Catalog No.
YMN00401
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Ser55-Leu185
Predicted molecular weight
42.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q76LW6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DAN domain family member 5, Cerberus-like protein 2, Dand5, Cerl-2, Cerl2, Sp1
CACNA1G, A Heterotaxy Candidate Gene, Plays a Role in Ciliogenesis and Left-Right Patterning in Xenopus tropicalis., PMID:40008628
CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans., PMID:39753129
Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer., PMID:38940473
Molecular Pathways and Animal Models of Defects in Situs., PMID:38884745
R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient., PMID:38307837
Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3., PMID:37733651
Depletion of DAND5 Hinders EMT in Mouse Embryonic Stem Cell Differentiation., PMID:37194232
Gene-Edited Human-Induced Pluripotent Stem Cell Lines to Elucidate DAND5 Function throughout Cardiac Differentiation., PMID:36831187
Immotile cilia mechanically sense the direction of fluid flow for left-right determination., PMID:36603091
A novel biallelic loss-of-function variant in DAND5 causes heterotaxy syndrome., PMID:36316122
Reemployment of Kupffer's vesicle cells into axial and paraxial mesoderm via transdifferentiation., PMID:35129208
Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates., PMID:34903892
Evolution of the DAN gene family in vertebrates., PMID:34902310
Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5., PMID:34531379
Whole-exome sequencing reveals a monogenic cause in 56% of individuals with laterality disorders and associated congenital heart defects., PMID:34215651
Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex., PMID:34210974
Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics and Dand5., PMID:33869175
Altering metabolite distribution at Xenopus cleavage stages affects left-right gene expression asymmetries., PMID:33826226
Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway., PMID:33793856
COCO/DAND5 inhibits developmental and pathological ocular angiogenesis., PMID:33587337
Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G > A alteration in DAND5., PMID:31869685
Cilia-driven asymmetric Hedgehog signalling determines the amphioxus left-right axis by controlling Dand5 expression., PMID:31826864
Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure., PMID:30685069
Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse., PMID:30446628
Gene co-expression network analysis identifies the hub genes associated with immune functions for nocturnal hemodialysis in patients with end-stage renal disease., PMID:30212930
Generation and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alteration., PMID:29730570
A Conserved Role of the Unconventional Myosin 1d in Laterality Determination., PMID:29478852
Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration., PMID:29136563
Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer., PMID:28875937
Elevated serum DAND5 is associated with metastasis and predicts poor prognosis in colorectal cancer., PMID:28815037
Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects., PMID:28738792
A Targeted, Next-Generation Genetic Sequencing Study on Tetralogy of Fallot, Combined With Cleft Lip and Palate., PMID:28230599
Leftward Flow Determines Laterality in Conjoined Twins., PMID:28190730
The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer., PMID:26908452
The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry., PMID:26493400
Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFβ and Wnt signaling., PMID:26443633
Coco is a dual activity modulator of TGFβ signaling., PMID:26116664
Organized chaos in Kupffer's vesicle: how a heterogeneous structure achieves consistent left-right patterning., PMID:25454897
Comparative transcriptome analysis between metastatic and non-metastatic gastric cancer reveals potential biomarkers., PMID:25334039
Symmetry breakage in the frog Xenopus: role of Rab11 and the ventral-right blastomere., PMID:24585437
Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development., PMID:24058481
Coco regulates dorsoventral specification of germ layers via inhibition of TGFβ signalling., PMID:24026124
Identification and expression analysis of BMP signaling inhibitors genes of the DAN family in amphioxus., PMID:23872339
BMP/Coco antagonism as a deterministic factor of metastasis dormancy in lung., PMID:23320613
The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites., PMID:22901808
β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos., PMID:22535411
Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning., PMID:20858476
The nodal inhibitor Coco is a critical target of leftward flow in Xenopus., PMID:20381352
Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos., PMID:19906859
Embryogenesis and expression profiles of charon and nodal-pathway genes in sinistral (Paralichthys olivaceus) and dextral (Verasper variegatus) flounders., PMID:17409727
For research use only. Not for human or drug use.
