Anti-Human ROBO1 Antibody (SAA1494)

Catalog No.

RHK45001

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

H-Robo-1, DUTT1, Roundabout homolog 1, Deleted in U twenty twenty, ROBO1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9Y6N7

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAA1494

Oculomotor axons use external and autocrine Slit signals for fasciculation, navigation, branching, and connectivity in mouse embryos., PMID:40470230

Expression Profiles of Five Common Cancer Membrane Protein Antigens Collected for the Development of Cocktail CAR-T Cell Therapies Applicable to Most Solid Cancer Patients., PMID:40076777

Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells., PMID:39565875

TSHR-IGF-IR complex drives orbital fibroblast misbehavior in thyroid eye disease., PMID:39082947

Cetuximab-Toxin Conjugate and NPe6 with Light Enhanced Cytotoxic Effects in Head and Neck Squamous Cell Carcinoma In Vitro., PMID:38790935

Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy., PMID:38414132

The tyrosine kinase inhibitor nintedanib enhances the efficacy of 90 Y-labeled B5209B radioimmunotherapy targeting ROBO1 without increased toxicity in small-cell lung cancer xenograft mice., PMID:37728607

Novel concept of Wilms' tumor development: involvement of pluripotential cells of ureteric bud., PMID:37209922

Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma., PMID:36792623

Targeting Redundant ROBO1 and SDF-1 Pathways Prevents Adult Hemangioblast Derived-EPC and CEC Activity Effectively Blocking Tumor Neovascularization., PMID:36652143

Pan-Cancer Analysis Identifies Tumor Cell Surface Targets for CAR-T Cell Therapies and Antibody Drug Conjugates., PMID:36428765

Novel antigens for targeted radioimmunotherapy in hepatocellular carcinoma., PMID:35708866

Peptide-Based Vaccines for Hepatocellular Carcinoma: A Review of Recent Advances., PMID:34513746

Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells., PMID:33844018

teiresias, a Fruitless target gene encoding an immunoglobulin-superfamily transmembrane protein, is required for neuronal feminization in Drosophila., PMID:33087851

Slit2 is a potential biomarker for renal impairment in systemic lupus erythematosus., PMID:33079290

Photosensitizer With Illumination Enhances In Vivo Antitumor Effect of Anti-ROBO1 Immunotoxin on Maxillary Sinus Squamous Cell Carcinoma., PMID:32620618

Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma., PMID:32256588

Generation of biparatopic antibody through two-step targeting of fragment antibodies on antigen using SpyTag and SpyCatcher., PMID:31993343

Roundabout1 distribution in neoplastic and non-neoplastic diseases with a focus on neoangiogenesis., PMID:31949661

R5, a neutralizing antibody to Robo1, suppresses breast cancer growth and metastasis by inhibiting angiogenesis via down-regulating filamin A., PMID:31811830

Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review., PMID:31504506

Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface., PMID:30595454

Slit2/Robo4 axis may contribute to endothelial cell dysfunction and angiogenesis disturbance in systemic sclerosis., PMID:30021803

Robo1 Forms a Compact Dimer-of-Dimers Assembly., PMID:29307485

Use of SpyTag/SpyCatcher to construct bispecific antibodies that target two epitopes of a single antigen., PMID:28637250

Slit2‑Robo1 signaling promotes the adhesion, invasion and migration of tongue carcinoma cells via upregulating matrix metalloproteinases 2 and 9, and downregulating E‑cadherin., PMID:27431199

Kinetic exclusion assay of monoclonal antibody affinity to the membrane protein Roundabout 1 displayed on baculovirus., PMID:27095060

Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4., PMID:26713366

Expression of Robo protein in bladder cancer tissues and its effect on the growth of cancer cells by blocking Robo protein., PMID:26617702

Activation of Slit2-Robo1 signaling promotes liver fibrosis., PMID:26264936

90Y-Labeled Anti-ROBO1 Monoclonal Antibody Exhibits Antitumor Activity against Small Cell Lung Cancer Xenografts., PMID:26017283

Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction., PMID:25530182

Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain-antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses., PMID:25492858

A (90)Y-labelled anti-ROBO1 monoclonal antibody exhibits antitumour activity against hepatocellular carcinoma xenografts during ROBO1-targeted radioimmunotherapy., PMID:25006547

Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis., PMID:24840330

ROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: study in African-American and Caucasian prostate cancer models., PMID:24752651

New antiangiogenic strategies beyond inhibition of vascular endothelial growth factor with special focus on axon guidance molecules., PMID:24401553

Genome-wide association study of antibody response to Newcastle disease virus in chicken., PMID:23663563

Cerebral endothelial expression of Robo1 affects brain infiltration of polymorphonuclear neutrophils during mouse stroke recovery., PMID:23473743

Slit/Robo1 signaling regulates neural tube development by balancing neuroepithelial cell proliferation and differentiation., PMID:23438940

[Role of Slit-Robo signaling in the proliferation of human mucoepidermoid carcinoma Mc3 cells]., PMID:22366001

Protein markers and differentiation in culture for Schlemm's canal endothelial cells., PMID:22210126

The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis., PMID:22198087

Effects of Roundabout 5 on adhesion, invasion and potential motility of human tongue carcinoma Tb cells., PMID:21933570

Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation., PMID:20944010

Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis., PMID:20438712

Effect of Robo1 on retinal pigment epithelial cells and experimental proliferative vitreoretinopathy., PMID:20071679

Targeting Slit-Roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis., PMID:18201275

Slit2 involvement in glioma cell migration is mediated by Robo1 receptor., PMID:17968499

Document Download

Anti-Human ROBO1 Antibody (SAA1494).pdf