pigment epithelium derived factor regulates human Sost/Sclerostin and other osteocyte gene expression via the receptor and induction of Erk/GSK-3beta/beta-catenin signaling., PMID:30076958
Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition., PMID:29875318
FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2., PMID:29718273
JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling., PMID:29584620
Effects of pharmacologic sclerostin inhibition or testosterone administration on soleus muscle atrophy in rodents after spinal cord injury., PMID:29579075
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation., PMID:29431745
WNT-mediated Modulation of Bone Metabolism: Implications for WNT Targeting to Treat Extraskeletal Disorders., PMID:29105581
Molecular genetics and targeted therapy of WNT-related human diseases (Review)., PMID:28731148
For research use only. Not for human or drug use.
