Catalog No.
YMK06601
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Gln60-Ser307
Predicted molecular weight
29.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P58022
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lysyl oxidase-like protein 2, Loxl2, Lysyl oxidase homolog 2
SMARCB1 orchestrates cellular plasticity and oncogenic pathways in typical and chondroid chordomas., PMID:40481032
Salivary Extracellular Vesicles in Detection of Head and Neck Cancers: A Systematic Review., PMID:40452788
MMA-induced LOXL2+ PSCs promote linear ECM alignment in the aging pancreas leading to pancreatic cancer progression., PMID:40425551
Bone marrow-targeted LOXL2 inhibitor-loaded yolk-shell nanoparticle overcomes extracellular matrix-mediated chemotherapy resistance in acute myeloid leukemia., PMID:40389070
Shenge powder inhibits myocardial fibrosis in rats with post-myocardial infarction heart failure through LOXL2/TGF-β1/IL-11 signaling pathway., PMID:40342293
Procyanidin C1 ameliorates aging-related skin fibrosis through targeting EGFR to inhibit TGFβ/SMAD pathway., PMID:40315640
The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells., PMID:40304808
Gelatin methacryloyl bioinks for bioprinting nasal cartilage: Balancing mechanical integrity and extracellular matrix formation., PMID:40294687
Neurotrophin-3/chitosan inhibits cuproptosis-related genes to enable functional recovery after spinal cord injury., PMID:40268016
Machine learning-based in-silico analysis identifies signatures of lysyl oxidases for prognostic and therapeutic response prediction in cancer., PMID:40186284
An in vitro model to measure the strength and stiffness of the extracellular matrix synthesized de novo by human fibroblasts., PMID:40160211
Artificial intelligence accelerates the identification of nature-derived potent LOXL2 inhibitors., PMID:40148559
Escin Ia ameliorates DSS-induced chronic colitis in mice by inhibiting inflammation and oxidative stress via the LOXL2/MMP-9 pathway., PMID:40090427
Yiqi Juanshen decoction alleviates renal interstitial fibrosis by targeting the LOXL2/PI3K/AKT pathway to suppress EMT and inflammation., PMID:39905060
Hypoxic stress promotes astrocyte infiltration-like growth via HIF-1α/GDNF/LOXL2 axis., PMID:39894231
Lysyl oxidase-like 2 promotes the survival, migration, and ferroptosis of endometrial cancer cells by activating the phosphoinositide 3-kinase/protein kinase B pathway., PMID:39877633
Loss of phosphatase and tensin homolog (PTEN) increases Lysyl oxidase-like 2 (LOXL2) expression enhancing the growth of fallopian tube epithelial cells as three-dimensional spheroids., PMID:39872364
Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition., PMID:39810997
β-Catenin mediated TAM phenotype promotes pancreatic cancer metastasis via the OSM/STAT3/LOXL2 axis., PMID:39740539
Hyperglycemia inhibits AAA expansion: examining the role of lysyl oxidase., PMID:39716889
NUDT21 regulates lysyl oxidase-like 2(LOXL2) to influence ECM protein cross-linking in silica-induced pulmonary fibrosis., PMID:39700768
O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner., PMID:39671515
Prognostic significance of LOXL2 enzyme activity in primary myelofibrosis., PMID:39654165
Copper Dysmetabolism is Connected to Epithelial-Mesenchymal Transition: A Pilot Study in Colorectal Cancer Patients., PMID:39557817
ERO1A levels are a prognostic indicator in EGFR mutated non small cell lung cancer., PMID:39496753
siLOXL2 Inhibits Endothelial Inflammatory Response and EndMT Induced by ox-LDL., PMID:39419008
Pulling the Rug Out from Under: Biomechanical Microenvironment Remodeling for Induction of Hepatic Stellate Cell Quiescence., PMID:39410721
Preventive Effect of 3,3'-dimethoxy-4,4'-dihydroxy-stilbene Triazole on Pulmonary Fibrosis through Inhibition of Inflammation and Down-regulation of TGF-b Signaling Pathway., PMID:39400768
Non-invasive fibrosis markers are useful in predicting the presence of varices in compensated cirrhosis and variceal bleeding in decompensated cirrhosis., PMID:39384666
Serum LOXL2 is Elevated and an Independent Biomarker in Patients with Coronary Artery Disease., PMID:39295855
Effects of Vitamin C on the Gonad Growth, Texture Traits, Collagen Content and Synthesis Related Gene Expression of Sea Urchin (Mesocentrotus nudus)., PMID:39272349
Hypoxia and Foxn1 alter the proteomic signature of dermal fibroblasts to redirect scarless wound healing to scar-forming skin wound healing in Foxn1-/- mice., PMID:39256768
Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2., PMID:39173635
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells., PMID:39149513
LOXL2-induced PEAR1 Ser891 phosphorylation suppresses CD44 degradation and promotes triple-negative breast cancer metastasis., PMID:39145451
A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer., PMID:39043186
Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice., PMID:39028284
MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression., PMID:39011679
LOXL2 inhibition ameliorates pulmonary artery remodeling in pulmonary hypertension., PMID:39010824
Profile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C., PMID:38997072
Tumor-Intrinsic Perinuclear LOXL2: Prognostic Relevance and Relationship with YAP1 Activation Status in Oral Squamous Cell Carcinoma., PMID:38934185
The role of LOXL2 in tumor progression, immune response and cellular senescence: a comprehensive analysis., PMID:38922489
Potential molecular and cellular mechanisms of the effects of cuproptosis-related genes in the cardiomyocytes of patients with diabetic heart failure: a bioinformatics analysis., PMID:38883603
Translational Studies Reveal the Divergent Effects of Simtuzumab Targeting LOXL2 in Idiopathic Pulmonary Fibrosis., PMID:38873180
Deciphering the TCF19/miR-199a-5p/SP1/LOXL2 pathway: Implications for breast cancer metastasis and epithelial-mesenchymal transition., PMID:38851313
Targeting lysyl oxidase like 2 attenuates OVA-induced airway remodeling partly via the AKT signaling pathway., PMID:38824593
Splicing factor hnRNPA1 regulates alternative splicing of LOXL2 to enhance the production of LOXL2Δ13., PMID:38810697
Skeletal Muscle SIRT3 Deficiency Contributes to Pulmonary Vascular Remodeling in Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction., PMID:38804138
Linagliptin Mitigates TGF-β1 Mediated Epithelial-Mesenchymal Transition in Tacrolimus-Induced Renal Interstitial Fibrosis via Smad/ERK/P38 and HIF-1α/LOXL2 Signaling Pathways., PMID:38797693
RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis via LOXL2 Mediated Mechanism., PMID:38746200
For research use only. Not for human or drug use.
