Anti-Human HTT Antibody (C4)

Catalog No.

RHE38304

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Target

Huntingtin, Huntington disease protein, HD protein, Huntingtin, myristoylated N-terminal fragment, HTT, HD, IT15

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P42858

Applications

ELISA

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

C4

Accurate Quantification of Mutant and Wild-Type polyQ Proteins Using Simple Western Capillary Immunoassays., PMID:40450087

Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington's disease human cerebral cortex., PMID:40319093

Targeted proteomic biomarker profiling using NULISA in a cohort enriched with risk for Alzheimer's disease and related dementias., PMID:40318118

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification., PMID:40259428

Multimer Detection System: A Universal Assay System for Differentiating Protein Oligomers from Monomers., PMID:39940966

Efficacy of bevacizumab in hereditary hemorrhagic telangiectasia: a systematic review and network meta-analysis., PMID:39891697

Detection of HTTex1p by western blot and immunostaining of HD human and mouse brain using neo-epitope antibody P90 highlights impact of CAG repeat expansion on its size, solubility, and response to MSH3 silencing., PMID:39803497

Metastasis of clear cell renal cell carcinoma to hyalinizing trabecular tumor of the thyroid: A case report., PMID:39722749

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays., PMID:39713241

Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 influenza virus with reduced adverse reactions., PMID:39690742

BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate., PMID:39642886

Isatuximab-dexamethasone-pomalidomide combination effects on serum M protein and PFS in myeloma: Development of a joint model using phase I/II data., PMID:39607833

Adaptive immunity in Mus musculus influences the acquisition and abundance of Borrelia burgdorferi in Ixodes scapularis ticks., PMID:39503497

Facilitating and restraining virus infection using cell-attachable soluble viral receptors., PMID:39480852

Comparison of MIB-1-Specific Membrane Staining in Hyalinising Trabecular Tumor Using Mainstream Automated Immunohistochemical Staining Platforms., PMID:39447085

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification., PMID:39386513

Advancements in surgical treatments for Huntington disease: From pallidotomy to experimental therapies., PMID:39304438

A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence., PMID:39257448

Dengue Hemorrhagic Fever in Quang Nam Province (Vietnam) from 2020 to 2022-A Study on Serotypes Distribution and Immunology Factors., PMID:39202259

CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity., PMID:38869076

Evidence of mutant huntingtin and tau-related pathology within neuronal grafts in Huntington's disease cases., PMID:38810948

Transient interdomain interactions modulate the monomeric structural ensemble and self-assembly of Huntingtin Exon 1., PMID:38766024

Synergistic effect of two human-like monoclonal antibodies confers protection against orthopoxvirus infection., PMID:38627363

Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease., PMID:38092268

A Specific Mini-Intrabody Mediates Lysosome Degradation of Mutant Huntingtin., PMID:37688357

Structure-based design of a strain transcending AMA1-RON2L malaria vaccine., PMID:37660103

Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain., PMID:37633260

COVID-19 knowledge deconstruction and retrieval: an intelligent bibliometric solution., PMID:37360228

Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters., PMID:37237062

Model-based simulation to support the approval of isatuximab alone or with dexamethasone for the treatment of relapsed/refractory multiple myeloma in Japanese patients., PMID:37002644

Detection of antibodies against the huntingtin protein in human plasma., PMID:36651994

N-terminal mutant huntingtin deposition correlates with CAG repeat length and symptom onset, but not neuronal loss in Huntington's disease., PMID:36220612

Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis., PMID:35984416

Current and Possible Future Therapeutic Options for Huntington's Disease., PMID:35615642

Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation., PMID:35395060

Exposure-response analyses for selection/confirmation of optimal isatuximab dosing regimen in combination with pomalidomide/dexamethasone treatment in patients with multiple myeloma., PMID:35355430

Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells., PMID:35058188

Joint modelling and simulation of M-protein dynamics and progression-free survival for alternative isatuximab dosing with pomalidomide/dexamethasone., PMID:34705283

Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice., PMID:34625612

Amplification of neurotoxic HTTex1 assemblies in human neurons., PMID:34563643

Estrogen Promotes Resistance to Bevacizumab in Murine Models of NSCLC., PMID:34311109

Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington's Disease Knock-in Mice., PMID:34239412

PK/PD modeling analysis for dosing regimen selection of isatuximab as single agent and in combination therapy in patients with multiple myeloma., PMID:34185964

The engineered expression of secreted HSPB5-Fc in CHO cells exhibits cytoprotection in vitro., PMID:34126963

Involvement of Huntingtin in Development and Ciliary Beating Regulation of Larvae of the Sea Urchin, Hemicentrotus pulcherrimus., PMID:34066037

Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes., PMID:33730050

Effects of GABA/β-glucan supplements on melatonin and serotonin content extracted from natural resources., PMID:33667254

Target-induced clustering activates Trim-Away of pathogens and proteins., PMID:33633400

Inhibition of p38 Mitogen-Activated Protein Kinase Ameliorates HAP40 Depletion-Induced Toxicity and Proteasomal Defect in Huntington's Disease Model., PMID:33492644

Loading Imatinib inside targeted nanoparticles to prevent Bronchiolitis Obliterans Syndrome., PMID:33244143

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